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Condition: Diabetes Type 1
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Total 127 results found since Jan 2013.
Repurposed major urinary protein pheromones and adult sensory neurons: Roles in neuron plasticity and experimental diabetes
Am J Physiol Endocrinol Metab. 2022 May 30. doi: 10.1152/ajpendo.00001.2022. Online ahead of print.ABSTRACTMajor urinary proteins (MUPs), members of the broader lipocalin protein family, are classified as pheromones that are excreted in male rodent urine to define conspecific territoriality. In screening for differentially regulated mRNA transcripts in a mouse model of type 1 experimental diabetes mellitus (DM), we identified an unexpected upregulation of several closely related MUP transcripts within diabetic sensory dorsal root ganglia (DRGs). Both sexes expressed overall MUP protein content as identified by an antibody ...
Source: Am J Physiol Endocri... - May 31, 2022 Category: Endocrinology Authors: Trevor Poitras Vandana Singh Ramanaguru Piragasam Xiuling Wang Atef Mahmoud Mannaa Ambika Chandrasekhar Jose Martinez Richard Fahlman Douglas W Zochodne Source Type: research
Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice
Oxidative stress is a major cause of diabetic nephropathy. Upregulation of the key antioxidative transcription factor, nuclear factor-erythroid 2-related factor 2 (Nrf2), was found to prevent the development of diabetic nephropathy. The present study was designed to explore the therapeutic effect of Nrf2 induced by proteasomal inhibitor MG132 at a low dose (10 μg/kg) on diabetic nephropathy. Transgenic type 1 diabetic (OVE26) mice displayed renal dysfunction with albuminuria by 3 mo of age, at which time MG132 treatment was started. After 3-mo treatment with MG132, renal function, morphology, and biochemical changes wer...
Source: AJP: Endocrinology and Metabolism - January 1, 2013 Category: Endocrinology Authors: Cui, W., Li, B., Bai, Y., Miao, X., Chen, Q., Sun, W., Tan, Y., Luo, P., Zhang, C., Zheng, S., Epstein, P. N., Miao, L., Cai, L. Tags: Articles Source Type: research
Galectin-3 Deficiency Accelerates High-Fat Diet Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic Islets.
Abstract
Obesity-induced diabetes is associated with low-grade inflammation in adipose tissue and macrophage infiltration of islets. We show that ablation of Galectin-3, a galactoside-binding lectin, accelerates high-fat diet-induced obesity and diabetes. Obese LGALS3(-/-) mice have increased body weight, amount of total visceral adipose tissue, fasting blood glucose and insulin levels, HOMA-IR and markers of systemic inflammation compared to diet-matched WT animals. Obese LGALS3(-/-) visceral adipose tissue exhibited increased incidence of Type-1 T and NKT lymphocytes and pro-inflammatory CD11c+CD11b macrophages ...
Source: Diabetes - January 24, 2013 Category: Endocrinology Authors: Pejnovic N, Pantic J, Jovanovic I, Radosavljevic G, Milovanovic M, Nikolic I, Zdravkovic N, Djukic A, Arsenijevic N, Lukic M Tags: Diabetes Source Type: research
Elevated transcriptional co-activator p102 mediates angiotensin II type 1 receptor up-regulation and extracellular matrix overproduction in the high glucose-treated rat glomerular mesangial cells and isolated glomeruli.
Abstract
P102 is a multifunctional transcriptional co-activator. This experiment is designed to investigate the role of p102 in the activation of renin-angiotensin system (RAS) and sequentially extracellular matrix (ECM) over synthesis in diabetic nephropathy. Rat glomerular mesangial cells (MCs) or isolated glomeruli were cultured in normal glucose (NG, 5.5mM) or high glucose (HG, 25mM) DMEM. The generation of reactive oxygen species was measured by 2',7'-Dichlorodihydrofluorescein diacetate (DCFH-DA) fluorescent probe assay. The protein levels were analyzed by Western blot and the mRNA levels were evaluated by r...
