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Nutrition: Antidoxidants

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Modeling Modulation of the Tick Regulome in Response to Anaplasma phagocytophilum for the Identification of New Control Targets
Conclusion Our modeling of the modulation of the tick regulome in response to A. phagocytophilum infection provided new insights into the mechanisms that target specific functions in different tick tissues. These results supported the use of network analysis for the study of regulome response to infection. Although general mechanisms affected by A. phagocytophilum infection may be conserved even between tick and human cells (de la Fuente et al., 2016b), the effect of vector-pathogen co-evolution on pathogen isolates adaptation to grow in tick cells (Alberdi et al., 2015) may result in differences between isolates in the m...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

Auranofin, an Anti-rheumatic Gold Drug, Aggravates the Radiation-Induced Acute Intestinal Injury in Mice
Conclusion In this study, we found that a non-toxic dose of auranofin significantly aggravated the severity of the radiation-induced intestinal injury. This suggests that auranofin treatment can be an independent factor that influences the risk of intestinal complications after pelvic or abdominal radiotherapy. Ethics Statement All the protocols used in this study were approved by the Institutional Animal Care and Use Committee of the Korean Institute of Radiological and Medical Sciences (IACUC permit number: KIRAMS217-0007). Author Contributions H-JL, JS, and Y-BL designed the experiments. EL and JK conducted the exp...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Homologous-targeting biomimetic nanoparticles for photothermal therapy and Nrf2-siRNA amplified photodynamic therapy against oral tongue squamous cell carcinoma
Publication date: 15 May 2020Source: Chemical Engineering Journal, Volume 388Author(s): Shurui Shi, Yue Wang, Beibei Wang, Qian Chen, Guoyun Wan, Xiaoying Yang, Juan Zhang, Lianyun Zhang, Changyi Li, Yinsong WangAbstractPhotothermal therapy (PTT) and photodynamic therapy (PDT) have some advantages such as site selectivity, non- or little-invasive property and negligible drug resistance for treatment of oral tongue squamous cell carcinoma (OTSCC). However, the activation of intracellular antioxidant responses will partly counteract anticancer effects of PDT. As a well-known redox-regulated transcription factor, Nrf2 has bee...
Source: Chemical Engineering Journal - February 5, 2020 Category: Chemistry Source Type: research

Lipid nanoparticle delivery of siRNA targeting < em > Cyp2e1 < /em > gene attenuates subacute alcoholic liver injury in mice
CONCLUSIONS: The si-Cyp2e1 LNP may attenuate subacute alcoholic liver injury in mice mainly by reducing reactive oxygen levels, increasing antioxidant activity, blocking oxidative stress pathways and reducing ethanol-induced steatosis and inflammation.PMID:37476942 | DOI:10.3724/zdxbyxb-2022-0729
Source: Cancer Control - July 21, 2023 Category: Cancer & Oncology Authors: Shuang Wu Qiubing Chen Yalan Wang Hao Yin Yuan Wei Source Type: research

The Effect of Nutritional Interventions Reducing Oxidative Stress on Behavioral and Gastrointestinal Problems in Autism Spectrum Disorder
CONCLUSION: Most studies on the interventions of nutritional supplements that reduce oxidative stress in individuals with ASD have found improving effects on ASD symptoms, and no serious side effects have been observed. However, more interventional studies are needed to determine the precise effects of oxidative stress-reducing nutritional supplementation.PMID:36843243 | DOI:10.1002/jdn.10254
Source: International Journal of Developmental Neuroscience - February 27, 2023 Category: Neuroscience Authors: Hatice Çolak Esra Tansu Sar ıyer Nalan Hakime No ğay Source Type: research

The effect of nutritional interventions reducing oxidative stress on behavioural and gastrointestinal problems in autism spectrum disorder
CONCLUSION: Most studies on the interventions of nutritional supplements that reduce oxidative stress in individuals with ASD have found improving effects on ASD symptoms, and no serious side effects have been observed. However, more interventional studies are needed to determine the precise effects of oxidative stress-reducing nutritional supplementation.PMID:36843243 | DOI:10.1002/jdn.10254
Source: International Journal of Developmental Neuroscience - February 27, 2023 Category: Neuroscience Authors: Hatice Colak Esra Tansu Sariyer Nalan Hakime Nogay Source Type: research