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Total 26674 results found since Jan 2013.

Novel siRNA therapeutics demonstrate multi-variant efficacy against SARS-CoV-2
Antiviral Res. 2023 Jul 19:105677. doi: 10.1016/j.antiviral.2023.105677. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a respiratory virus that causes COVID-19 disease, with an estimated global mortality of approximately 2%. While global response strategies, which are predominantly reliant on regular vaccinations, have shifted from zero COVID to living with COVID, there is a distinct lack of broad-spectrum direct acting antiviral therapies that maintain efficacy across evolving SARS-CoV-2 variants of concern. This is of most concern for immunocompromised and immunosuppressed ...
Source: Antiviral Research - July 21, 2023 Category: Virology Authors: Ellen Bowden-Reid Scott Ledger Yuan Zhang Francesca Di Giallonardo Anupriya Aggarwal Alberto Ospina Stella Anouschka Akerman Vanessa Milogiannakis Gregory Walker William Rawlinson Stuart Turville Anthony D Kelleher Chantelle Ahlenstiel Source Type: research

A siRNA targets and inhibits a broad range of SARS-CoV-2 infections including Delta variant
EMBO Mol Med. 2022 Feb 8:e15298. doi: 10.15252/emmm.202115298. Online ahead of print.ABSTRACTThe emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants has altered the trajectory of the COVID-19 pandemic and raised some uncertainty on long term efficiency of vaccine strategy. The development of new therapeutics against a wide range of SARS-CoV-2 variants is imperative. We here have designed an inhalable siRNA, C6G25S, which covers 99.8% of current SARS-CoV-2 variants and is capable of inhibiting dominant strains, including Alpha, Delta, Gamma and Epsilon, at picomolar ranges of IC50 in vitro. Mo...
Source: Molecular Medicine - February 9, 2022 Category: Molecular Biology Authors: Yi-Chung Chang Chi-Fan Yang Yi-Fen Chen Chia-Chun Yang Yuan-Lin Chou Hung-Wen Chou Tein-Yao Chang Tai-Ling Chao Shu-Chen Hsu Si-Man Ieong Ya-Min Tsai Ping-Cheng Liu Yuan-Fan Chin Jun-Tung Fang Han-Chieh Kao Hsuan-Ying Lu Jia-Yu Chang Ren-Shiuan Weng Qian- Source Type: research

Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis
CONCLUSIONS: This review identifies many of the factors that influence a person's decision to take part in a vaccine trial, and these reflect findings from reviews that examine trials more broadly. However, we also recognise some factors that become more important in connection with a vaccine trial in the context of a pandemic or epidemic. These factors include the potential stigma of taking part, the possible adverse effects of a vaccine, the added motivation for helping society, the role of community leaders in trial dissemination, and the level of trust placed in governments and companies developing vaccines. These spec...
Source: Cochrane Database of Systematic Reviews - September 1, 2023 Category: General Medicine Authors: Pauline Meskell Linda M Biesty Maura Dowling Kevin Roche Elaine Meehan Claire Glenton Declan Devane Sasha Shepperd Andrew Booth Rebecca Cox Xin Hui S Chan Catherine Houghton Source Type: research

Threads Blocks Search Results For ' COVID ' And ' Vaccines ' , Upsetting Users
Threads Blocks Search Results For 'COVID' And 'Vaccines', Upsetting Users Authored by Bryan Jung via The Epoch Times, Threads, Meta's recent competitor to Twitter, is facing harsh criticism for blocking search results for terms related to the pandemic, including vaccines. The new text platform,…#bryanjung #epochtimes #threads #meta #twitter #threadsusersshocked #michaelrobertson #xmeta #misinfo #namesotherplatforms
Source: Reuters: Health - September 14, 2023 Category: Consumer Health News Source Type: news

New Research Provides Hope In The Search For A Respiratory Syncytial Virus Vaccine- Part III
While the search for a vaccine for respiratory syncytial virus has eluded scientists and vaccine manufacturers for decades, it looks as if there may be a vaccine in the foreseeable future, within the next few years.
Source: Forbes.com Healthcare News - May 10, 2022 Category: Pharmaceuticals Authors: William A. Haseltine, Contributor Tags: Healthcare /healthcare Innovation /innovation Coronavirus business pharma & Source Type: news

Viruses, Vol. 15, Pages 1065: Intra-Host Co-Existing Strains of SARS-CoV-2 Reference Genome Uncovered by Exhaustive Computational Search
In this study, we present a computational method aimed at identifying co-existing intra-host strains of the virus from RNA-sequencing data of short reads that were used to assemble the original reference genome. Our method consisted of five key steps: extraction of relevant reads, error correction for the reads, identification of within-host diversity, phylogenetic study, and protein binding affinity analysis. Our study revealed that multiple strains of SARS-CoV-2 can coexist in both the viral sample used to produce the reference sequence and a wastewater sample from California. Additionally, our workflow demonstrated its ...
Source: Viruses - April 26, 2023 Category: Virology Authors: Xinhui Cai Tian Lan Pengyao Ping Brian Oliver Jinyan Li Tags: Article Source Type: research

Genes, Vol. 13, Pages 2147: Anticipating the Next Chess Move: Blocking SARS-CoV-2 Replication and Simultaneously Disarming Viral Escape Mechanisms
Assumpção The COVID-19 pandemic initiated a race to determine the best measures to control the disease and to save as many people as possible. Efforts to implement social distancing, the use of masks, and massive vaccination programs turned out to be essential in reducing the devastating effects of the pandemic. Nevertheless, the high mutation rates of SARS-CoV-2 challenge the vaccination strategy and maintain the threat of new outbreaks due to the risk of infection surges and even lethal variations able to resist the effects of vaccines and upset the balance. Most of the new therapies tested against SARS-CoV-2 came ...
Source: Genes - November 18, 2022 Category: Genetics & Stem Cells Authors: Samir Mansour Moraes Casseb Andr é Salim Khayat Jorge Estefano Santana de Souza Edivaldo Herculano Correa de Oliveira Sidney Emanuel Batista Dos Santos Pedro Fernando da Costa Vasconcelos Paulo Pimentel de Assump ção Tags: Article Source Type: research

Abstracts of Presentations at the Association of Clinical Scientists 143 < sup > rd < /sup > Meeting Louisville, KY May 11-14,2022
Conclusion: These assays are suitable for routine diagnostic. The UltraFast NextGenPCR is the fastest with average time (30mins), followed by Agilent (2 hrs) and MassArray (6hrs). Upon completion of this activity, participants should be able to examine, measure and compare results from different assays for SARS detection, evaluate and diagnose accurately, as well as being able to plan, organize and recommend a diagnostic procedure for diagnostic laboratory. Key words: SARS-CoV-2, RNA extraction, RT-PCR, limit of detection, quantification cycle, COVID-19, in vitro diagnostic tests, Agilent, Massarray, Ultrafast. [20] From t...
Source: Annals of Clinical and Laboratory Science - July 1, 2022 Category: Laboratory Medicine Source Type: research