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GSE242834 Gene expression profiling and the effect of HDAC9 in cisplatin resistance of esophageal squamous cell carcinoma
Series Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensEsophageal cancer is one of the most serious health problems globally because of its high incidence and mortality rate. Cisplatin(CDDP) is the primary treatment but limited by the drug resistance. However, the mechanism of cisplatin resistance remains unclear. Herein, the CDDP-resistant cell line TE-1/CDDP was established to compared with TE-1, the expression profiles of circRNAs were compared between TE-1/CDDP and TE-1 using microarray analysis, Histone deacetylase 9(HDAC9) was identified significantly up-regulated. Using siRNA and conducting cell funct...
Source: GEO: Gene Expression Omnibus - September 14, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research

GSE146975 EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer
Contributors : Michael Rose ; Bernd Denecke ; Nadine T GaisaSeries Type : Expression profiling by arrayOrganism :Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle invasive bladder cancer (MIBC). However, impact on bladder cancer with substantial squamous differentiated (Sq-BLCA) and especially pure squamous cell carcinoma (SCC) remains unknown. Therefore, we comprehensively characterized pure and mixed Sq-BLCA (n=125) on genetic and protein expression level, and performed functional pathway and drug-response analyses with cell line models and isolated primary SCC (p-SCC) cells of the human urin...
Source: GEO: Gene Expression Omnibus - March 12, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research

GSE206845 Effect of depletion of USP36 on gene expression of ECA109 cells, esophageal squamous cell carcinoma cell line.
Contributors : Wenhao Zhang ; Xiaogang Zhao ; Jian ZhuSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the function of USP36 in the regulation of cell proliferation and escc progression, we established eca109 cell lines in which each target gene has been knocked down by siRNA.We then performed gene expression profiling analysis using data obtained from RNA-seq of 6 different cells at same time points.
Source: GEO: Gene Expression Omnibus - January 4, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE140966 RNA-Seq profiling of circular RNAs and the oncogenic role of circPVT1 in cutaneous squamous cell carcinoma
Contributors : Shuang Chen ; Chundi HeSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCircular RNAs(circRNAs),which are a type of non-coding RNA with a special structure, have attracted the attention of researchers in recent years.As a high throughput gene screening method, RNA-seq has been widely used in tumor research.In present study,we assessed the expression pattern of circRNAs in CSCC via RNA-seq on CSCC and matched paracancerous samples. We further identified circPVT1 as being overexpressed in CSCC tissues and cells.Subsequently, we identified the characteristics of circPVT1 in...
Source: GEO: Gene Expression Omnibus - November 24, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Gallic Acid has an inhibitory effect on skin squamous cell carcinoma and acts on the heat shock protein HSP90AB1
Gene. 2022 Nov 11:147041. doi: 10.1016/j.gene.2022.147041. Online ahead of print.ABSTRACTDifferences in the features of aggressiveness of non-melanoma skin cancer (NMSC) subtypes, between basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are relevant characteristics. Comparing the characteristics between NMSC subtypes might help identify molecules associated with cancer metastasis and invasion. Considering these facts, the current study aimed to identify a molecular target for inhibiting skin cancer metastasis and invasion. Proteomic analysis suggested that heat shock protein 90 kDa, alpha, class B member 1 (HSP...
Source: Gene - November 14, 2022 Category: Genetics & Stem Cells Authors: Sabrina Ferreira de Jesus Marcela Gon çalves de Souza Lorena Dos Reis Pereira Queiroz Daniela Paola Santos de Paula Angeliny Tamiarana Lima Tabosa Wislene Sarajane Moreira Alves Luiz Henrique da Silveira Andr é Teixeira da Silva Ferreira Ozires Jos é D Source Type: research

