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Diagnosis and therapy of granulomatosis with polyangiitis and microscopic polyangiitis-2023: consensus of the Austrian society of nephrology ( ÖGN) and Austrian society of rheumatology (ÖGR)
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):656-674. doi: 10.1007/s00508-023-02262-9. Epub 2023 Sep 20.ABSTRACTANCA-associated vasculitides (AAV) are rare, complex systemic diseases that are often difficult to diagnose, because of unspecific clinical symptoms at presentation. However, the clinical course may be very dramatic and even life-threatening, necessitating prompt diagnosis and treatment.Therefore, it is important to increase disease awareness among physicians and support colleagues who are not confronted with these rare diseases on a regular basis. Here, the Austrian Society of Nephrology (ÖGN) and the Austrian S...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Balazs Odler Martin Windpessl Kathrin Eller Marcus D S äemann Karl Lhotta Irmgard Neumann Gregor Öberseder Christina Duftner Christian Dejaco Michael Rudnicki Philipp Gauckler Rainer Hintenberger Jochen Zwerina Jens Thiel Andreas Kronbichler Source Type: research
Diagnosis and therapy of membranous nephropathy-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):648-655. doi: 10.1007/s00508-023-02261-w. Epub 2023 Sep 20.ABSTRACTMembranous nephropathy (MN) is an immune-complex glomerulonephritis and is one of the most common causes of nephrotic syndrome in adults and is also one of the autoimmune kidney diseases with the highest rate of spontaneous remission. The most common autoantigen (> 70% of cases) is directed against the phospholipase A2 receptor (PLA2-R) and, with its detection and clinical course, allows for excellent diagnostics as well as optimal therapy monitoring. Other autoantigens are constantly being published and will e...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Marcus D S äemann Balazs Odler Martin Windpessl Heinz Regele Kathrin Eller Irmgard Neumann Michael Rudnicki Philipp Gauckler Andreas Kronbichler Maarten Knechtelsdorfer Source Type: research
Diagnosis and treatment of focal-segmental glomerulosclerosis-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):638-647. doi: 10.1007/s00508-023-02260-x. Epub 2023 Sep 20.ABSTRACTThe histopathological term focal-segmental glomerulosclerosis comprises different pathogenic processes with the unifying features of a high proteinuria and the name-giving glomerular lesion pattern seen on light microscopy. A differentiation according to the underlying cause into primary, secondary and genetic forms is therefore of utmost importance. The pathogenesis of primary focal-segmental glomerulosclerosis remains unknown but, like minimal-change disease, an autoimmune-mediated process leading to podocyte da...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Philipp Gauckler Emanuel Zitt Heinz Regele Kathrin Eller Marcus D S äemann Karl Lhotta Irmgard Neumann Michael Rudnicki Balazs Odler Andreas Kronbichler Johannes Zschocke Martin Windpessl Source Type: research
Diagnosis and treatment of Minimal Change Disease in adults-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):628-637. doi: 10.1007/s00508-023-02258-5. Epub 2023 Sep 20.ABSTRACTMinimal change disease is a glomerulopathy that clinically manifests as acute onset nephrotic syndrome. A diagnosis is made by renal biopsy, implying the absence of glomerular lesions on light microscopy but detection of extensive podocyte foot process effacement on electron miscroscopy. Considering the typically excellent response to immunosuppressive measures (especially to glucocorticoids), an autoimmune pathogenesis is assumed. Although general prognosis is overall beneficial, steroid-dependent, steroid-resist...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Philipp Gauckler Heinz Regele Kathrin Eller Marcus D S äemann Karl Lhotta Emanuel Zitt Irmgard Neumann Michael Rudnicki Balazs Odler Andreas Kronbichler Martin Windpessl Source Type: research
Diagnosis and Treatment of IgA Nephropathy-2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):621-627. doi: 10.1007/s00508-023-02257-6. Epub 2023 Sep 20.ABSTRACTImmunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis. It leads to end-stage kidney disease in about a third of the patients within 10 to 20 years. The pathogenesis of IgAN is incompletely understood. It is believed that a dysregulation of the mucosal immune system leads to undergalactosylation of IgA, followed by formation of IgG autoantibodies against undergalactosylated IgA, circulation of these IgG-IgA immune complexes, deposition of the immune complexes in the mesangium, ultimately resulti...
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Judith Schimpf Andreas Kronbichler Martin Windpessl Emanuel Zitt Kathrin Eller Marcus D S äemann Karl Lhotta Michael Rudnicki Source Type: research
Consensus recommendations for the diagnosis and therapy of glomerulonephritides of the Austrian Society of Nephrology ( ÖGN) - 2023
Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):619-620. doi: 10.1007/s00508-023-02259-4. Epub 2023 Sep 20.NO ABSTRACTPMID:37728646 | DOI:10.1007/s00508-023-02259-4
Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Andreas Kronbichler Marcus D S äemann Source Type: research
Physical activity and physical fitness among children and adolescents after the onset of the COVID-19 pandemic in the WHO European Region: a systematic review protocol
Introduction
The implementation of COVID-19 pandemic-related restrictions resulted in limitations for physical activity (PA) opportunities, which may have initiated a longer-term behavioural change. The protocol describes the methodology for a planned systematic review that aims to summarise changes in PA and physical fitness (PF) in children and adolescents in the WHO European Region after the onset of the COVID-19 pandemic.
