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Source: Journal of Cancer
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Total 78 results found since Jan 2013.
Circular RNA hsa_circ_0000700 promotes cell proliferation and migration in Esophageal Squamous Cell Carcinoma by sponging miR-1229
Accumulating evidence has demonstrated that circular RNAs (circRNAs) are involved in the pathogenesis of cancer, including that of esophageal squamous cell carcinoma (ESCC). The current study aimed to investigate the role of hsa_circ_0000700 in ESCC. hsa_circ_0000700, miR-1229, and related functional gene expression was measured by RT-qPCR. To characterize the functions of hsa_circ_0000700 and miR-1229, ESCC cells were infected with hsa_circ_0000700-specific siRNA, miR-1229 mimics, and an inhibitor alone or in combination. Cell Counting Kit-8 (CCK8), colony formation, EdU, flow cytometry, and Transwell assays were employed...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Jun Fang, Wen Hao Ji, Fang Zheng Wang, Tie Ming Xie, Lei Wang, Zhen Fu Fu, Zhun Wang, Feng Qin Yan, Qi Liang Shen, Zhi Min Ye Tags: Research Paper Source Type: research
Nodal is involved in chemoresistance of renal cell carcinoma cells via regulation of ABCB1
Renal cell carcinoma (RCC) is the third most frequent malignancy within urological oncology. Understanding mechanisms of chemoresistance in RCC cell is important for therapy and drug development. We established cisplatin (CDDP) resistant RCC cells by treating cells with increasing concentrations of CDDP. Nodal, an important embryonic morphogen, was increased in RCC/CDDP cells. Targeted inhibition of Nodal via its siRNA or neutralization antibody restored sensitivity of RCC resistant cells to CDDP treatment. It was due to that si-Nodal can decrease expression of P-glycoprotein (P-gp, encoded by ABCB1), one important ATP-bin...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Xingwang Zhu, Dongwei Xue, Jia Liu, Fengming Dong, Yongzhi Li, Yili Liu Tags: Research Paper Source Type: research
miR-369 inhibits Liver Cancer progression by targeting ZEB1 pathway and predicts the prognosis of HCC patients
Increasing evidences show that microRNAs (miRNAs) are involved in the regulation of tumorigenesis, progression, recurrence and drug resistance of hepatocellular carcinoma (HCC). miR-369 works as a tumor suppressor in both lung cancer and thyroid cancer. However, the potential biological function of miR-369 in HCC is unknown. Herein, we for first found that miR-369 expression was downregulated in HCC tissues and predicted the poor prognosis of HCC patients. Forced miR-369 expression inhibited the proliferation and metastasis of HCC cells in vitro and in vivo. Mechanically, bioinformatics and luciferase reporter analysis ide...
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Yuwei Dong, Fuxia Li, Junjun Wang, Jiangfeng Hu, Zhenghong Li, Yubei Gu, Yun Feng Tags: Research Paper Source Type: research
MiR-573 suppresses cell proliferation, migration and invasion via regulation of E2F3 in pancreatic cancer
Conclusions: MiR-573 could suppress the proliferation, migration, and invasion of pancreatic cancer cells by targeting E2F3, thereby establishing miR-573 as a novel regulator of E2F3 and indicating its critical role in tumorigenesis, especially in pancreatic cancer.
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Zhou Pengcheng, Gao Peng, Fan Haowen, Lin Xida, Lu Yuhua, Wang Yao, Zhu Mingyan, Fan Xiangjun, Wang zhiwei, Zhang Yewei, Wang Lei Tags: Research Paper Source Type: research
RNA Interference-Mediated Aurora Kinase A Gene Silencing Inhibits Human Glioma Cells Proliferation and Tumor Growth in Mice
Conclusion: Aurora A can be used as a candidate targeting gene and inhibition of Aurora A is a potentially promising therapy for glioblastoma.
Source: Journal of Cancer - April 19, 2021 Category: Cancer & Oncology Authors: Ge Zhang, Guanghui Ren, Xin Zhao, Haibo Wang Tags: Research Paper Source Type: research
Cigarette smoking promotes keratinocyte malignancy via generation of cancer stem-like cells
Conclusion: Our data suggest that smoking cigarettes promoted cancer stem-like cell generation in the head and neck area via the OCT-4/ID1/NF-κB/BMI-1 signaling pathway.
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Shuchun Lin, Wenfeng Mei, Haichun Lai, Xiufeng Li, Huanjiao Weng, Jiani Xiong, Xiuyun Lin, Tao Zeng, Qiong Zhang, Xing Liu, Yunlu Xu, Shubin Fang, Rong Jin, Xiaohua Hu, Jieming Xie, Jianbo Yang, Yiqing Zheng, Yuanzhong Chen, Jizhen Lin Tags: Research Paper Source Type: research
Long noncoding RNA DLEU2 affects the proliferative and invasive ability of colorectal cancer cells
This study sought to investigate the effects of DLEU2 on CRC pathogenesis, and the underlying mechanism involved. Using a quantitative real-time polymerase chain reaction (qRT-PCR) assay, we demonstrated that the expression levels of DLEU2 in 45 pairs of CRC tissues were higher than those in the corresponding normal colon mucosal tissues. In addition, CRC patients with high DLEU2 expression levels exhibited poor overall survival (OS) and recurrence-free survival (RFS), as determined by analyses and measurements from the GEO and GEPIA databases. When DLEU2 was silenced using short interfering RNA (siRNA) in CRC cell line, t...
