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TOSO interacts with SYK and enhances BCR pathway activation in chronic lymphocytic leukemia.
CONCLUSIONS: TOSO might be involved in the pathogenesis of CLL by interacting with SYK, enhancing the BCR signaling pathway, and inducing apoptosis resistance. PMID: 32784334 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - August 9, 2020 Category: General Medicine Authors: Zhang YR, Yu Z, Xiong WJ, Liu XX, Liu HM, Cui R, Wang Q, Chen WM, Qiu LG, Yi SH Tags: Chin Med J (Engl) Source Type: research

Downregulation of miRNA-663b protects against hypoxia-induced injury in cardiomyocytes by targeting BCL2L1.
In conclusion, miR-663b inhibition protected cardiomyocytes against hypoxia-induced injury by targeting BCL2L1 and may potentially be a novel target for the treatment of patients with myocardial infarction. PMID: 32346421 [PubMed]
Source: Experimental and Therapeutic Medicine - April 30, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

MALAT1 inhibits the Wnt/ β-catenin signaling pathway in colon cancer cells and affects cell proliferation and apoptosis.
MALAT1 inhibits the Wnt/β-catenin signaling pathway in colon cancer cells and affects cell proliferation and apoptosis. Bosn J Basic Med Sci. 2019 Nov 15;: Authors: Zhang J, Li Q, Xue B, He R Abstract Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is a highly conserved long noncoding RNA, which has been related to various pathological processes, including cancer. The role and mechanism of MALAT1 in colon cancer are not clear. We investigated MALAT1 expression in colon cancer tissues, the effect of MALAT1 on proliferation and apoptosis of SW480 cells, and the signaling pathway involved...
Source: Bosnian Journal of Basic Medical Sciences - November 19, 2019 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

miR-210-3p regulates the proliferation and apoptosis of non-small cell lung cancer cells by targeting SIN3A.
Authors: Ren J, Li X, Dong H, Suo L, Zhang J, Zhang L, Zhang J Abstract Previous studies have indicated that microRNA (miR)-210-3p is upregulated in NSCLC, however, the specific mechanism underlying the role of miR-210-3p in NSCLC pathogenesis requires further investigation. The aim of the present study was to explore the roles of miR-210-3p in NSCLC and the associated mechanisms. A total of 30 NSCLC tissues and paired adjacent normal tissues were collected for study. Reverse transcription-quantitative polymerase chain reaction was performed to compare the expression of miR-210-3p in the 30 paired cancerous and adj...
Source: Experimental and Therapeutic Medicine - September 28, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Downregulation of miR-3934-5p enhances A549 cell sensitivity to cisplatin by targeting TP53INP1.
Authors: Ren A, Wen Z, Zheng L Abstract Tumor protein p53-inducible nuclear protein 1 (TP53INP1) is a tumor suppressor associated with malignant tumor metastasis. In addition, it has been reported that hsa-microRNA (miR)-3934 serves key roles in various types of lung cancer, including small-cell lung carcinomas (SCLC) and non-SCLC (NSCLC). Therefore, the present study aimed to determine the effects of miR-3934-5p on cell proliferation and apoptosis, and on sensitivity to cisplatin (DDP). Reverse transcription-quantitative polymerase chain reaction analysis and western blotting were conducted for the analysis of mRN...
Source: Experimental and Therapeutic Medicine - August 16, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Knockdown of lncRNA-HOTAIR downregulates the drug-resistance of breast cancer cells to doxorubicin via the PI3K/AKT/mTOR signaling pathway.
Authors: Li Z, Qian J, Li J, Zhu C Abstract The resistance to chemotherapeutic drugs is a critical feature of breast cancer recurrence and metastasis. Long non-coding RNAs (LncRNAs) serve key roles in tumor drug resistance. LncRNA-HOX transcript antisense RNA (HOTAIR) has been reported to be overexpressed in certain types of cancer and may be closely associated with tumor resistance. The current study aimed to investigate the role of lncRNA-HOTAIR in the regulation of breast cancer resistance to doxorubicin (DOX). A breast cancer cell line (MCF-7) and DOX-resistant breast cancer cell line (DOXR-MCF-7) were utilized...
Source: Experimental and Therapeutic Medicine - July 10, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

PCAT1 is a poor prognostic factor in endometrial carcinoma and associated with cancer cell proliferation, migration and invasion.
In this study, we used 89 EC tissues and HEC-1B, Ishikawa, RL95-2 and AN3CA EC cell lines. We found elevated expression levels of PCAT1 in EC tissues and cell lines using reverse transcription qPCR (RT-qPCR). The prognostic value of PCAT1 was determined using Kaplan-Meier survival and Cox regression analysis. The results showed that higher PCAT1 expression was positively correlated with FIGO stage, myometrial invasion, lymph node metastasis, and a shorter overall survival. A series of functional assays showed that the knockdown of PCAT1 by small interfering RNA (siRNA) targeting PCAT1 (siPCAT1) suppressed cell proliferatio...
Source: Bosnian Journal of Basic Medical Sciences - May 29, 2019 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

Effect of dihydroarteminin combined with siRNA targeting Notch1 on Notch1/c-Myc signaling in T-cell lymphoma cells.
Authors: Huo L, Wei W, Wu S, Zhao X, Zhao C, Zhao H, Sun L Abstract The effectiveness of therapy combining dihydroartemisinin (DHA) and small interfering RNA targeting Notch1 (siNotch1) in T-cell lymphoma remains unknown. The present study explored the potential and possible mechanisms of combined dihydroarteminin, and siNotch1 therapy for T-cell lymphoma. It was demonstrated that the viability rates of siRNA-DHA-treated cells was significantly suppressed in comparison with those in control cells, control siRNA cells, siRNA-treated cells and DHA-treated cells (P<0.01). Additionally, there was a significant incre...
Source: Experimental and Therapeutic Medicine - March 31, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effect of taurine on the proliferation and apoptosis of human hepatocellular carcinoma HepG2 cells.
Authors: Tu S, Zhang X, Luo D, Liu Z, Yang X, Wan H, Yu L, Li H, Wan F Abstract The aim of the present study was to observe the effect and molecular mechanism of taurine (Tau) on the cell proliferation and apoptosis of human hepatocellular carcinoma (HHCC) HepG2 cells. HHCC HepG2 cells were used as target cells, and the cell survival rate was assessed using a multi-time-step method. The p53 upregulated modulator of apoptosis (PUMA) gene was transiently transfected by lipofection and subsequently silenced with specific small interfering (si)RNA. The cell apoptosis rate was detected by flow cytometry, and protein exp...
Source: Experimental and Therapeutic Medicine - November 18, 2015 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Histone deacetylase 6 activity is critical for the metastasis of Burkitt’s lymphoma cells
Conclusions: We identified a critical role of HDAC6 in the metastasis of Burkitt?s lymphoma cells, suggesting that pharmacological inhibition of HDAC6 could be a promising strategy for the management of metastatic Burkitt?s lymphoma.
Source: BioMed Central - December 5, 2014 Category: Journals (General) Authors: Ning DingLingyan PingLixia FengXiaohui ZhengYuqin SongJun Zhu Source Type: research