Filtered By:
Specialty: Drugs & Pharmacology
Cancer: Gastric (Stomach) Cancer
This page shows you your search results in order of date.
Order by Relevance | Date
Total 47 results found since Jan 2013.
Raltitrexed regulates proliferation and apoptosis of HGC-27 cells by upregulating RSK4
CONCLUSION: Our study shows that RSK4 is a key target of raltitrexed in the regulation of gastric cancer cell proliferation, cell cycle progression, and apoptosis.PMID:36031631 | DOI:10.1186/s40360-022-00605-2
Source: BMC Pharmacology and Toxicology - August 28, 2022 Category: Drugs & Pharmacology Authors: Cong Hu Xinhua Chen Xu Lin Jun Dai Jiang Yu Source Type: research
Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways
CONCLUSION: Flotillin-1 might be used as a molecular marker for GC diagnosis and could be explored as a potential new target for the treatment of GC.PMID:34774850 | DOI:10.1016/j.ejphar.2021.174631
Source: European Journal of Pharmacology - November 14, 2021 Category: Drugs & Pharmacology Authors: Jiahui Wei Ruiqing Wang Yiran Lu Song He Bao Yuan Jiabao Zhang Yu Ding Source Type: research
Helichrysetin inhibits gastric cancer growth by targeting c-Myc/PDHK1 axis-mediated energy metabolism reprogramming
Acta Pharmacol Sin. 2021 Aug 30. doi: 10.1038/s41401-021-00750-0. Online ahead of print.ABSTRACTHelichrysetin (HEL), a chalcone isolated from Alpinia katsumadai Hayata, has an antitumor activity in human lung and cervical cancers. However, the inhibitory effect and underlying mechanism of HEL in gastric cancer have not been elucidated. Here, HEL significantly inhibited the growth of gastric cancer MGC803 cells in vitro and in vivo. HEL decreased expression and transcriptional regulatory activity of c-Myc and mRNA expression of c-Myc target genes. HEL enhanced mitochondrial oxidative phosphorylation (OXPHOS) and reduced gly...
Source: Acta Pharmacologica Sinica - August 31, 2021 Category: Drugs & Pharmacology Authors: Ping Wang Jin-Mei Jin Xiao-Hui Liang Ming-Zhu Yu Chun Yang Fei Huang Hui Wu Bei-Bei Zhang Xiao-Yan Fei Zheng-Tao Wang Ren Xu Hai-Lian Shi Xiao-Jun Wu Source Type: research
Cinnamaldehyde induces autophagy-mediated cell death through ER stress and epigenetic modification in gastric cancer cells
Acta Pharmacol Sin. 2021 May 12. doi: 10.1038/s41401-021-00672-x. Online ahead of print.ABSTRACTPrevious reports suggested that cinnamaldehyde (CA), the bioactive ingredient in Cinnamomum cassia, can suppress tumor growth, migratory, and invasive abilities. However, the role and molecular mechanisms of CA in GC are not completely understood. In the present study, we found that CA-induced ER stress and cell death via the PERK-CHOP axis and Ca2+ release in GC cells. Inhibition of ER stress using specific-siRNA blocked CA-induced cell death. Interestingly, CA treatment resulted in autophagic cell death by inducing Beclin-1, A...
Source: Acta Pharmacologica Sinica - May 13, 2021 Category: Drugs & Pharmacology Authors: Tae Woo Kim Source Type: research
Boswellic acid sensitizes gastric cancer cells to Cisplatin-induced apoptosis via p53-mediated pathway.
CONCLUSIONS: Altogether, our findings suggest that AKBA enhances GC cell sensitivity to CDDP-induced apoptosis via the p53 pathway.
PMID: 32867831 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - September 2, 2020 Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Keratin 18 (KRT18) induces proliferation, migration, and invasion in gastric cancer via the MAPK signaling pathway.
CONCLUSIONS: KRT18 plays a cancer-promoting role and might be a potential therapeutic target in the treatment of GC.
PMID: 32860257 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - August 27, 2020 Category: Drugs & Pharmacology Authors: Wang PB, Chen Y, Ding GR, Du HW, Fan HY Tags: Clin Exp Pharmacol Physiol Source Type: research
Values of long noncoding RNA SAMMSON in the clinicopathologic features and the prognostic implications of human gastric cancer.
CONCLUSIONS: LncRNA-SAMMSON played an important role in the development of GC, which might be regarded as a new target for the diagnosis and treatment of GC.
PMID: 32572923 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 25, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
