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The Dengue Dance?
Discussion Dengue is an important arboviral infection that affects about 40% of the world population. It is found mainly in topical and subtropical areas of the world mainly in developing countries but it range is spreading including the United States. A review of common arboviruses can be found here. It is a flaviavirus with 4 distinct serotypes named DENV-1 through DENV-4 and is spread by A. aegypti a day biting mosquito. Infection with one serotype confers immunity to that serotype but not the others. It does offer some protection for cross-infection but this only lasts a few months. Incubation period is 3-14 days with ...
Source: PediatricEducation.org - July 29, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Advances Towards Painless Vaccination and Newer Modes of Vaccine Delivery
AbstractVaccines have been successful in reducing the mortality and morbidity, but most of them are delivered by intramuscular or intravenous route. They are associated with pain to the baby and bring lot of anxiety for the parents. There has been a marked increase in the number of injections required in first two years of life for completing the vaccination schedule. Hence, there is a need to have a painless vaccine delivery system. Numerous new routes of vaccination like, oral, nasal and transdermal routes are being tried. Oral polio and intranasal influenza have already been a success. Other newer approaches like edible...
Source: Indian Journal of Pediatrics - June 16, 2017 Category: Pediatrics Source Type: research

Extensive swelling reaction after a pentavalent vaccination.
Abstract Injection site reactions (ISRs) are quite common side effects defined by a local adverse drug reaction directly caused by a vaccine. Twenty-four hours after an intramuscular injection (in the deltoid muscle) of the diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, Haemophilus influenza type b (DTPCa-Hib) combined vaccine, a 3-year-old boy developed fever. A few hours later, local redness and swelling appeared at the injection site, with rapid extension to the entire limb, it was pain-free, and no other clinical anomalies were present. The patient received intravenous antibiotics for sus...
Source: Archives de Pediatrie - July 31, 2015 Category: Pediatrics Authors: Gébus M, Barbier C, Bost-Bru C, Michard-Lenoir AP, Plantaz D Tags: Arch Pediatr Source Type: research

The Good Thing About the Disney Measles Outbreak
Cases of measles linked to an exposure at Disneyland continue to spread, not just in California, but in several other states and in Mexico. The numbers of cases are climbing — and so are the number of exposed people who might get sick — and expose more people before they realize they are sick. Measles is extremely contagious; if someone has it, they will infect 90 percent of the people around them who aren’t immunized. It’s scary, because measles can be dangerous. 1 in 20 people who get it will get pneumonia. 1 in 1,000 will get encephalitis, a brain inflammation that can lead to seizures and brain ...
Source: Thrive, Children's Hospital Boston - February 10, 2015 Category: Pediatrics Authors: Claire McCarthy Tags: Claire McCarthy, MD Vaccines Source Type: news

Oral sucrose administration to reduce pain response during immunization in 16–19-month infants: a randomized, placebo-controlled trial
Conclusion: Sucrose solution reduces infant distress and is safe and clinically useful even for 16–19-month-old infants.
Source: European Journal of Pediatrics - October 11, 2014 Category: Pediatrics Source Type: research

What Causes Neck Stiffness?
Discussion The complaint of neck stiffness always makes the clinician a little concerned until he/she understands the whole history because of the potential diagnosis of meningitis/encephalitis. While this potential is always concerning, there are many other causes of neck stiffness or pain to consider that are much more common. Normal wear and tear, injury or overuse that occur in daily activities and work can cause neck stiffness or pain. Often, even in adults, the cause of the pain is not recognized. Good examples are the adolescent above, or an innocent stumble, particularly if carrying something that may cause a perso...
Source: PediatricEducation.org - June 30, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Haemophilus influenzae Type b in an Immunocompetent, Fully Vaccinated ALL Survivor
A 7-year-old boy with a history of recurrent acute lymphoblastic leukemia (ALL), in remission, presented to primary care clinic after 2 days of progressive right hip pain with weight-bearing activities. He was otherwise asymptomatic at the time of presentation. Blood cultures revealed Gram-negative diplococci, which prompted an MRI that was significant for a hip joint effusion and femoral head bone marrow edema. The patient had no sick contacts and no significant past medical history other than ALL. The patient had been given all recommended childhood vaccinations. Arthrocentesis and needle biopsy of the femoral neck were ...
Source: PEDIATRICS - May 1, 2013 Category: Pediatrics Authors: Nevin, J., Kanter Washko, J., Arnold, J. Tags: Case Report Source Type: research