Methods and analysis
The protocol adheres to the ‘Preferred Reporting Items for Systematic Review and Meta-Analysis for Protocols’ (PRISMA-P) statement. Using a peer-reviewed search strat...
Source: BMJ Open - September 20, 2023 Category: General Medicine Authors: Ludwig-Walz, H., Siemens, W., Heinisch, S., Dannheim, I., Loss, J., Bujard, M. Tags: Open access, Sports and exercise medicine, COVID-19 Source Type: research
Incidence of vasa praevia: a systematic review and meta-analysis
Conclusion
The incidence of VP in unselected pregnancies is 1 in 1218 pregnancies. This is higher than is previously reported and can be used as a basis to assess whether screening for this condition should be part of routine clinical practice. Incorporation of strategies to screen for VP in routine clinical practice is likely to prevent 5% of stillbirths.
PROSPERO registration number
CRD42020125495.
Source: BMJ Open - September 20, 2023 Category: General Medicine Authors: Zhang, W., Giacchino, T., Chanyarungrojn, P. A., Ionescu, O., Akolekar, R. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
Exploring experiences of times without care and encounters in dementia: protocol for a living and adaptive evidence map
Introduction
Individuals with dementia spend most of the day without care, without encounters, and usually without activity. Although this has been proven in studies, there is a knowledge gap on how individuals with dementia experience these periods of time. Such knowledge would be highly relevant for health professionals and relatives to develop adequate strategies for dealing with these periods of time. The FreiZeit study aims to reconstruct periods of time without care and encounters from the perspective of individuals with dementia and formal and informal carers. The specific objective of this review is to provide a co...
Source: BMJ Open - September 20, 2023 Category: General Medicine Authors: Hirt, J., Adlbrecht, L., Maurer, C., Beer, T. Tags: Open access, Public health Source Type: research
Resilience perspective on healthcare professionals adaptations to changes and challenges resulting from the COVID-19 pandemic: a meta-synthesis
Conclusion
Healthcare professionals demonstrated significant adaptive capacity when faced with challenges imposed by the COVID-19 pandemic. Several adaptations were identified as beneficial for future organisational healthcare service changes, while others exposed weaknesses in healthcare system designs and capacity, leading to dysfunctional adaptations. Healthcare professionals’ experiences working during the COVID-19 pandemic present a unique opportunity to learn how healthcare systems rapidly respond to changes, and how resilient healthcare services can be built globally.
Source: BMJ Open - September 20, 2023 Category: General Medicine Authors: Knutsen Glette, M., Ludlow, K., Wiig, S., Bates, D. W., Austin, E. E. Tags: Open access, Health services research, COVID-19 Source Type: research
Central retinal vein and artery occlusion associated with sildenafil: a case report and review of the literature
ConclusionSildenafil may be associated with severe retinal vascular accidents in otherwise healthy young individuals.
Source: Journal of Medical Case Reports - September 20, 2023 Category: General Medicine Source Type: research
Emergency Department waiting-time in the post pandemic era: new organizational models, a challenge for the future
CONCLUSIONS: data show an increase in the time spent in the EDs and an increase in the overcrowding, according to the NEDOCS index. New management models and a reorganization of EDs are needed as the workload has increased significantly.PMID:37724561 | DOI:10.23750/abm.v94iS3.14262
Source: Acta Bio-Medica : Atenei Parmensis - September 19, 2023 Category: General Medicine Authors: Giuseppe Stirparo Erika Kacerik Aida Andreassi Paolo Pausilli Francesca Cortellaro Anna Coppo Maurizio Migliari Andrea Albonico Giuseppe Maria Sechi Alberto Zoli Carlo Signorelli Source Type: research
Eg észségügyi szakmai irányelv – A thrombotikus thrombocytopeniás purpura (TTP) és a haemolytikus uraemiás syndroma (HUS) kezeléséről
Orv Hetil. 2022 Sep 19;164(Supplement-1):3-59. doi: 10.1556/650.2023.32878. Print 2022 Sep 19.NO ABSTRACTPMID:37725506 | DOI:10.1556/650.2023.32878
Source: Orvosi Hetilap - September 19, 2023 Category: General Medicine Authors: Eg észségügyi Szakmai Kollégium Source Type: research
Silicone hydrogel versus hydrogel soft contact lenses for differences in patient-reported eye comfort and safety
CONCLUSIONS: The overall evidence for a difference between all included silicone hydrogel and hydrogel SCLs was of very low certainty, with most trials at high overall risk of bias. The majority of studies did not assess comfort using a validated instrument. There was insufficient evidence to support recommending one SCL material over the other. For extended wear, hydrogel SCL may have a lower risk of adverse events at 52 weeks compared to silicon hydrogel. Future well-designed trials are needed to generate high certainty evidence to further clarify differences in SCL material comfort and safety.PMID:37724689 | PMC:PMC1050...
Source: Cochrane Database of Systematic Reviews - September 19, 2023 Category: General Medicine Authors: Kristina Haworth Darian Travis Louis Leslie Daniel Fuller Andrew D Pucker Source Type: research
A comparison of chronic conditions and health characteristics between cancer survivors and non-cancer survivors
DISCUSSION: These findings can be used by healthcare and public health practitioners to evaluate the programmatic efforts and resources, implement targeted interventions toward cancer survivors, and improve health and quality of life.PMID:37724026 | DOI:10.1177/17423953231180191
Source: Chronic Illness - September 19, 2023 Category: General Medicine Authors: Anjin Singh Michael Shayne Gallaway Addey Rascon Source Type: research
