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Role of vasodilator-stimulated phosphoprotein in RANKL-differentiated murine macrophage RAW264.7 cells: Modulation of NF- κB, c-Fos and NFATc1 transcription factors
Exp Ther Med. 2021 May;21(5):412. doi: 10.3892/etm.2021.9856. Epub 2021 Feb 25.ABSTRACTVasodilator-stimulated phosphoprotein (VASP) is essential for osteoclast differentiation, and reduced VASP expression results in depressed osteoclast differentiation. Previously, we demonstrated the importance of VASP and Ras-related C3 botulinum toxin substrate 1 interactions in osteosarcoma cell migration and metastasis using Mg-63 and Saos2 cells. However, the molecular details of the functional role of VASP in cell motility and migration remain to be elucidated. The present study demonstrated that VASP affects the expression of αV-i...
Source: Experimental and Therapeutic Medicine - March 22, 2021 Category: General Medicine Authors: Hao Hu Chao Li Haitao Zhang Gang Wu Yong Huang Source Type: research

EP1 receptor is involved in prostaglandin E2-induced osteosarcoma growth.
Authors: Niu JC, Ma N, Liu W, Wang PJ Abstract Recent studies showed that the activation of prostaglandin (PG) receptor EP1 promotes cell migration and invasion in different cancers. The aim of this study was to investigate the role of EP1 in the proliferation of osteosarcoma (OS) cells in vitro and in vivo. EP1 mRNA and protein levels were analyzed by real-time RT-PCR and Western blot, respectively in human OS cell lines MG63, OS732, U-2OS, HOS and SAOS-2 compared to human fetal osteoblastic hFOB 1.19 cells. MG63 cells were treated with PGE2, EP1 specific agonist 17-PT-PGE2, 17-PT-PGE2 + EP1 specific antagonist SC...
Source: Bosnian Journal of Basic Medical Sciences - April 19, 2019 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma.
Conclusions: We found that inhibition of autophagy, either by autophagy inhibitors or ATG gene knockdown, markedly enhances TSA-caused cell death. Taken together, our studies reveal the function of autophagy in HDACI-caused osteosarcoma cell death and thus support the development of a novel therapeutic strategy by combining HDACIs and autophagy inhibitors in osteosarcoma treatment. PMID: 30697272 [PubMed]
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

siRNA-mediated downregulation of GluN2B in the rostral anterior cingulate cortex attenuates mechanical allodynia and thermal hyperalgesia in a rat model of pain associated with bone cancer.
Authors: Xu Y, Wang G, Zou X, Yang Z, Wang Q, Feng H, Zhang M Abstract It has previously been suggested that the upregulation of GluN2B-containing N-methyl D-aspartate receptors (GluN2B) within the rostral anterior cingulate cortex (rACC) may contribute to the development of chronic pain. The present study used a rat model of bone cancer pain in order to investigate whether lentiviral-mediated delivery of small interfering RNAs targeting GluN2B (LV-GluN2B) could attenuate pain associated with bone cancer, by selectively decreasing GluN2B expression within the rACC. Sprague Dawley rats were inoculated with osteosarc...
Source: Experimental and Therapeutic Medicine - February 20, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

MicroRNA-21 regulates the sensitivity to cisplatin in a human osteosarcoma cell line
Conclusion The miR-21 in osteosarcoma cells is a significant modulator of the anti-tumor effect of CDDP by regulating the expression of bcl-2, and the study reveals a novel mechanism of osteosarcoma drug resistance.
Source: Irish Journal of Medical Science - January 12, 2016 Category: Journals (General) Source Type: research