Advanced glycation end products suppress osteoblastic differentiation of stromal cells by activating endoplasmic reticulum stress.

In conclusion, AGEs inhibited the osteoblastic differentiation of stromal cells by suppressing ER stress sensors and accumulating abnormal proteins in the cells. This process might accelerate AGEs-induced suppression of bone formation found in diabetes mellitus. PMID: 23933252 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23933252?dopt=Abstract

Source: Biochemical and Biophysical Research communications - August 7, 2013 Category: Biochemistry Authors: Tanaka KI, Yamaguchi T, Kaji H, Kanazawa I, Sugimoto T Tags: Biochem Biophys Res Commun Source Type: research

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