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CYP2E1 triggered GRP78/ATF6/CHOP signalling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma
Arch Biochem Biophys. 2023 Jul 25:109701. doi: 10.1016/j.abb.2023.109701. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. Cytochrome P450 2E1 (CYP2E1) is an enzyme, primarily involved in the metabolism of xenobiotics and procarcinogens. The present study was designed to investigate the potential role of CYP2E1 triggered endoplasmic reticulum stress in the progression of HCC through inhibition of apoptosis. In vitro CYP2E1 promotes HepG2 cell migration, reduced chromatin condensation, enhanced intracellular ROS accumulation and induce cell cycle progressio...
Source: Archives of Biochemistry and Biophysics - July 27, 2023 Category: Biochemistry Authors: Sharmeen Ishteyaque Karan Singh Yadav Smriti Verma Kaveri R Washimkar Madhav Nilakanth Mugale Source Type: research

Effects of Sedi Herba (Sedum sarmentosum) on attenuating cholestasis by the activation of the farnesoid x receptor (FXR)-mediated signaling
This study aimed to clarify the anti-cholestatic efficacy and the mechanism of S. sarmentosum ethyl acetate extract (SDEAE), as well as to screen the potential compounds with FXR activation. SDEAE effectively ameliorated ANIT-induced cholestasis in rats, as evidenced by the ameliorative histopathology of the liver and the significant decrease in biochemical markers (ALT, AST, ALP, GGT, TBIL, DBIL and TBA). The analysis of bile acid profile by LC-MS indicated that SDEAE decreased the toxic bile acid levels (TCA, TMCA and CA). Western blotting indicated that SDEAE activated FXR-associated pathway, thereby upregulating FXR, S...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Zhenxiu Liu Die Liu Mingyun Chen Wei Zong Xiaoran Zhou Fancheng Meng Yunbin Jiang Min Chen Zhihua Liao Guowei Wang Source Type: research

Leptin enhances hepatic fibrosis and inflammation in a mouse model of cholestasis
Am J Pathol. 2021 Dec 8:S0002-9440(21)00523-X. doi: 10.1016/j.ajpath.2021.11.008. Online ahead of print.ABSTRACTLeptin is an adipokine with roles in food intake and energy metabolism through its actions on neurons in the hypothalamus. The role of leptin in obesity and cardiovascular disorders is well documented; however, its influence on liver conditions such as cholestasis is poorly understood. The effects of exogenous leptin and leptin-neutralizing antibody (Leptin-Ab) on biliary hyperplasia, hepatic fibrosis and inflammation in the multidrug resistance protein 2 knockout (Mdr2KO) mouse model of cholestasis were assessed...
Source: Am J Pathol - December 13, 2021 Category: Pathology Authors: Anca D Petrescu Stephanie Grant Elaina Williams Su Yeon An Nikhil Seth Mark Shell Tyson Amundsen Christopher Tan Yusra Nadeem Matthew Tjahja Lancaster Weld Christopher S Chu Julie Venter Gabriel Frampton Matthew McMillin Sharon DeMorrow Source Type: research

Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis
Am J Pathol. 2021 Dec 8:S0002-9440(21)00523-X. doi: 10.1016/j.ajpath.2021.11.008. Online ahead of print.ABSTRACTLeptin is an adipokine with roles in food intake and energy metabolism through its actions on neurons in the hypothalamus. The role of leptin in obesity and cardiovascular disorders is well documented; however, its influence on liver conditions, such as cholestasis, is poorly understood. The effects of exogenous leptin and leptin-neutralizing antibody on biliary hyperplasia, hepatic fibrosis, and inflammation in the multidrug resistance protein 2 knockout (Mdr2KO) mouse model of cholestasis were assessed by quant...
Source: The American Journal of Pathology - December 13, 2021 Category: Pathology Authors: Anca D Petrescu Stephanie Grant Elaina Williams Su Yeon An Nikhil Seth Mark Shell Tyson Amundsen Christopher Tan Yusra Nadeem Matthew Tjahja Lancaster Weld Christopher S Chu Julie Venter Gabriel Frampton Matthew McMillin Sharon DeMorrow Source Type: research

Leptin enhances hepatic fibrosis and inflammation in a mouse model of cholestasis
Am J Pathol. 2021 Dec 8:S0002-9440(21)00523-X. doi: 10.1016/j.ajpath.2021.11.008. Online ahead of print.ABSTRACTLeptin is an adipokine with roles in food intake and energy metabolism through its actions on neurons in the hypothalamus. The role of leptin in obesity and cardiovascular disorders is well documented; however, its influence on liver conditions such as cholestasis is poorly understood. The effects of exogenous leptin and leptin-neutralizing antibody (Leptin-Ab) on biliary hyperplasia, hepatic fibrosis and inflammation in the multidrug resistance protein 2 knockout (Mdr2KO) mouse model of cholestasis were assessed...
Source: The American Journal of Pathology - December 13, 2021 Category: Pathology Authors: Anca D Petrescu Stephanie Grant Elaina Williams Su Yeon An Nikhil Seth Mark Shell Tyson Amundsen Christopher Tan Yusra Nadeem Matthew Tjahja Lancaster Weld Christopher S Chu Julie Venter Gabriel Frampton Matthew McMillin Sharon DeMorrow Source Type: research

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