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Age-related defects in autophagy alter the secretion of paracrine factors from bone marrow mononuclear cells
Aging (Albany NY). 2021 Jun 4;13. doi: 10.18632/aging.203127. Online ahead of print.ABSTRACTBone marrow mononuclear cell therapy improves cardiac repair after myocardial infarction (MI), in-part through signaling to resident cardiac cells, such as fibroblasts, which regulate scar formation. The efficacy of cell therapy declines with age, as aging of both donor and recipient cells decreases repair responses. Autophagy regulates the microenvironment by both extracellular vesicle (EV)-dependent and independent secretion pathways. We hypothesized that age-related autophagy changes in bone marrow cells (BMCs) alter paracrine si...
Source: Aging - June 5, 2021 Category: Biomedical Science Authors: Azadeh Yeganeh Faisal J Alibhai Stephanie W Tobin Fievel Lim Jun Wu Shuhong Li Richard D Weisel Ren-Ke Li Source Type: research

Down-regulation of Xist and Mir-7a-5p improves LPS-induced myocardial injury.
Conclusions: In this study, we established that down-regulation of xist and mir-7a-5p reduces apoptosis in response to LPS. PMID: 33029099 [PubMed - in process]
Source: International Journal of Medical Sciences - October 9, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Rac1 promotes the survival of H9c2 cells during serum deficiency targeting JNK/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways.
Authors: Zhao J, Jie Q, Li G, Li Y, Liu B, Li H, Luo J, Qin X, Li Z, Wei Y Abstract Rac1, known as a "molecular switch", plays a crucial role in plenty of cellular processes. Rac1 aggravates the damage of myocardial cells in the process of myocardial ischemia-reperfusion during myocardial infarction through activating the NADPH oxidase and bringing about the reactive oxygen species(ROS) generation. Myocardial ischemia and hypoxia are the basic pathogenesis of myocardial infarction and the underlying mechanisms are intricate and varied. Moreover, the regulatory effect of Rac1 on myocardial cells in the condition of ...
Source: International Journal of Medical Sciences - July 18, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Research Articles RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
Myocardial infarction (MI) leads to a systemic surge of vascular inflammation in mice and humans, resulting in secondary ischemic complications and high mortality. We show that, in ApoE–/– mice with coronary ligation, increased sympathetic tone up-regulates not only hematopoietic leukocyte production but also plaque endothelial expression of adhesion molecules. To counteract the resulting arterial leukocyte recruitment, we developed nanoparticle-based RNA interference (RNAi) that effectively silences five key adhesion molecules. Simultaneously encapsulating small interfering RNA (siRNA)–targeting intercel...
Source: Science Translational Medicine - June 7, 2016 Category: Biomedical Science Authors: Sager, H. B., Dutta, P., Dahlman, J. E., Hulsmans, M., Courties, G., Sun, Y., Heidt, T., Vinegoni, C., Borodovsky, A., Fitzgerald, K., Wojtkiewicz, G. R., Iwamoto, Y., Tricot, B., Khan, O. F., Kauffman, K. J., Xing, Y., Shaw, T. E., Libby, P., Langer, R., Tags: Research Articles Source Type: research

Hypoxia activates muscle-restricted coiled-coil protein (MURC) expression via transforming growth factor-{beta} in cardiac myocytes
In conclusion, hypoxia in cultured rat neonatal cardiomyocytes increased MURC expression via the induction of TGF-β, SRF and the ERK pathway. These findings suggest that MURC plays a role in hypoxia-induced hypertrophy in cardiomyocytes.
Source: Clinical Science - September 4, 2013 Category: Biomedical Science Authors: K Shyu, W Cheng, B Wang, H Chang Source Type: research