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Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases
Publication date: Available online 25 May 2019Source: Chemico-Biological InteractionsAuthor(s): Meenu Mehta, Deeksha, Devesh Tewari, Gaurav Gupta, Rajendra Awasthi, Harjeet Singh, Parijat Pandey, Dinesh Kumar Chellappan, Ridhima Wadhwa, Trudi Collet, Philip M. Hansbro, S Rajesh Kumar, Lakshmi Thangavelu, Poonam Negi, Kamal Dua, Saurabh SatijaAbstractOligonucleotide-based therapies are advanced novel interventions used in the management of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD). These agents primarily act by gene silencing or RNA interference. Better methodologies and te...
Source: Chemico Biological Interactions - May 26, 2019 Category: Biochemistry Source Type: research

TRPC channels mediated calcium entry is required for proliferation of human airway smooth muscle cells induced by nicotine-nAChR.
In conclusion, nicotine-induced HASMC proliferation was mediated by TRPC3-dependent calcium entry via α5-nAchR, which provided a potential target for treatment of COPD. PMID: 30550855 [PubMed - as supplied by publisher]
Source: Biochimie - December 11, 2018 Category: Biochemistry Authors: Jiang Y, Zhou Y, Peng G, Tian H, Pan D, Liu L, Yang X, Li C, Li W, Chen L, Ran P, Dai A Tags: Biochimie Source Type: research

Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.
Abstract Adipokines, a group of proteins including leptin, visfatin, resistin, and adiponectin, are produced by adipocytes. Among adipokines, resistin is implicated in insulin resistance and inflammatory response modulation. Mucus hypersecretion has been greatly linked to airway diseases, such as asthma, chronic obstructive pulmonary disease, and rhinosinusitis. Increasing evidence has indicated that adipokines, such as leptin and visfatin, play important regulatory roles in various biological processes involved in mucus secretion. However, the effects of resistin on mucin expression in human airway epithelial cel...
Source: Biochemical and Biophysical Research communications - March 28, 2018 Category: Biochemistry Authors: Kwak S, Kim YD, Na HG, Bae CH, Song SY, Choi YS Tags: Biochem Biophys Res Commun Source Type: research

Interleukin-22 attenuates double-stranded RNA-induced upregulation of PD-L1 in airway epithelial cells via a STAT3-dependent mechanism.
Abstract Double-stranded RNA derived from viruses induces host immune responses. PD-L1, also known as B7-H1, is an immune-checkpoint molecule associated with the escape of viruses from host immune systems, which plays a role in the persistence of viral infection, resulting in exacerbations of underlying diseases such as asthma and chronic obstructive pulmonary disease. Interleukin (IL)-22 is produced from various immune cells and has protective properties on mucosal tissue. The binding of IL-22 to IL-22 receptor induces STAT3 activation. We investigated the effect of IL-22 on the expression in airway epithelial ce...
Source: Biochemical and Biophysical Research communications - November 30, 2017 Category: Biochemistry Authors: Seki N, Kan-O K, Matsumoto K, Fukuyama S, Hamano S, Tonai K, Ota K, Inoue H, Nakanishi Y Tags: Biochem Biophys Res Commun Source Type: research

Anti-inflammatory effect of anti-tnf- α cationic phosphorous dendrimers nanocomplexes administered intranasally in a murine acute lung injury model.
ANTI-INFLAMMATORY EFFECT OF ANTI-TNF-α CATIONIC PHOSPHOROUS DENDRIMERS NANOCOMPLEXES ADMINISTERED INTRANASALLY IN A MURINE ACUTE LUNG INJURY MODEL. Biomacromolecules. 2017 Jun 22;: Authors: Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral JP, Mignani S, Fattal E Abstract Inflammation is an essential component of many lung diseases, including asthma, chronic obstructive pulmonary disease (COPD) or acute lung injury. Our purpose was to design efficient carriers for lung delivery of small interfering RNA (siRNA) targeting tumor necrosis factor (TNF-α) in an...
Source: Biomacromolecules - June 22, 2017 Category: Biochemistry Authors: Bohr A, Tsapis N, Andreana I, Chamarat A, Foged C, Delomenie C, Noiray M, El Brahmi N, Majoral JP, Mignani S, Fattal E Tags: Biomacromolecules Source Type: research

Cold-inducible RNA binding protein regulates mucin expression induced by cold temperatures in human airway epithelial cells.
Abstract Mucus overproduction is an important manifestation of chronic airway inflammatory diseases, however, the mechanisms underlying the association between cold air and mucus overproduction remain unknown. We found that the expression of the cold-inducible RNA binding protein (CIRP) was increased in patients with chronic obstructive pulmonary disease (COPD). In the present study, we tested whether CIRP was involved in inflammatory factors and mucin5AC (MUC5AC) expression after cold stimulation and investigated the potential signaling pathways involved in this process. We found that CIRP was highly expressed in...
Source: Archives of Biochemistry and Biophysics - May 12, 2016 Category: Biochemistry Authors: Ran D, Chen L, Xie W, Xu Q, Han Z, Huang H, Zhou X Tags: Arch Biochem Biophys Source Type: research