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Circular RNA hsa_circ_0000700 promotes cell proliferation and migration in Esophageal Squamous Cell Carcinoma by sponging miR-1229
Accumulating evidence has demonstrated that circular RNAs (circRNAs) are involved in the pathogenesis of cancer, including that of esophageal squamous cell carcinoma (ESCC). The current study aimed to investigate the role of hsa_circ_0000700 in ESCC. hsa_circ_0000700, miR-1229, and related functional gene expression was measured by RT-qPCR. To characterize the functions of hsa_circ_0000700 and miR-1229, ESCC cells were infected with hsa_circ_0000700-specific siRNA, miR-1229 mimics, and an inhibitor alone or in combination. Cell Counting Kit-8 (CCK8), colony formation, EdU, flow cytometry, and Transwell assays were employed...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jun Fang, Wen Hao Ji, Fang Zheng Wang, Tie Ming Xie, Lei Wang, Zhen Fu Fu, Zhun Wang, Feng Qin Yan, Qi Liang Shen, Zhi Min Ye Tags: Research Paper Source Type: research

HIF-1 α Promotes the Metastasis of Esophageal Squamous Cell Carcinoma by Targeting SP1
Conclusion: The results of our study indicate that HIF-1α promotes metastasis of ESCC by targeting SP1 in a hypoxic microenvironment. Further study on this mechanism may elucidate the possibility of HIF-1α and SP1 as new targets for the treatment of ESCC.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xueting Hu, Jiatong Lin, Ming Jiang, Xiaotian He, Kefeng Wang, Wenjian Wang, Chuwen Hu, Zhiwen Shen, Zhanghai He, Huayue Lin, Duoguang Wu, Minghui Wang Tags: Research Paper Source Type: research

Downregulation of SPARC Expression Decreases Cell Migration and Invasion Involving Epithelial-Mesenchymal Transition through the p-FAK/p-ERK Pathway in Esophageal Squamous Cell Carcinoma
Conclusions: These results demonstrated that downregulation of SPARC could decrease cell migration and invasion involving EMT via the p-FAK/p-ERK pathway that might serve as a novel therapeutic target against ESCC.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fei Zhang, Yiyin Zhang, Jie Da, Zhenya Jia, Hongyang Wu, Kangsheng Gu Tags: Research Paper Source Type: research

Role of Kruppel-Like Factor 5 in Deoxycholic Acid-Mediated Intestinal Transdifferentiation of Esophageal Squamous Epithelium
Barrett's esophagus (BE) is an acquired condition in which normal squamous epithelium is replaced with metaplastic columnar epithelium as a consequence of gastroesophageal reflux disease. BE is known as a precursor of esophageal adenocarcinoma. Currently, the molecular mechanism underlying epithelial metaplasia in BE patients remains unknown. Therefore, we investigated the role of Krüppel-like factor 5 (KLF5) signaling in the initiation of BE-associated metaplasia. Sprague-Dawley (SD) rats were used to create a surgical model of bile reflux injury. Immunohistochemistry was performed to analyze human and mouse esophage...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yiju Xia, Yu Fang, Haoxiang Zhang, Caifei Shen, Pu Wang, Wu Yan, Jingwen Li, Yin Xu, Shunzi Shao, Yafei Zhang, Xiaona Yu, Zhihong Peng, Guiyong Peng, Wensheng Chen, Dianchun Fang Tags: Research Paper Source Type: research

Overexpression of TAF1L Promotes Cell Proliferation, Migration and Invasion in Esophageal Squamous Cell Carcinoma
Currently, it reported that TAF1L gene mutation is found in a number of carcinomas, but its pathophysiological function has not been well studied. We focused on investigating expressive levels of TAF1L gene and protein in esophageal squamous cell carcinoma (ESCC) with two tissue microarrays, forty fresh paired ESCC and paracancer samples using immunohistochemistry, real-time PCR or Western blot in this study. Furthermore, we executed TAF1L silence with siRNA in ESCC cell lines to evaluate effects of TAF1L expression on cell proliferation, migration and invasion of ESCC via CCK-8, wound healing and transwell chamber assays....
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Shan Zhong, Hongfei Yan, Zhengshan Chen, Yanpeng Li, Yanqin Shen, Yongyu Wang, Lan Li, Sitong Sheng, Yun Wang Tags: Research Paper Source Type: research

Cyclin-Dependent Kinase Inhibitor 3 Promoted Cell Proliferation by Driving Cell Cycle from G1 to S Phase in Esophageal Squamous Cell Carcinoma
Conclusions: Our study suggested that CDKN3 acted as an oncogene in human ESCC and may accelerate the G1/S transition by affecting CyclinD-CDK4 complex via regulating pAKT-p53-p21 axis and p27 independent of AKT.
Source: Journal of Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Juan Liu, Li Min, Shengtao Zhu, Qingdong Guo, Hengcun Li, Zheng Zhang, Yu Zhao, Changqin Xu, Shutian Zhang Tags: Research Paper Source Type: research

Expression and Splice Variant Analysis of Human TCF4 Transcription Factor in Esophageal Cancer
Conclusions: Our data suggested that deregulation of TCF4 isoforms may contribute to the tumorigenesis of ESCC.
Source: Journal of Cancer - June 15, 2015 Category: Cancer & Oncology Authors: Gang He, Xingying Guan, Xuedan Chen, Yan Wang, Chao Luo, Bo Zhang Tags: Research Paper Source Type: research