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FGF21 as Modulator of Metabolism in Health and Disease
In conclusion, FGF21 belongs to a promising class of cytokines that are induced in response to stress and that can be used as a drug, drug target, or through a biomarker, depending on the physio-pathological context. All these findings will become clear when FGF21 will be used as a therapeutic molecule, exploiting the beneficial effects of FGF21 for treating metabolic disease or when it will be blocked to ameliorate disease progression and the onset of disease. Author Contributions CT and MS wrote the manuscript. VR contributed to the discussion. Funding This work was supported from the AFM-Telethon (19524), Italian Mi...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

Involvement of lncR-30245 in myocardial infarction-induced cardiac fibrosis through PPAR-γ-mediated CTGF signaling pathway
ConclusionOur study indicates that the lncR-30245/PPAR-γ/CTGF pathway mediates MI-induced cardiac fibrosis and might be a therapeutic target for various cardiac diseases associated with fibrosis.
Source: Canadian Journal of Cardiology - February 16, 2019 Category: Cardiology Source Type: research

Suppression of lncR-30245 alleviates myocardial infarction induced cardiac fibrosis via the PPAR- γ/CTGF pathway
Conclusion Our study indicates that the lncR-30245/PPAR-γ/CTGF pathway mediates MI-induced cardiac fibrosis and might be a therapeutic target for various cardiac diseases associated with fibrosis. Teaser LncR-30245, a conserved lncRNA promotes collagen production and cardiac fibroblast proliferation. Knockdown of lncR-30245 significantly inhibits TGF-β1-induced collagen production and cardiac fibroblast proliferation. Importantly, silencing of lncR-30245 significantly alleviates cardiac fibrosis and improves cardiac function after MI. The PPAR-γ/CTGF signaling pathway is involved in the regulation of cardiac fibrosis by...
Source: Canadian Journal of Cardiology - April 19, 2018 Category: Cardiology Source Type: research