Diagnosis and treatment of Minimal Change Disease in adults-2023

Wien Klin Wochenschr. 2023 Aug;135(Suppl 5):628-637. doi: 10.1007/s00508-023-02258-5. Epub 2023 Sep 20.ABSTRACTMinimal change disease is a glomerulopathy that clinically manifests as acute onset nephrotic syndrome. A diagnosis is made by renal biopsy, implying the absence of glomerular lesions on light microscopy but detection of extensive podocyte foot process effacement on electron miscroscopy. Considering the typically excellent response to immunosuppressive measures (especially to glucocorticoids), an autoimmune pathogenesis is assumed. Although general prognosis is overall beneficial, steroid-dependent, steroid-resistant and frequently-relapsing disease courses may complicate the management of these patients and necessitate the use of alternative immunosuppressive treatment strategies. Here, the Austrian Society of Nephrology (ÖGN) provides a consensus on how to best diagnose and manage adult patients with minimal change disease.PMID:37728648 | PMC:PMC10511370 | DOI:10.1007/s00508-023-02258-5

Source: Wiener Klinische Wochenschrift - September 20, 2023 Category: General Medicine Authors: Philipp Gauckler Heinz Regele Kathrin Eller Marcus D S äemann Karl Lhotta Emanuel Zitt Irmgard Neumann Michael Rudnicki Balazs Odler Andreas Kronbichler Martin Windpessl Source Type: research