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67PPARP inhibition enhances cisplatin sensitivity in cervical cancer by modulating β-catenin signaling
ConclusionsOur data provides experimental evidence on the contribution of PARP-1 inhibition in enhancing the cytotoxicity of CDDP in cervical cancer cells. We also present novel findings on the suppression of β-catenin and its downstream signaling components by PARP-1 inhibitor. #: 5μM of CDDP was used both alone and in combination with PJ34; ##: A gradient of CDDP from 0-15μM was used to evaluate the combined effect of PJ34 and CDDP on IC50 value of CDDP. p: *<0.05, **<0.01. (H): HeLa; (S): SiHa.Legal entity responsible for the studyThe authors.FundingAll India Institute of Medical Sciences.DisclosureAll authors ...
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

An Ensemble Strategy to Predict Prognosis in Ovarian Cancer Based on Gene Modules
Conclusion Considering the heterogeneity and complexity of ovarian cancer, we demonstrated a new method to predict the prognosis of ovarian cancer based on the clustering information and gene co-expression network in each subtype of cancer patients. We divided the ovarian cancer data into three subtypes by clustering analysis and we found that the survival risks in these three subtypes were significantly different. We mined the important communities based on the co-expression networks in each subtype. There are 50, 73, and 92 communities in the first, second and third subtype, respectively. Next, we constructed a new ense...
Source: Frontiers in Genetics - April 23, 2019 Category: Genetics & Stem Cells Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Effect of Ku80 on the radiosensitization of cisplatin in the cervical carcinoma cell line HeLa.
Authors: Zhuang L, Liu F, Peng P, Xiong H, Qiu H, Fu X, Xiao Z, Huang X Abstract Cisplatin chemotherapy in combination with radiotherapy is the primary therapeutic strategy for the treatment of cervical cancer; however, the underlying molecular mechanism for cisplatin radiosensitization remains unknown. The aim of the present study was to investigate the effect of Ku80, a DNA double-strand break (DSB) repair protein, on cisplatin radiosensitization in cervical cancer. The pre-established Ku80 suppression cervical cancer cell line HeLa/Ku80-siRNA and the normal HeLa cell line underwent 6 MV X-ray irradiation (6 Gy) ...
Source: Oncology Letters - January 31, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Silencing of fused toes homolog enhances cisplatin sensitivity in cervical cancer cells by inhibiting epidermal growth factor receptor-mediated repair of DNA damage
ConclusionFTS is involved in EGFR-mediated repair of DNA damage induced by cisplatin in ME180 cells. This suggests that FTS can be a target to increase the efficacy of cisplatin in cervical cancer cells that exhibit increased nuclear phosphorylated EGFR in response to cisplatin.
Source: Cancer Chemotherapy and Pharmacology - August 16, 2016 Category: Cancer & Oncology Source Type: research

Abstract 5097: APE1/Ref-1 promotes cell adhesion and migration in cervical cancer cells
In this study, we are the first to report that APE1/Ref-1 activates cell adhesion-related proteins to trigger cell migration. To investigate whether APE1/Ref-1 is involved in cell adhesion in normal fibroblasts, an adhesion assay was performed using GM00637 human fibroblast cell lines stably overexpressing APE1/Ref-1. Cell adhesion to vitronectin, a known ligand of the adhesion molecules integrin ανβ3 and integrin ανβ5, was significantly increased in APE1/Ref-1-overexpressing GM00637 cells compared to control fibroblast cells. FACS analysis showed APE1/Ref-1 induces the expression and activation of adhesion molecules...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Kim, M., You, H. J., Kim, D. J. Tags: Tumor Biology Source Type: research

FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells
Conclusion EGFR and FTS physically associate with each other and FTS silencing radiosensitizes ME180 cells through impaired nuclear EGFR signaling.
Source: Journal of Cancer Research and Clinical Oncology - January 15, 2015 Category: Cancer & Oncology Source Type: research