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Downregulation of Rap1GAP Expression Activates the TGF- < em > β < /em > /Smad3 Pathway to Inhibit the Expression of Sodium/Iodine Transporter in Papillary Thyroid Carcinoma Cells
CONCLUSION: The downregulation of Rap1GAP expression can activate the TGF-β/Smad3 pathway to inhibit NIS expression and alter the tumor cell functions of PTC.PMID:34840979 | PMC:PMC8616680 | DOI:10.1155/2021/6840642
Source: Biomed Res - November 29, 2021 Category: Research Authors: Zheng Yan Wang Yangyanqiu Han Shuwen Mao Jing Liao Haihong Chen Gong Jin Yin Zhou Qing Gao Weili Source Type: research

NR2F1 mediated down-regulation of osteoblast differentiation was rescued by bone morphogenetic protein-2 (BMP-2) in human MSC.
This study aimed to identify alterations in signaling networks mediated by NR2F1 in osteoblast differentiation. siRNA-mediated down-regulation of NR2F1 leads to impairment in the differentiation of hBMSC-TERT to osteoblast; gene-expression results confirmed the down-regulation of osteoblast markers such as RUNX2, ALPL, OSC, and BSP. Global whole gene expression analysis revealed that most down-regulated genes were associated with osteoblast differentiation (DDIT3, BMP2). Pathway analysis revealed prominent signaling pathways that were down-regulated, including the TGFβ pathway and MAPK pathway. Functional studies on NR2F1...
Source: Differentiation - October 29, 2018 Category: Research Authors: Manikandan M, Abuelreich S, Elsafadi M, Alsalman H, Almalak H, Siyal A, Hashmi JA, Aldahmash A, Kassem M, Alfayez M, Mahmood A Tags: Differentiation Source Type: research

A potential role for the Hippo pathway protein, YAP, in controlling proliferation, cell cycle progression, and autophagy in BCPAP and KI thyroid papillary carcinoma cells.
CONCLUSIONS: In papillary thyroid cancer YAP protein expression is positively correlated with the extent of TNM stage and positive lymph node metastasis. In thyroid cancer cell lines YAP appears to be important in stimulating cell proliferation while inhibiting autophagy. PMID: 28804541 [PubMed]
Source: American Journal of Translational Research - August 15, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Targeting TGF- β1 suppresses survival of and invasion by anaplastic thyroid carcinoma cells.
CONCLUSIONS: Targeting TGF-β1 may be effective in inhibiting primary tumor formation, but not metastasis, by ATC cells. TGF-β1 inhibition in combination with other tumor-targeted therapies may be more effective in inhibiting ATC. PMID: 28386367 [PubMed]
Source: American Journal of Translational Research - April 9, 2017 Category: Research Tags: Am J Transl Res Source Type: research

Iodine-131 treatment of thyroid cancer cells leads to suppression of cell proliferation followed by induction of cell apoptosis and cell cycle arrest by regulation of B-cell translocation gene 2-mediated JNK/NF- κB pathways.
This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured and treated with 131I. They were then assessed for 131I uptake, cell viability, apoptosis, cell cycle arrest, p53 expression, and BTG2 gene expression. SW579 cells were transfected with BTG2 siRNA, p53 siRNA and siNC and were then examined for the same aforementioned parameters. When treated with a JNK inhibitor of SP600125 and 131I or with a NF-κB inhibitor of BMS-345541 and 131I, non-transfected SW57...
Source: Brazilian Journal of Medical and Biological Research - January 19, 2017 Category: Research Tags: Braz J Med Biol Res Source Type: research

Effect of Slug-Mediated Down-Regulation of E-Cadherin on Invasiveness and Metastasis of Anaplastic Thyroid Cancer Cells.
CONCLUSIONS Targeting Slug signaling pathway is effective in preventing lung metastasis in ATC. PMID: 28070118 [PubMed - in process]
Source: Medical Science Monitor - January 13, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Targeting Transforming Growth Factor-Beta1 (TGF-β1) Inhibits Tumorigenesis of Anaplastic Thyroid Carcinoma Cells Through ERK1/2-NFκkB-PUMA Signaling.
CONCLUSIONS Therapies targeting the TGF-β1 pathway may be more effective to prevent primary tumor formation. The ability of this therapy to decrease tumorigenesis may be related to ERK1/2/NF-κB/PUMA signaling. PMID: 27356491 [PubMed - in process]
Source: Medical Science Monitor - July 1, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Targeting TGF-β1 inhibits invasion of anaplastic thyroid carcinoma cell through SMAD2-dependent S100A4-MMP-2/9 signalling.
CONCLUSIONS: Therapies targeting the TGF-β1 inhibits invasion of ATC cells by impeding the SMAD2-dependent S100A4-MMP-2/9 signalling in vitro. PMID: 27347327 [PubMed]
Source: American Journal of Translational Research - June 29, 2016 Category: Research Tags: Am J Transl Res Source Type: research

Microrna-199a-5p Functions as a Tumor Suppressor via Suppressing Connective Tissue Growth Factor (CTGF) in Follicular Thyroid Carcinoma.
CONCLUSIONS Our study proves that the CTGF gene is a target of miR-199a-5p, demonstrating the negatively related association between CTGF and miR-199a. These findings suggest that miR-199a-5p might be a novel therapeutic target in the treatment of follicular thyroid carcinoma. PMID: 27062921 [PubMed - in process]
Source: Medical Science Monitor - April 13, 2016 Category: Research Tags: Med Sci Monit Source Type: research