Source: Journal of Cancer - January 15, 2021 Category: Cancer & Oncology Authors: Xiaoyun He, Bingbing Yu, Gaoyan Kuang, Yongrong Wu, Meili Zhang, Pengfei Cao, Chunlin Ou Tags: Research Paper Source Type: research
Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells
Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2 (MDM2) and murine double minute X (MDMX) inhibitor in reversing the DOX resistance of BC. Both DOX-resistant human breast carcinoma cell lines exhibited a multidrug resistance (MDR) phenotype. The ability of the dual-target MDM2/MDMX inhibitor in reversing doxorubicin resistance was subsequently verified, (9....
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Yangwei Fan, Ke Ma, Jiayu Jing, Chuying Wang, Yuan Hu, Yu Shi, Enxiao Li, Qianqian Geng Tags: Research Paper Source Type: research
HIF-1 α Promotes the Metastasis of Esophageal Squamous Cell Carcinoma by Targeting SP1
Conclusion: The results of our study indicate that HIF-1α promotes metastasis of ESCC by targeting SP1 in a hypoxic microenvironment. Further study on this mechanism may elucidate the possibility of HIF-1α and SP1 as new targets for the treatment of ESCC.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Xueting Hu, Jiatong Lin, Ming Jiang, Xiaotian He, Kefeng Wang, Wenjian Wang, Chuwen Hu, Zhiwen Shen, Zhanghai He, Huayue Lin, Duoguang Wu, Minghui Wang Tags: Research Paper Source Type: research
Aberrant CDK9 expression within chordoma tissues and the therapeutic potential of a selective CDK9 inhibitor LDC000067
Conclusion: We demonstrate that CDK9 expression in chordoma correlates with patient outcome, and, when inhibited, chordoma cell growth and proliferation significantly decreases. Taken together, these results support CDK9 as an emerging potential target in chordoma therapy.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Shen Shen, Dylan C. Dean, Zujiang Yu, Francis Hornicek, Quancheng Kan, Zhenfeng Duan Tags: Research Paper Source Type: research
Nedaplatin reduces multidrug resistance of non-small cell lung cancer by downregulating the expression of long non-coding RNA MVIH
In conclusion, LncRNA MVIH is upregulated in drug resistant NSCLC cells. Nedaplatin can reduce the expression of MVIH and reverse EMT process, thus reversing the drug resistance of cisplatin in non-small cell lung cancer cells.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Changwen Jing, Zhuo Wang, Rui Lou, Jianzhong Wu, Chen Shi, Dan Chen, Rong Ma, Siwen Liu, Haixia Cao, Jifeng Feng Tags: Research Paper Source Type: research
Tankyrases/ β -catenin Signaling Pathway as an Anti-proliferation and Anti-metastatic Target in Hepatocarcinoma Cell Lines
Conclusion: The TNKS/β-catenin signaling pathway is a potential anti-proliferation and anti-metastatic target in HCC.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Jianghai Huang, Qiang Qu, Yong Guo, Yuqi Xiang, Deyun Feng Tags: Research Paper Source Type: research
Downregulation of SPARC Expression Decreases Cell Migration and Invasion Involving Epithelial-Mesenchymal Transition through the p-FAK/p-ERK Pathway in Esophageal Squamous Cell Carcinoma
Conclusions: These results demonstrated that downregulation of SPARC could decrease cell migration and invasion involving EMT via the p-FAK/p-ERK pathway that might serve as a novel therapeutic target against ESCC.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Fei Zhang, Yiyin Zhang, Jie Da, Zhenya Jia, Hongyang Wu, Kangsheng Gu Tags: Research Paper Source Type: research
Long Noncoding RNA DCST1-AS1 Promotes Cell Proliferation and Metastasis in Triple-negative Breast Cancer by Forming a Positive Regulatory Loop with miR-873-5p and MYC
Conclusions: DCST1-AS1 is activated by MYC and is degraded by binding to miR-873-5p, thereby upregulating the expression of miR-873-5p downstream proteins IGF2BP1, MYC, LEF1 and CD44. MYC, DCST1-AS1 and miR-873-5p form a positive regulatory loop to promote TNBC cell proliferation and metastasis.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Li Tang, Yuli Chen, Xun Tang, Da Wei, Xinyu Xu, Feng Yan Tags: Research Paper Source Type: research
Nicotine Upregulates the Level of Mcl-1 through STAT3 in H1299 Cells
Conclusions: We have demonstrated that nicotine induces up-regulation of Mcl-1 through STAT3, which process may be independent on JAKs and not only dependent on the phosphorylation of Y705. Downregulation of Mcl-1 transcription by inhibiting STAT3 cascade may be a potential strategy for the treatment of this cancer.
Source: Journal of Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Maojun Zhou, Jinfeng Zhao, Qi Zhang, Xin Jin, Mingmei Liao, Lihua Zhang, Jiwei Wang, Manyi Yang Tags: Research Paper Source Type: research
