Filtered By:
Therapy: Corticosteroid Therapy

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 18794 results found since Jan 2013.

Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma
Asthma is a chronic inflammatory disease. Despite the fact that current therapies, such as the combination of inhaled corticosteroids and β2‐agonists, can control the symptoms of asthma in most patients, there is still an urgent need for an alternative anti‐inflammatory therapy for patients who suffer from severe asthma but lack acceptable response to conventional therapies. Many molecular factors are involved in the inflammatory process in asthma, and thus blocking the function of these factors could efficiently alleviate airway inflammation. RNA interference (RNAi) is often thought to be the answer in the search for...
Source: Archiv der Pharmazie - July 1, 2015 Category: Drugs & Pharmacology Authors: Yuran Xie, Olivia M. Merkel Tags: Minireview Source Type: research

B-cell receptor-guided delivery of peptide-siRNA complex for B-cell lymphoma therapy
Conclusions: Peptide-siRNA complex can be suitable tool for both selective peptide-driven cell targeting and gene silencing. In this setting, the improvement of this strategy is expected to provide a safe and non-invasive approach for the delivery of therapeutic molecules.
Source: Cancer Cell International - May 7, 2015 Category: Cancer & Oncology Authors: Nunzia MigliaccioCamillo PalmieriImmacolata RuggieroGiuseppe FiumeNicola MartucciIris ScalaIleana QuintoGiuseppe ScalaAnnalisa LambertiPaolo Arcari Source Type: research

Oligonucleotides —A Novel Promising Therapeutic Option for IBD
Conclusions In this review, we focused on recent and past approaches to test the therapeutic efficacy of oligonucleotide based therapies in IBD. The combining mechanistic mode of oligonucleotide based therapeutics is a targeted action on specific pro-inflammatory molecules, which are over activated in IBD patients and contribute significantly to disease pathogenesis. The proposed high selectivity of the agents is derived from its mode of action, that aims to specifically block certain inflammatory molecular patterns, without a general systemic effect on other molecular targets. It would be important for each oligonucleot...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model
In an established steroid-associated osteonecrosis (SAON) rabbit model we found recently that blockage Src by siRNA could improve reconstructive repair of osteonecrosis via enhancing osteogenesis and inhibiting bone resorption. The current study investigated if blocking Src was able to prevent steroid-associated osteoporosis (SAOP) in the same SAON animal model. Rabbits were treated with pulsed lipopolysaccharide (LPS) and corticosteroid methylprednisolone (MPS). At 2, 4, 6weeks after induction, Src siRNA, control siRNA and saline were intramedullary injected into proximal femur, respectively.
Source: Bone - November 17, 2015 Category: Orthopaedics Authors: Li-Zhen Zheng, Xin-Luan Wang, Hui-Juan Cao, Shi-Hui Chen, Le Huang, Ling Qin Tags: Original Full Length Article Source Type: research

Systemic corticosteroids for radicular and non-radicular low back pain
CONCLUSIONS: Systemic corticosteroids appear to be slightly effective at improving short-term pain and function in people with radicular low back pain not due to spinal stenosis, and might slightly improve long-term function. The effects of systemic corticosteroids in people with non-radicular low back pain are unclear and systemic corticosteroids are probably ineffective for spinal stenosis. A single dose or short course of systemic corticosteroids for low back pain does not appear to cause serious harms, but evidence is limited.PMID:36269125 | PMC:PMC9585990 | DOI:10.1002/14651858.CD012450.pub2
Source: Cochrane Database of Systematic Reviews - October 21, 2022 Category: General Medicine Authors: Roger Chou Rafael Zambelli Pinto Rongwei Fu Robert A Lowe Nicholas Henschke James H McAuley Tracy Dana Source Type: research

Inhaled corticosteroids versus placebo   for stable chronic obstructive pulmonary disease
CONCLUSIONS: This systematic review updates the evidence base for ICS monotherapy with newly published trials to aid the ongoing assessment of their role for people with COPD. Use of ICS alone for COPD likely results in a reduction of exacerbation rates of clinical relevance, probably results in a reduction in the rate of decline of FEV1 of uncertain clinical relevance and likely results in a small improvement in health-related quality of life not meeting the threshold for a minimally clinically important difference. These potential benefits should be weighed up against adverse events (likely to increase local oropharyngea...
Source: Cochrane Database of Systematic Reviews - March 27, 2023 Category: General Medicine Authors: Ian A Yang Olivia R Ferry Melissa S Clarke Esther Ha Sim Kwun M Fong Source Type: research