Source: European Journal of Pharmacology - January 30, 2013 Category: Drugs & Pharmacology Authors: Wang Z, Ni J, Shao D, Liu J, Shen Y, Zhou L, Huang Y, Yu C, Wang J, Xue H, Lu L Tags: Eur J Pharmacol Source Type: research
Quercetin and Allopurinol Reduce Liver Thioredoxin‐Interacting Protein to Improve Inflammation and Lipid Accumulation in Diabetic Rats
Conclusions and ImplicationsThese results demonstrate that hepatic TXNIP inhibition by quercetin and allopurinol contributes to the improvement of liver inflammation and lipid accumulation under hyperglycemia condition. Therefore, quercetin and allopurinol targeting hepatic TXNIP may have therapeutic application to prevent type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - May 3, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research
Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats
Conclusions and ImplicationsInhibition of hepatic TXNIP by quercetin and allopurinol contributes to the reduction in liver inflammation and lipid accumulation under hyperglycaemic conditions. The targeting of hepatic TXNIP by quercetin and allopurinol may have therapeutic implications for prevention of type 1 diabetes‐associated NAFLD.
Source: British Journal of Pharmacology - June 21, 2013 Category: Drugs & Pharmacology Authors: Wei Wang, Chuang Wang, Xiao‐Qin Ding, Ying Pan, Ting‐Ting Gu, Ming‐Xing Wang, Yang‐Liu Liu, Fu‐Meng Wang, Shui‐Juan Wang, Ling‐Dong Kong Tags: Research Paper Source Type: research
Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line.
Abstract
Recently, a novel type 1 diabetes association locus was identified at human chromosome 6p31.3, and TCF19 is a likely causal gene. Little is known about Tcf19, and we now show that it plays a role in both proliferation and apoptosis in insulinoma cells. Tcf19 is expressed in mouse and human islets, with increasing mRNA expression in non-diabetic obesity. The expression of Tcf19 is correlated with β-cell mass expansion, suggesting that it may be a transcriptional regulator of β-cell mass. Increasing proliferation and decreasing apoptotic cell death are two strategies to increase pancreatic β-cell mass an...
Source: American Journal of Physiology. Endocrinology and Metabolism - July 16, 2013 Category: Physiology Authors: Krautkramer KA, Linnemann AK, Fontaine DA, Whillock AL, Harris TW, Schleis GJ, Truchan NA, Marty-Santos L, Lavine JA, Cleaver O, Kimple ME, Davis DB Tags: Am J Physiol Endocrinol Metab Source Type: research
Advanced glycation end products suppress osteoblastic differentiation of stromal cells by activating endoplasmic reticulum stress.
In conclusion, AGEs inhibited the osteoblastic differentiation of stromal cells by suppressing ER stress sensors and accumulating abnormal proteins in the cells. This process might accelerate AGEs-induced suppression of bone formation found in diabetes mellitus.
PMID: 23933252 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - August 7, 2013 Category: Biochemistry Authors: Tanaka KI, Yamaguchi T, Kaji H, Kanazawa I, Sugimoto T Tags: Biochem Biophys Res Commun Source Type: research
Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 {beta}-cell line
Recently, a novel type 1 diabetes association locus was identified at human chromosome 6p31.3, and transcription factor 19 (TCF19) is a likely causal gene. Little is known about Tcf19, and we now show that it plays a role in both proliferation and apoptosis in insulinoma cells. Tcf19 is expressed in mouse and human islets, with increasing mRNA expression in nondiabetic obesity. The expression of Tcf19 is correlated with β-cell mass expansion, suggesting that it may be a transcriptional regulator of β-cell mass. Increasing proliferation and decreasing apoptotic cell death are two strategies to increase pancreatic ...
Source: AJP: Endocrinology and Metabolism - September 1, 2013 Category: Endocrinology Authors: Krautkramer, K. A., Linnemann, A. K., Fontaine, D. A., Whillock, A. L., Harris, T. W., Schleis, G. J., Truchan, N. A., Marty-Santos, L., Lavine, J. A., Cleaver, O., Kimple, M. E., Davis, D. B. Tags: Articles Source Type: research
Epigallocatechin-3-Gallate Prevents Autoimmune-Associated Down-Regulation of p21 in Salivary Gland Cells Through a p53-Independent Pathway.
In conclusion, PCNA and p21 levels are altered inversely in the NOD model for SS and in HSG cells, and warrant further study as candidate new markers for salivary dysfunction associated with xerostomia. Induction of p21 by EGCG could provide clinically useful normalization of salivary glands by promoting differentiation and reducing PCNA levels.
PMID: 24329914 [PubMed - as supplied by publisher]
Source: Inflammation and Allergy Drug Targets - December 10, 2013 Category: Allergy & Immunology Authors: Dickinson D, Yu H, Ohno S, Thomas C, Derossi S, Yat-Ho M, Yates N, Hahn E, Bisch F, Yamamoto T, Hsu S Tags: Inflamm Allergy Drug Targets Source Type: research
