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Gene Therapy Leaves a Vicious Cycle
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research

Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity Metabolism
In conclusion, the relatively low endogenous Spl expression level in insulin-secreting cells contributes to their extraordinary vulnerability to proinflammatory cytokine toxicity and may therefore represent a promising target for β-cell protection in type 1 diabetes mellitus.
Source: Journal of Biological Chemistry - December 8, 2017 Category: Chemistry Authors: Claudine Hahn, Karolina Tyka, Julie D. Saba, Sigurd Lenzen, Ewa Gurgul-Convey Tags: Molecular Bases of Disease Source Type: research

Glycyrrhizic acid increases glucagon like peptide-1 secretion via TGR5 activation in type 1-like diabetic rats.
Abstract Glycyrrhizic acid (GA) is belonged to triterpenoid saponin that is contained in the root of licorice and is known to affect metabolic regulation. Recently, glucagon like peptide-1 (GLP-1) has widely been applied in diabetes therapeutics. However, the role of GLP-1 in GA-induced anti-diabetic effects is still unknown. Therefore, we are interested in understanding the association of GLP-1 with GA-induced effects. In type 1-like diabetic rats induced by streptozotocin (STZ-treated rats), GA increased the level of plasma GLP-1, which was blocked by triamterene at a dose sufficient to inhibit Takeda G-protein-...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 4, 2017 Category: Drugs & Pharmacology Authors: Wang LY, Cheng KC, Li Y, Niu CS, Cheng JT, Niu HS Tags: Biomed Pharmacother Source Type: research

Hyperglycemia Suppresses Calcium Phosphate-Induced Aneurysm Formation Through Inhibition of Macrophage Activation Vascular Medicine
Conclusions Our results show that hyperglycemia suppresses macrophage activation and aneurysmal degeneration through the activation of Nr1h2. Although further validation of the underlying pathway is necessary, targeting Nr1h2 is a potential therapeutic approach to treating aneurysm.
Source: JAHA:Journal of the American Heart Association - March 27, 2016 Category: Cardiology Authors: Tanaka, T., Takei, Y., Yamanouchi, D. Tags: Aneurysm Vascular Medicine Source Type: research