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Infectious Disease: Pandemics
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Total 8434 results found since Jan 2013.
Where Art Thou O treatment for diabetic neuropathy: the sequel
This article challenges the rationale for the FDA insisting on symptoms/signs and nerve conduction as primary endpoints for clinical trials in DPN.EXPERT OPINION: Quantitative sensory testing, intraepidermal nerve fiber density, and especially corneal confocal microscopy remain an after-thought, demoted at best to exploratory secondary endpoints in clinical trials of diabetic neuropathy. If pharma are to be given a fighting chance to secure approval for a new therapy for diabetic neuropathy, the FDA needs to reassess the evidence rather than rely on 'opinion' for the most suitable endpoint(s) in clinical trials of diabetic...
Source: Expert Review of Neurotherapeutics - August 21, 2023 Category: Neurology Authors: Yigit Can Guldiken Ayesha Malik Ioannis N Petropoulos Hoda Gad Einas Elgassim Iuliia Salivon Georgios Ponirakis Uazman Alam Rayaz A Malik Source Type: research
The role of the gut microbiome and microbial metabolism in mediating opioid-induced changes in the epigenome
The current opioid pandemic is a major public health crisis in the United States, affecting millions of people and imposing significant health and socioeconomic burdens. Preclinical and clinical research over the past few decades has delineated certain molecular mechanisms and identified various genetic, epigenetic, and environmental factors responsible for the pathophysiology and comorbidities associated with opioid use. Opioid use-induced epigenetic modifications have been identified as one of the important factors that mediate genetic changes in brain regions that control reward and drug-seeking behavior and are also im...
Source: Frontiers in Microbiology - August 21, 2023 Category: Microbiology Source Type: research
Changes in opioid prescribing in veterans with headache during the COVID-19 pandemic: A regression discontinuity in time analysis
CONCLUSION: Prescription opioid access was maintained for veterans within VHA during the pandemic. The de-escalation of opioid prescribing observed prior to the pandemic was not seen in our study.PMID:37596904 | DOI:10.1111/head.14605
Source: Headache - August 19, 2023 Category: Neurology Authors: Kaicheng Wang Brenda T Fenton Melissa Skanderson Anne C Black William C Becker Elizabeth K Seng Sarah E Anthony Alexander B Guirguis Hamada H Altalib Addison Kimber Nancy Lorenze Joel D Scholten Glenn D Graham Friedhelm Sandbrink Jason J Sico Source Type: research
Animal Welfare Noncompliance: Data and Process
Brent C. Morse, DVM, DACLAM, Director, OLAW Division of Compliance Oversight Office of Extramural Research, NIH
As part of proper stewardship of taxpayer funds, we at NIH are obligated, both legally and ethically, to ensure the welfare and reduce risks for those involved in our supported research activities. This obligation includes research animals. Their humane care and use is something we take very seriously. We appreciate that Congress, the research community, interest groups, and other members of the public look towards us to observe this commitment. Today we are taking some time to touch upon our policies to protec...
Source: NIH Extramural Nexus - August 17, 2023 Category: Research Authors: Mike Lauer Tags: blog Open Mike Animal Welfare Grants policy Source Type: funding
We Can Prevent Overdose Deaths If We Change How We Think About Them
I’ve been living in recovery from opioid use disorder for eight and a half years, and this might be a weird thing to say about addiction, but I feel lucky—like I dodged a bullet. I was addicted to opioids in Florida throughout the early 2000s, during the heyday of pill mills that flooded the streets with powerful pharmaceuticals like OxyContin. I say I’m lucky because this was just before the drug supply turned into a toxic sludge of potent fentanyl analogues, mysterious tranquilizers, and deadly counterfeit pills. Sometimes I wonder what it would be like if I were using today. The chances of my survival ...
Source: TIME: Health - August 15, 2023 Category: Consumer Health News Authors: Ryan Hampton Tags: Uncategorized freelance Source Type: news
A new study finds that telehealth is effective in treating neck and back pain.
