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Knocking down Siglec-15 in osteosarcoma cells inhibits proliferation while promoting apoptosis and pyroptosis by targeting the Siglec-15/STAT3/Bcl-2 pathway
CONCLUSIONS: In this study, we demonstrated that the ablation of Siglec-15 in osteosarcoma inhibited proliferation and promoted apoptosis and pyroptosis by targeting the Siglec-15/STAT3/Bcl-2 pathway.PMID:35398779 | DOI:10.1016/j.advms.2022.03.001
Source: Advances in Medical Sciences - April 10, 2022 Category: Biomedical Science Authors: Keliang Song Jinfeng Ma Yang Gao Yan Qu Chongmin Ren Peng Yan Bingxin Zheng Bin Yue Source Type: research

Local anesthetic levobupivacaine inhibits stemness of osteosarcoma cells by epigenetically repressing MAFB though reducing KAT5 expression
In this study, we identified that the treatment of levobupivacaine suppressed proliferation of osteosarcoma cells in vitro. The tumor xenograft analysis showed that levobupivacaine significantly repressed the osteosarcoma cell growth in the nude mice. The treatment of levobupivacaine improved the apoptosis rate and attenuated invasion and migration abilities of osteosarcoma cells. The sphere formation capabilities of osteosarcoma cells were repressed by levobupivacaine. The protein levels of Sox-2, Oct3/4, and Nanog were inhibited by the treatment of levobupivacaine in osteosarcoma cells. Regarding mechanism, we identified...
Source: Aging - March 25, 2022 Category: Biomedical Science Authors: Zhan Wang Yuxin Song Hui Zhang Yang Yang Suifeng Zhang Wenji Wang Source Type: research

LncRNA RUSC1-AS1 promotes osteosarcoma progression through regulating the miR-340-5p and PI3K/AKT pathway
In conclusion, our study demonstrated that RUSC1-AS1 promoted osteosarcoma development both in vitro and in vivo through sponging to miR-340-5p and activating the PI3K/AKT signaling pathway. Therefore, RUSC1-AS1 becomes a potential therapeutic target for osteosarcoma.PMID:34048366 | DOI:10.18632/aging.203047
Source: Aging - May 28, 2021 Category: Biomedical Science Authors: Chang-Jun Tong Qing-Chun Deng Di-Jun Ou Xia Long He Liu Kang Huang Source Type: research

Silencing microRNA-27a inhibits proliferation and invasion of human osteosarcoma cells through the SFRP1-dependent Wnt/ β-catenin signaling pathway.
This study aims to discuss effects of miR-27a and its target gene secreted frizzled related protein 1 (SFRP1) on proliferation and invasion of human osteosarcoma cells via Wnt/β-catenin signaling pathway. The expression of miR-27a and SFRP1 in osteosarcoma tissues and cells was detected, followed by identification of their relations. Subsequently, miR-27a mimic, miR-27a inhibitor, or siRNA against SFRP1 were introduced into cells (HOS and U2OS) to investigate their role in cell proliferation and invasion. The expression of Wnt/β-catenin signaling pathway-related gene was analyzed to further uncover the regulatory mechani...
Source: Bioscience Reports - May 8, 2019 Category: Biomedical Science Authors: Mu Y, Zhang L, Chen X, Chen S, Shi Y, Li J Tags: Biosci Rep Source Type: research

Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis.
Abstract Naringin, a citrus bioflavonoid, has anti-inflammatory actions and cardio- and neuroprotective effects. In addition, naringin exhibits multiple antitumor actions in several cancer types, including osteosarcoma, the most common type of bone cancer. Here, we show that naringin inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1), a transcriptional repressor of epithelial differentiation involved in tumor metastasis. Our expression analyses confirm that Zeb1 is highly expressed in osteosarcoma specimens and cell lines....
Source: Aging - December 22, 2018 Category: Biomedical Science Authors: Ming H, Chuang Q, Jiashi W, Bin L, Guangbin W, Xianglu J Tags: Aging (Albany NY) Source Type: research

Long non-coding RNA NEAT1 promotes proliferation, migration and invasion of human osteosarcoma cells.
Conclusion: LncRNA NEAT1 was up-regulated in osteosarcoma tissue, promoting proliferation and metastasis of osteosarcoma cells. These findings indicate the role of this substance, as a growth regulator in osteosarcoma, and thus it may serve as a novel biomarker, and drug target for developing osteosarcoma therapies. PMID: 30123061 [PubMed - in process]
Source: International Journal of Medical Sciences - August 21, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research