Red flags to screen for vertebral fracture in people presenting with low back pain
CONCLUSIONS: The available evidence suggests that only a few red flags are potentially useful in guiding clinical decisions to further investigate people suspected to have a vertebral fracture. Most red flags were not useful as screening tools to identify vertebral fracture in people with low back pain. In primary care, 'older age' was informative for 'unspecified vertebral fracture', and 'trauma' and 'corticosteroid use' were both informative for 'unspecified vertebral fracture' and 'osteoporotic vertebral fracture'. In secondary care, 'older age' was informative for 'osteoporotic vertebral fracture' and 'trauma' was info...
Source: Cochrane Database of Systematic Reviews - August 24, 2023 Category: General Medicine Authors: Christopher S Han Mark J Hancock Aron Downie Jeffrey G Jarvik Bart W Koes Gustavo C Machado Arianne P Verhagen Christopher M Williams Qiuzhe Chen Christopher G Maher Source Type: research

Systemic corticosteroids for radicular and non-radicular low back pain
CONCLUSIONS: Systemic corticosteroids appear to be slightly effective at improving short-term pain and function in people with radicular low back pain not due to spinal stenosis, and might slightly improve long-term function. The effects of systemic corticosteroids in people with non-radicular low back pain are unclear and systemic corticosteroids are probably ineffective for spinal stenosis. A single dose or short course of systemic corticosteroids for low back pain does not appear to cause serious harms, but evidence is limited.PMID:36269125 | DOI:10.1002/14651858.CD012450.pub2
Source: Cochrane Database of Systematic Reviews - October 21, 2022 Category: General Medicine Authors: Roger Chou Rafael Zambelli Pinto Rongwei Fu Robert A Lowe Nicholas Henschke James H McAuley Tracy Dana Source Type: research

Inhaled corticosteroids versus placebo   for stable chronic obstructive pulmonary disease
CONCLUSIONS: This systematic review updates the evidence base for ICS monotherapy with newly published trials to aid the ongoing assessment of their role for people with COPD. Use of ICS alone for COPD likely results in a reduction of exacerbation rates of clinical relevance, probably results in a reduction in the rate of decline of FEV1 of uncertain clinical relevance and likely results in a small improvement in health-related quality of life not meeting the threshold for a minimally clinically important difference. These potential benefits should be weighed up against adverse events (likely to increase local oropharyngea...
Source: Cochrane Database of Systematic Reviews - March 27, 2023 Category: General Medicine Authors: Ian A Yang Olivia R Ferry Melissa S Clarke Esther Ha Sim Kwun M Fong Source Type: research

Blood Biomarkers for Traumatic Brain Injury: A Quantitative Assessment of Diagnostic and Prognostic Accuracy
Conclusion We have reviewed the literature and identified blood biomarkers with the highest discriminative abilities as determined by operating characteristics in four commonly encountered clinical situations: diagnosing concussion, predicting the need for a CT scan after mTBI, predicting delayed recovery after mTBI, and predicting poor outcome after sTBI. The top performers in each category may provide insight into pathogenic mechanisms of TBI that most influence the measured endpoint. Nonetheless, many challenges remain before these biomarkers can be incorporated into clinical practice. In particular, it remains unclear...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Topical corticosteroids for treating phimosis in boys.
CONCLUSIONS: Topical corticosteroids offer an effective alternative for treating phimosis in boys. Although sub optimal reporting among the included studies meant that the size of the effect remains uncertain, corticosteroids appear to be a safe, less invasive first-line treatment option before undertaking surgery to correct phimosis in boys. PMID: 25180668 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - September 2, 2014 Category: Journals (General) Authors: Moreno G, Corbalán J, Peñaloza B, Pantoja T Tags: Cochrane Database Syst Rev Source Type: research

Corticosteroid therapy for nephrotic syndrome in children.
CONCLUSIONS: In this 2015 update the addition of three well-designed studies has changed the conclusion of this review. Studies of long versus shorter duration of corticosteroids have heterogeneous treatment effects, with the older high risk of bias studies tending to over-estimate the effect of longer course therapy, compared with more recently published low risk of bias studies. Among studies at low risk of bias, there was no significant difference in the risk for FRNS between prednisone given for two or three months and longer durations or total dose of therapy indicating that there is no benefit of increasing the durat...
Source: Cochrane Database of Systematic Reviews - March 18, 2015 Category: Journals (General) Authors: Hahn D, Hodson EM, Willis NS, Craig JC Tags: Cochrane Database Syst Rev Source Type: research