Patients presenting with neck and back pain during the pandemic were studied. Study results show that telehealth is effective in treating and selecting patients for procedures. LOS ANGELES, Aug. 14, 2023 /PRNewswire-PRWeb/ -- A new study just published in the journal Interventional Pain...
Source: PRWeb: Medical Pharmaceuticals - August 14, 2023 Category: Pharmaceuticals Tags: SVY Source Type: news
The use of complementary and alternative medicine for the treatment of gastrointestinal symptoms in Long COVID: a systematic review
CONCLUSION: This is the first systematic review to explore the role of CAM in treating GI manifestations of Long COVID. The review identified four studies, all reporting reductions in the GI symptoms of Long COVID. Despite the positive studies included in this review, the overall search yielded few results, all of which were non-experimental. As the post-infectious sequelae of COVID-19 become better recognized in the wake of the pandemic, higher-quality clinical studies are needed.PMID:37577106 | PMC:PMC10422885 | DOI:10.1177/20406223231190548
Source: Adv Data - August 14, 2023 Category: Epidemiology Authors: Brent Gawey Juan Yang Brent Bauer Joanne Song Xiao Jing Wang Source Type: research
Bonus Features – August 13, 2023 – 75% of executives thing generative AI has reached the point where it will reshape healthcare, 64% of patients would trust AI over a doctor to make a diagnosis, and more,
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
The Drug Enforcement Administration will hold listening sessions Sept. 12 and 13 to discuss allowing a “special registration” to allow physicians to remotely prescribe certain controlled substances without the ...
Source: EMR and HIPAA - August 13, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT American Telemedicine Association Ana Sirbu AssureCare ATA ATA Nexus Azure Bain CitiusTech DEA DrFirst eClinicalWorks eCW Epic Generative AI Healthcare Generative AI Healthcare IT Today Bonus Features health Source Type: blogs
Telerehabilitation is as effective as outpatient visits in the management of early osteoarthritis knee and mechanical low backache
ConclusionTeleconsultation is equally effective to that as face-to-face outpatient consultation in the rehabilitation of patients with early OA knee and mechanical LBA.Level of studyLevel 2, Prospective comparative study.
Source: European Journal of Orthopaedic Surgery and Traumatology - August 11, 2023 Category: Orthopaedics Source Type: research
COVID-19 ’ s Impact on Heart Health Still Confounds Doctors
(ST. LOUIS) — Firefighter and paramedic Mike Camilleri once had no trouble hauling heavy gear up ladders. Now battling long COVID, he gingerly steps onto a treadmill to learn how his heart handles a simple walk.
“This is, like, not a tough-guy test so don’t fake it,” warned Beth Hughes, a physical therapist at Washington University in St. Louis.
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Somehow, a mild case of COVID-19 set off a chain reaction that eventually left Camilleri with dangerous blood pressure spikes, a heartbeat that raced with slight exertion, and episodes of intense chest pain...
Source: TIME: Health - August 10, 2023 Category: Consumer Health News Authors: Lauran Needgaard/ Associated Press Tags: Uncategorized COVID-19 healthscienceclimate wire Source Type: news
Change in U.S. Hospice Quality Measure Scores During the COVID-19 Pandemic and Correlation With Exposure to State Policies for Protection of Older Adults
CONCLUSION: Most HIS scores increased during this COVID-19 pandemic period; there was a small, significant negative correlation between the composite quality score and exposure to state policies for older adult protection. Further research is needed to better understand the effects of the COVID-19 pandemic on hospice care in the U.S. and globally, and future additions in quality reporting may facilitate real-time assessment during future public health emergencies.PMID:37563122 | DOI:10.1177/10499091231194726
Source: The American Journal of Hospice and Palliative Care - August 10, 2023 Category: Palliative Care Authors: Janna Baker Rogers John Cagle Source Type: research
