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High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease
In conclusion, HUA aggravated CSE-induced cellular ROS levels and led to ROS-dependent mitochondrial dynamics disorder and apoptosis in MLE-12 cells through downregulating PRDX2.PMID:37003188 | DOI:10.1016/j.intimp.2023.110056
Source: International Immunopharmacology - April 1, 2023 Category: Allergy & Immunology Authors: Ya Dong Fei Han Yue Su Bei Sun Wei Zhao Congqing Pan Source Type: research

Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis
CONCLUSION: This research suggested that H2S alleviated PM-induced emphysema and airway inflammation via restoring redox balance and inhibiting ferroptosis through regulating Nrf2-PPAR-ferritinophagy signaling pathway.PMID:35490984 | DOI:10.1016/j.freeradbiomed.2022.04.014
Source: Free Radical Biology and Medicine - May 1, 2022 Category: Biology Authors: Ying Wang Sha Liao Zihan Pan Simin Jiang Jing Fan Siwang Yu Lixiang Xue Jianling Yang Shaohua Ma Tong Liu Jing Zhang Yahong Chen Source Type: research

Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NADFormula: see text-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research

Targeting c-Src Reverses Accelerated GPX-1 mRNA Decay in COPD Airway Epithelial Cells.
Abstract Enhanced expression of the cellular antioxidant glutathione peroxidase-1 (GPX-1) prevents cigarette smoke-induced lung inflammation and tissue destruction. COPD subjects, however, have decreased airway GPX-1 levels rendering them more susceptible to disease onset and progression. The mechanisms that down regulate GPX-1 in the airway epithelium in COPD remain unknown. To ascertain these factors, analyses were conducted using human airway epithelial cells isolated from healthy and COPD human subjects and lung tissue from control and cigarette smoke exposed A/J mice. Tyrosine phosphorylation modifies GPX-1 e...
Source: American Journal of Respiratory Cell and Molecular Biology - December 3, 2019 Category: Molecular Biology Authors: Dabo AJ, Ezegbunam W, Wyman AE, Moon J, Railwah C, Lora A, Majka SM, Geraghty P, Foronjy RF Tags: Am J Respir Cell Mol Biol Source Type: research

Chaperone-mediated autophagy modulates epithelial cell apoptosis in COPD pathogenesis
Conclusion: These findings suggest that reduced CMA activity may be involved in the mechanism for epithelial cell apoptosis by enhancing CS-induced UPR in COPD pathogenesis.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Hosaka, Y., Araya, J., Fujita, Y., Tsubouchi, K., Minagawa, S., Hara, H., Nakano, T., Ito, A., Ichikawa, A., Saito, N., Kadota, T., Yoshida, M., Hashimoto, M., Numata, T., Kaneko, Y., Kuwano, K. Tags: Airway cell biology and immunopathology Source Type: research