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Condition: Diabetes Type 2
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Total 421 results found since Jan 2013.
Inhibition of diabetes-induced Drp1 deSUMOylation prevents retinal vascular lesions associated with diabetic retinopathy
Exp Eye Res. 2022 Nov 23:109334. doi: 10.1016/j.exer.2022.109334. Online ahead of print.ABSTRACTRetinal microvascular endothelial cell (RMEC) injury plays an important role in the pathophysiology diabetic retinopathy (DR). The GTPase dynamin-related protein 1 (Drp1), crucial to mitochondrial dynamics, has been implicated in hyperglycaemia-induced microvascular damage. Moreover, Drp1 can be deSUMOylated by the enzyme sentrin/SUMO-specific protease 3 (SENP3). Whether SENP3/deSUMOylated Drp1 can aggravate DR is unclear. Therefore, we designed this experiment to investigate the role of SENP3/desumoylated Drp1 in DR in vitro an...
Source: Experimental Eye Research - November 26, 2022 Category: Opthalmology Authors: Min Chen Qianhui Zhang Shun Wang Feng Zheng Source Type: research
GDF11 promotes wound healing in diabetic mice via stimulating HIF-1 ɑ-VEGF/SDF-1ɑ-mediated endothelial progenitor cell mobilization and neovascularization
Acta Pharmacol Sin. 2022 Nov 8. doi: 10.1038/s41401-022-01013-2. Online ahead of print.ABSTRACTNon-healing diabetic wounds (DW) are a serious clinical problem that remained poorly understood. We recently found that topical application of growth differentiation factor 11 (GDF11) accelerated skin wound healing in both Type 1 DM (T1DM) and genetically engineered Type 2 diabetic db/db (T2DM) mice. In the present study, we elucidated the cellular and molecular mechanisms underlying the action of GDF11 on healing of small skin wound. Single round-shape full-thickness wound of 5-mm diameter with muscle and bone exposed was made o...
Source: Acta Pharmacologica Sinica - November 8, 2022 Category: Drugs & Pharmacology Authors: Ying Zhang Yi-Yuan Zhang Zhen-Wei Pan Qing-Qi Li Li-Hua Sun Xin Li Man-Yu Gong Xue-Wen Yang Yan-Ying Wang Hao-Dong Li Li-Na Xuan Ying-Chun Shao Meng-Meng Li Ming-Yu Zhang Qi Yu Zhange Li Xiao-Fang Zhang Dong-Hua Liu Yan-Meng Zhu Zhong-Yue Tan Yuan-Yuan Zh Source Type: research
ATF3 Regulates Osteogenic Function by Mediating Osteoblast Ferroptosis in Type 2 Diabetic Osteoporosis
CONCLUSION: Osteoblast ferroptosis under HG conditions is induced by ATF3-mediated inhibition of system Xc- activity, and these events contribute to T2DOP pathogenesis.PMID:36340581 | PMC:PMC9629949 | DOI:10.1155/2022/9872243
Source: Disease Markers - November 7, 2022 Category: Laboratory Medicine Authors: Yantao Zhao Yunxia Du Yijie Gao Zhijie Xu Dexiang Zhao Maowei Yang Source Type: research
Blockage of MyD88 in cardiomyocytes alleviates cardiac inflammation and cardiomyopathy in experimental diabetic mice
In this study, we first found that MyD88 expression was increased in cardiomyocytes of diabetic mouse hearts. In cultured cardiomyocytes, MyD88 inhibition either by siRNA or by small-molecular inhibitor LM8 markedly blocked TLR4-MyD88 complex formation, reduced pro-inflammatory mitogen-activated protein kinases/nuclear factor-κB (MAPKs/NF-κB) cascade activation and decreased pro-inflammatory cytokine expression under high glucose condition. Moreover, pharmacologic inhibition of MyD88 by LM8 showed significantly anti-inflammatory, anti-hypertrophic and anti-fibrotic effects in the hearts of both type 1 and type 2 diabetic...
Source: Biochemical Pharmacology - October 14, 2022 Category: Drugs & Pharmacology Authors: Wu Luo Gaojun Wu Xiaojun Chen Qiuyan Zhang Chunpeng Zou Jun Wang Jun Liu Nipon Chattipakorn Yi Wang Guang Liang Source Type: research