GSE161226 HEDGEHOG/GLI Modulates The PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas
Contributors : Yiyun Sun ; Ying ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe previously demonstrated that proline-rich protein 11 (PRR11) and spindle and kinetochore associated 2 (SKA2) constituted a head-to-head gene pair driven by a prototypical bidirectional promoter, and this gene pair synergistically promoted the development of non-small-cell lung cancer. However, the signaling pathways leading to the ectopic expression of this gene pair remain obscure. In the present study, we first analyzed the lung squamous cell carcinoma (LSCC) relevant RNA sequencing data from the...
Source: GEO: Gene Expression Omnibus - November 10, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE210922 FOXM1-mediated regulation of reactive oxygen species and radioresistance in oral squamous cell carcinoma cells
Contributors : Hisashi Takeshita ; Ryoji Yoshida ; Junki Inoue ; Mayumi Hirayama ; Toru Oyama ; Ryuta Kubo ; Keisuke Yamana ; Yuka Nagao ; Shunsuke Gohara ; Junki Sakata ; Masatoshi Hirayama ; Kenta Kawahara ; Nozomu Takahashi ; Akiyuki Hirosue ; Yoshikazu Kuwata ; Manabu Fukumoto ; Ryo Toya ; Ryuji Murakami ; Hideki NakayamaSeries Type : Expression profiling by arrayOrganism : Homo sapiensRadioresistance is a major obstacle to the successful treatment of oral squamous cell carcinoma (OSCC). To help overcome this issue, we have developed clinically relevant radioresistant (CRR) cell lines, generated by irradiating parental...
Source: GEO: Gene Expression Omnibus - October 1, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE205981 RNA-Seq analysis of cSCC cells followed by siRNA-induced gene knockdown of lncRNA LINC00094 (SERLOC)
Contributors : Minna Piipponen ; Liisa Nissinen ; Veli-Matti K ähäriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKeratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing globally. Long non-coding RNAs (lncRNAs) are involved in various biological processes, and their role in cancer progression is emerging. Whole transcriptome analysis of cSCC cells (n=8) and normal human epidermal keratinocytes (NHEKs, n=4) revealed overexpression of long intergenic ncRNA (LINC00094) in cSCC cells (GSE66412). We wanted...
Source: GEO: Gene Expression Omnibus - August 29, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE174626 mRNA-Seq analysis of cSCC cells followed by siRNA-induced gene knockdown of C1r.
Contributors : Kristina Viiklepp ; Liisa Nissinen ; Veli-Matti K ähäriSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensKeratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, and its incidence is increasing globally. Chronic inflammation has been recognized as a risk factor for cSCC and inflammation is a typical feature in the progression of premalignant actinic keratosis lesions to invasive and metastatic cSCC. The complement system is an important part of innate immunity, and activation of complement is detected in the microenvironme...
Source: GEO: Gene Expression Omnibus - November 17, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE183926 Differentially expressed genes after transfection of siRNA in human cancer cell lines
Contributors : Naohiko Seki ; Kengo TanigawaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by siRNAs transfection in human cancer, lung squamous cell carcinoma cell lines were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - September 11, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE178669 Next Generation Sequencing Facilitates Quantitative Analysis of Control siRNA, RAB11A siRNA1 and RAB11A siRNA2 suppressed EBC-1 cell's Transcriptomes
This study aims to find cellular pathway changes in RAB11A suppressed in lung squamous cell carcinoma cell line EBC-1 compared to control and to evaluate downregulating genes by RAB11A suppression by siRNA. Total RNA was extracted from EBC-1 transfected with control siRNA and RAB11A specific siRNAs using the RNeasy mini kit (Qiagen, Hilden, Germany). CAGE library preparation, sequencing, mapping, and gene expression and motif discovery analysis were performed by DNAFORM (Yokohama, Japan). In brief, RNA quality was assessed by Bioanalyzer (Agilent) to ensure that RIN (RNA integrity number) is over 7.0 and A260/280 and 260/2...
Source: GEO: Gene Expression Omnibus - June 23, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Genes, Vol. 12, Pages 120: HEDGEHOG/GLI Modulates the PRR11-SKA2 Bidirectional Transcription Unit in Lung Squamous Cell Carcinomas
Bu Ying Zhang We previously demonstrated that proline-rich protein 11 (PRR11) and spindle and kinetochore associated 2 (SKA2) constituted a head-to-head gene pair driven by a prototypical bidirectional promoter. This gene pair synergistically promoted the development of non-small cell lung cancer. However, the signaling pathways leading to the ectopic expression of this gene pair remains obscure. In the present study, we first analyzed the lung squamous cell carcinoma (LSCC) relevant RNA sequencing data from The Cancer Genome Atlas (TCGA) database using the correlation analysis of gene expression and gene set enrichm...
Source: Genes - January 19, 2021 Category: Genetics & Stem Cells Authors: Yiyun Sun Dandan Xu Chundong Zhang Yitao Wang Lian Zhang Deqian Qiao Youquan Bu Ying Zhang Tags: Article Source Type: research

GSE143803 SREBF1 coordinates with master transcription factors in regulating lipid metabolism and cancer-promoting pathways in squamous cell carcinoma
Contributors : Liyan Li ; Qian Yang ; Yanyi Jiang ; Wei Yang ; Yuan Jiang ; Masaharu Hazawa ; Bo Zhou ; Xiang Li ; Sigal Gery ; Lingwen Ding ; Allen S Ho ; Zachary S Zumsteg ; Mingrong Wang ; Yanbing Ding ; Stephen J Freedland ; Liyan Xu ; Enmin Li ; H P Koeffler ; Dechen LinSeries Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensWe profiled esophageal squamous cell carcinorma (ESCC) cell lines with chromatin immunoprecipitation sequencing (ChIP-Seq). Mathematically modeling was performed to establish (super)-enhancers landsca...
Source: GEO: Gene Expression Omnibus - June 15, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE150044 Hippo pathway induces PIEZO1 expression to promote oral squamous cell carcinoma cell proliferation
Contributors : Kana Hasegawa ; Shinsuke Fujii ; Yudai Tajiri ; Tamotsu KiyoshimaSeries Type : Expression profiling by arrayOrganism : Homo sapiensMost cancer cells are exposed to extracellular environments, such as extracellular matrix, which commonly becomes stiffer along with transformation. It is conceivable that tumorous extracellular environments would be changing to affect tumor cell behavior. It has been reported that Hippo pathway responds to the extracellular environments and induces the nuclear localization of transcription activator, yes-associated protein (YAP), resulting in stimulating cell proliferation. Its ...
Source: GEO: Gene Expression Omnibus - May 8, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

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