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Cancer: Fibrosarcoma

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Total 19 results found since Jan 2013.

mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in Psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells.
In conclusion, mTOR inactivation by ROS-JNK-p53 pathway played an important role in autophagy-dependent senescence in PAB-treated L929 cells. PMID: 23810968 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - June 26, 2013 Category: Drugs & Pharmacology Authors: Qi M, Zhou H, Fan S, Li Z, Yao G, Tashiro SI, Onodera S, Xia M, Ikejima T Tags: Eur J Pharmacol Source Type: research

Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration
Conclusions: Providing first evidence of a cell biological function of CT45, we suggest that this cancer/testis antigen is involved in the modulation of cell morphology, cell adherence and cell motility. Enhanced motility and/or invasiveness of CT45-positive cells could contribute to the more severe disease progression that is correlated to CT45-positivity in several malignancies.
Source: Cell Communication and Signaling - June 10, 2013 Category: Molecular Biology Authors: Anja KoopNadia SellamiSabine Adam-KlagesMarcus LettauDieter KabelitzOttmar JanssenHans-Jürgen Heidebrecht Source Type: research

The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion
Conclusions: These results indicate that patupilone counteracts an IR-induced MMP activation process by the reduction of secreted TIMP-1 and TIMP-2 proteins, which are required for activation of MMPs. Since IR-induced MMP activity could contribute to tumor progression, treatment combination of IR with patupilone might be of great clinical benefit for tumor therapy.
Source: Radiation Oncology - April 30, 2013 Category: Cancer & Oncology Authors: Polina Furmanova-HollensteinAngela Broggini-TenzerMatthias EggelAnne-Laure MillardMartin Pruschy Source Type: research

Regulation of Mitophagy by the Gp78 E3 Ubiquitin Ligase.
This study therefore describes a novel role for the ER-associated Gp78 ubiquitin ligase and the Mfn1 mitochondrial fusion factor in mitophagy. PMID: 23427266 [PubMed - as supplied by publisher]
Source: Mol Biol Cell - February 20, 2013 Category: Molecular Biology Authors: Fu M, Pierre PS, Shankar J, Wang PT, Joshi B, Nabi IR Tags: Mol Biol Cell Source Type: research