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Islr regulates insulin sensitivity by interacting with Psma4 to control insulin receptor alpha levels in obese mice
Int J Biochem Cell Biol. 2023 Apr 26:106420. doi: 10.1016/j.biocel.2023.106420. Online ahead of print.ABSTRACTInsulin resistance is the leading cause of type 2 diabetes (T2D), and dysfunctional insulin receptor signaling is a major manifestation of this insulin resistance. In T2D, the corresponding insulin receptor levels are aberrantly down-regulated, which is one of the major factors underlying obesity-induced insulin resistance in adipose tissue. However, the precise mechanism of insulin receptor impairment in obese individuals remains unclear. In the current study, we established that immunoglobulin superfamily contain...
Source: The International Journal of Biochemistry and Cell Biology - April 28, 2023 Category: Biochemistry Authors: Yuying Zhang Miaomiao Lan Chang Liu Tongtong Wang Chuncheng Liu Sen Wu Qingyong Meng Source Type: research

ox-LDL induces autophagy-mediated apoptosis by suppressing secretagogin-regulated autophagic flux in pancreatic β-cells
In this study, we aim to explore the role of secretagogin (SCGN) in lipotoxicity-induced β-cell injury. Our results indicate that ox-LDL treatment leads to autophagic cell death, as evidenced by decreased cell viability, aggravated cell apoptosis, and the accumulation of the p62 protein in MIN6 cells. LysoTracker Red staining, TEM and mRFP-GFP-LC3 assays demonstrate that autophagic flux is blocked in ox-LDL-treated MIN6 cells. Intriguingly, SCGN is significantly decreased in MIN6 cells under lipotoxic conditions. Additionally, siRNA-guided SCGN knockdown blocks autophagic flux triggered by rapamycin, while SCGN restoratio...
Source: Acta Biochimica et Biophysica Sinica - February 15, 2023 Category: Biochemistry Authors: Ying Lv Sijie Xiao Shuhui Ouyang Zhengliang Peng Li Wu Ziqing Tang Weizheng Zhang Renxian Cao Jing Yang Source Type: research

Treatment of the metabolic syndrome by siRNA targeting apolipoprotein CIII
AbstractApolipoprotein CIII (apoCIII) is increased in obesity-induced insulin resistance and type-2 diabetes. Emerging evidences support the advantages of small interfering RNAs (siRNAs) to target disease-causing genes. The aim of this study was to develop siRNAs for in vivo silencing of apoCIII and investigate if this results in metabolic improvements comparable to what we have seen using antisense oligonucelotides against apoCIII. Twenty-four siRNAs were synthesized and tested in a dual luciferase reporter assay. The eight best were selected, based on knockdown at 20  nM, and of these, two were selected based on IC50 v...
Source: BioFactors - September 1, 2022 Category: Biochemistry Authors: Patricia Recio ‐López, Ismael Valladolid‐Acebes, Philipp Hadwiger, Markus Hossbach, Monika Krampert, Carla Prata, Per‐Olof Berggren, Lisa Juntti‐Berggren Tags: RESEARCH COMMUNICATION Source Type: research

Gasdermin D is involved in switching from apoptosis to pyroptosis in TLR4-mediated renal tubular epithelial cells injury in diabetic kidney disease
CONCLUSIONS: TLR4 could exacerbate tubular injury and fibrosis via GSDMD-mediated canonical pyroptosis pathway in T2DKD. Activation of GSDMD could inhibit apoptosis and activate pyroptosis, which may involve the potential switch mechanism between TLR4-mediated pyroptosis and apoptosis in T2DKD.PMID:35809639 | DOI:10.1016/j.abb.2022.109347
Source: Archives of Biochemistry and Biophysics - July 9, 2022 Category: Biochemistry Authors: Shuguang Yuan Youliang Wang Zheng Li Xiaojun Chen Panai Song Anqun Chen Zhong Qu Si Wen Hong Liu Xuejing Zhu Source Type: research

Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes
This study is the first to describe Nudt19 as regulator of hepatic lipid metabolism and potential mediator of NAFLD and T2D development.PMID:35367353 | DOI:10.1016/j.bbalip.2022.159153
Source: Biochimica et Biophysica Acta - April 3, 2022 Category: Biochemistry Authors: Sarah G örigk D Margriet Ouwens Tanja Kuhn Delsi Altenhofen Christian Binsch Mareike Damen Jenny Minh-An Khuong Katharina Kaiser Birgit Knebel Heike Vogel Annette Sch ürmann Alexandra Chadt Hadi Al-Hasani Source Type: research

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