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Specialty: Cytology
Cancer: Cervical Cancer
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Total 20 results found since Jan 2013.
Matrix metalloproteinase-2 delivery to extracellular vesicles produced by HPV-positive cervical cancer cells enhances metastasis via the Akt pathway
Cell Biol Int. 2023 Jun 5. doi: 10.1002/cbin.12054. Online ahead of print.ABSTRACTHere, we aimed to analyze the effects of matrix metalloproteinase-2 (MMP-2) delivery to extracellular vesicles (EVs) secreted by human papillomavirus (HPV)-associated cervical cancer cells on human umbilical vein endothelial cell (HUVEC) angiogenesis. First, MMP-2 expression was compared among SiHa (HPV16), HeLa (HPV18), and C-33A (negative) cells. Then, EVs were isolated from these cells, and MMP-2 expression in the EVs was compared. SiHa and HeLa cells were transfected with MMP-2 or control siRNA. HUVECs were treated with EVs isolating from...
Source: Cell Biology International - June 5, 2023 Category: Cytology Authors: Jianan Sun Junjun Mou Yunmei Zhang Kang Yuan Ying Yang Qing Tang Source Type: research
HPV E6 promotes cell proliferation of cervical cancer cell by accelerating accumulation of RBM15 dependently of autophagy inhibition
This study explored the role of methyltransferase components in HPV-related cervical cancer and the mechanism. The levels of methyltransferase components and autophagy, ubiquitylation of RBM15 protein and the co-localization of lysosomal markers LAMP2A and RBM15 were measured. CCK-8 assay, flow cytometry, clone formation experiment and immunofluorescence assay were conducted to measure cell proliferation. The mouse tumor model was developed to study the cell growth in vivo. The binding of RBM15 to c-myc mRNA and m6A modifcation of c-myc mRNA were analyzed. The expressions of METTL3, RBM15 and WTAP were higher in HPV-positi...
Source: Cell Biology International - May 16, 2023 Category: Cytology Authors: Gang Nie Bo Tang Mingfen Lv Danyang Li Tian Li Rongying Ou Yunsheng Xu Juan Wen Source Type: research
LncRNA LINC00649 aggravates the progression of cervical cancer through sponging miR-216a-3p
CONCLUSIONS: The LINC00649 expression may act as a prognostic predictor and may aggravate cervical cancer progression by targeting miR-216a-3p, providing potential therapeutic targets for patients with cervical cancer.PMID:36054700 | DOI:10.1111/jog.15405
Source: Cell Research - September 2, 2022 Category: Cytology Authors: Congying Si Lanlan Yang Xu Cai Source Type: research
CD73 promotes cervical cancer growth via EGFR/AKT1 pathway
CONCLUSIONS: Our data demonstrated that CD73 overexpression promote cervical cancer growth in vitro and in vivo, via activating EGFR/AKT1 pathway.PMID:35706815 | PMC:PMC9189233 | DOI:10.21037/tcr-21-2446
Source: Cell Research - June 16, 2022 Category: Cytology Authors: Chong Liu Zhao-Wei Gao Xi Wang Fang Lin Hui-Zhong Zhang Ke Dong Source Type: research
Study on the effect and mechanism of NFKBIA on cervical cancer progress in vitro and in vivo
CONCLUSION: By inhibiting β-catenin-mediated transcription, NFKBIA functioning as a tumor suppressor might be introduced as a novel anti-metastatic agent for the treatment of targeted CC.PMID:34342105 | DOI:10.1111/jog.14947
Source: Cell Research - August 3, 2021 Category: Cytology Authors: Mengyue Chen Xiaolong Liang Zhiqing Liang Limei Zhao Source Type: research
Novel small molecule inhibitor of Kpn β1 induces cell cycle arrest and apoptosis in cancer cells
This study investigated the effect of a novel small molecule, Inhibitor of Nuclear Import-60 (INI-60), on cancer cell biology, as well as nuclear import activities associated with Kpnβ1, and cancer progression in vivo using cervical and oesophageal cancer cell lines. INI-60 treatment resulted in the inhibition of cancer cell proliferation, colony formation, migration and invasion, and induced a G1/S cell cycle arrest, followed by cancer cell death via apoptosis. Non-cancer cells were minimally affected by INI-60 at concentrations that inhibited cancer cells. INI-60 treatment altered the localisation of Kpnβ1 and its carg...
Source: Experimental Cell Research - May 21, 2021 Category: Cytology Authors: Aderonke Ajayi-Smith Pauline van der Watt Nonkululeko Mkwanazi Sarah Carden John O Trent Virna D Leaner Source Type: research
