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APE1 redox function is required for activation of Yes-associated protein 1 under reflux conditions in Barrett's-associated esophageal adenocarcinomas
CONCLUSION: Our findings established a novel function of APE1 in EAC progression elucidating druggable molecular vulnerabilities via targeting APE1 or YAP1 for the treatment of EAC.PMID:36045416 | DOI:10.1186/s13046-022-02472-5
Source: Clin Med Res - August 31, 2022 Category: Research Authors: Farah Ballout Heng Lu Lei Chen Kannappan Sriramajayam Jianwen Que Zhipeng Meng Timothy C Wang Silvia Giordano Alexander Zaika Oliver McDonald Dunfa Peng Wael El-Rifai Source Type: research

Role of Kruppel-Like Factor 5 in Deoxycholic Acid-Mediated Intestinal Transdifferentiation of Esophageal Squamous Epithelium
Barrett's esophagus (BE) is an acquired condition in which normal squamous epithelium is replaced with metaplastic columnar epithelium as a consequence of gastroesophageal reflux disease. BE is known as a precursor of esophageal adenocarcinoma. Currently, the molecular mechanism underlying epithelial metaplasia in BE patients remains unknown. Therefore, we investigated the role of Krüppel-like factor 5 (KLF5) signaling in the initiation of BE-associated metaplasia. Sprague-Dawley (SD) rats were used to create a surgical model of bile reflux injury. Immunohistochemistry was performed to analyze human and mouse esophage...
Source: Journal of Cancer - December 14, 2019 Category: Cancer & Oncology Authors: Yiju Xia, Yu Fang, Haoxiang Zhang, Caifei Shen, Pu Wang, Wu Yan, Jingwen Li, Yin Xu, Shunzi Shao, Yafei Zhang, Xiaona Yu, Zhihong Peng, Guiyong Peng, Wensheng Chen, Dianchun Fang Tags: Research Paper Source Type: research

In oesophageal squamous cells, nitric oxide causes S-nitrosylation of Akt and blocks SOX2 (sex determining region Y-box 2) expression
Conclusions In oesophageal squamous cells, NO blocks SOX2 expression through Akt S-nitrosylation. NO also increases CDX2 and decreases p63 expression. By triggering molecular events preventing squamous differentiation while promoting intestinal differentiation, NO might contribute to Barrett's pathogenesis.
Source: Gut - August 8, 2016 Category: Gastroenterology Authors: Asanuma, K., Huo, X., Agoston, A., Zhang, X., Yu, C., Cheng, E., Zhang, Q., Dunbar, K. B., Pham, T. H., Wang, D. H., Iijima, K., Shimosegawa, T., Odze, R. D., Spechler, S. J., Souza, R. F. Tags: Oesophageal cancer Oesophagus Source Type: research

Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca2+ in FLO cells, an increase that is blocked by Ca2+-free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of intrac...
Source: AJP: Gastrointestinal and Liver Physiology - May 15, 2014 Category: Gastroenterology Authors: Li, D., Cao, W. Tags: CANCER BIOLOGY Source Type: research

Role Of Intracellular Calcium And NADPH Oxidase NOX5-S In Acid-Induced DNA Damage In Barrett's cells and Barrett's Esophageal Adenocarcinoma Cells.
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca(2+) in FLO cells, an increase which is blocked by Ca(2+) free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of i...
Source: Am J Physiol Gastroi... - April 3, 2014 Category: Gastroenterology Authors: Li D, Cao W Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research