Blood Biomarkers for Traumatic Brain Injury: A Quantitative Assessment of Diagnostic and Prognostic Accuracy

Conclusion We have reviewed the literature and identified blood biomarkers with the highest discriminative abilities as determined by operating characteristics in four commonly encountered clinical situations: diagnosing concussion, predicting the need for a CT scan after mTBI, predicting delayed recovery after mTBI, and predicting poor outcome after sTBI. The top performers in each category may provide insight into pathogenic mechanisms of TBI that most influence the measured endpoint. Nonetheless, many challenges remain before these biomarkers can be incorporated into clinical practice. In particular, it remains unclear whether a large panel of biomarkers in addition to clinical assessment will be sufficient to first stratify patients into categories of TBI before more specific biomarker assessments are applied. Alternatively, in the age of precision medicine, biomarker assessment may be tailored to individual patients. Ideally, pre-clinical development will help refine approaches for clinical application. Author Contributions ZG, SG, LG, DM, and SS contributed to the acquisition, analysis, and interpretation of the data. SS, RS, and DS contributed to study conception and design. ZG, RS, and SS drafted the work, and all other authors (SG, LG, DM, DS) revised it critically for important intellectual content. All authors (ZG, SS, RS, SG, LG, DM, DS) provide approval for publication of the content and agree to be accountable for all aspects of the work in ensuring that ques...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Publication date: Available online 20 November 2019Source: Journal of Advanced ResearchAuthor(s): Sohail Mumtaz, Pradeep Bhartiya, Neha Kaushik, Manish Adhikari, Pradeep Lamichhane, Su-Jae Lee, Nagendra Kumar Kaushik, Eun Ha ChoiAbstractOver the past few decades, microwave (MW) radiation has been widely used, and its biological effects have been extensively investigated. However, the effect of MW radiation on human skin biology is not well understood. We study the effects of pulsed high-power microwaves (HPMs) on melanoma (G361 and SK-Mel-31) and normal human dermal fibroblast (NHDF) cells. A pulsed power generator (Chundo...
Source: Journal of Advanced Research - Category: Research Source Type: research
Resting state functional connectivity (RSFC) has been widely studied in functional magnetic resonance imaging (fMRI) and is observed by a significant temporal correlation of spontaneous low-frequency signal fluctuations (SLFs) both within and across hemispheres during rest. Different hypotheses of RSFC include the biophysical origin hypothesis and cognitive origin hypothesis, which show that the role of SLFs and RSFC is still not completely understood. Furthermore, RSFC and age studies have shown an “age-related compensation” phenomenon. RSFC data analysis methods include time domain analysis, seed-based correl...
Source: Neuroimaging Clinics - Category: Radiology Authors: Source Type: research
ConclusionLL/MLD4, MLA, MLD, the degree of luminal diameter stenosis, CCO, RI, and %APV derived from cCTA can support the detection of hemodynamically significant coronary stenosis as compared with iFR®, with LL/MLD4 showing the greatest discriminatory power.
Source: European Journal of Radiology - Category: Radiology Source Type: research
The objective of this study was to assess the clinical and radiographic outcomes of surgical management in a multicentre cohort of paediatric patients with burst fractures, in order to devise an optimal therapeutic strategy.HypothesisA therapeutic strategy for burst fractures in children and adolescents can be devised based on data from a patient cohort and on previously published information.Material and methodsPatients younger than 18 years who were managed surgically for one or more burst fractures (Magerl A3) were included in this retrospective multicentre study. Clinical, radiographic, and surgical data were collected...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
We read with great interest the published case report titled, “Cerebrospinal fluid leak after coccyx fracture.” The report showed very impressive magnetic resonance imaging and computerized tomography (CT) images demonstrating apparent leakage of cerebrospinal fluid after a traumatic fall [1].
Source: The Spine Journal - Category: Orthopaedics Authors: Tags: Letters to the editor Source Type: research
We are pleased to invite investors and analysts to participate in a live audio webcast and conference call on Monday, 16 December 2019, highlighting Roche data presented at the San Antonio Breast Cancer Symposium in San Antonio, Texas, from 10th - 14th December.
Source: Roche Investor Update - Category: Pharmaceuticals Source Type: news
Journal of Medicinal Food, Ahead of Print.
Source: Journal of Medicinal Food - Category: Nutrition Authors: Source Type: research
Artificial intelligence is already widely entrenched in healthcare industry, so the question should not be, "Will AI happen or not?" said David Houlding, CISSP, CIPP, principal healthcare lead, at Microsoft, in an interview with MD+DI. “It's very much 'What tasks will AI help with, and what will it do and what will it not do?’ ” he continued. “I think we're still learning some of that, but it's largely a proven technology, not just for healthcare providers but for payers, for pharmaceuticals, for life sciencesâ&#...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
CONCLUSIONS Our data demonstrate an oncogenic role of miR-652 in uveal melanoma, showing that miR-652 may be a useful biomarker for prediction of prognosis for patients with uveal melanoma. PMID: 31740654 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The nude mouse orthotopic liver transplantation model of human HCC was shown to be a reliable model that has the potential for future research on the pathogenesis and progression of HCC and studies on drug development. PMID: 31736477 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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