Suppression of lncR-30245 alleviates myocardial infarction induced cardiac fibrosis via the PPAR- γ/CTGF pathway

Conclusion Our study indicates that the lncR-30245/PPAR-γ/CTGF pathway mediates MI-induced cardiac fibrosis and might be a therapeutic target for various cardiac diseases associated with fibrosis. Teaser LncR-30245, a conserved lncRNA promotes collagen production and cardiac fibroblast proliferation. Knockdown of lncR-30245 significantly inhibits TGF-β1-induced collagen production and cardiac fibroblast proliferation. Importantly, silencing of lncR-30245 significantly alleviates cardiac fibrosis and improves cardiac function after MI. The PPAR-γ/CTGF signaling pathway is involved in the regulation of cardiac fibrosis by lncR-30245 in mice. Our study reveals new insight into the role of lncRNA in cardiac fibrosis.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research