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Procedure: Heart Transplant

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Total 58 results found since Jan 2013.

Transplantation Trends in End Stage Hypertrophic Cardiomyopathy Over 35 Years: A UNOS Registry Analysis
Hypertrophic cardiomyopathy (HCM) is a rare but potentially life-threatening form of hereditary myopathy with increasing incidence. Therapies are emerging for HCM but the incidence of end-stage HCM has been increasing. We sought to describe the incidence and outcomes of HCM transplantation over the last 35 years.
Source: The Journal of Heart and Lung Transplantation - April 1, 2023 Category: Transplant Surgery Authors: D.J. Miklin, E. DePasquale Tags: (527) Source Type: research

Heart transplantation for COVID-19 myopathy in the United States
Evidence on characteristics and outcomes of patients undergoing heart transplantation for coronavirus disease 2019 (COVID-19) associated cardiomyopathy is limited to case reports. Of all 6332 patients aged ≥18 years undergoing heart transplant from July 2020 through May 2022 in the United Network for Organ Sharing database, 12 (0.2%) patients had COVID-19 myocarditis and 98 (1.6%) patients with the same level of care had non-COVID-19 myocarditis. Their median age was 49 (range 19-74) years. All pati ents were hospitalized in the intensive care unit and 92.7% (n=102) were on life support prior to transplantation.
Source: The Journal of Heart and Lung Transplantation - October 5, 2022 Category: Transplant Surgery Authors: George Gill, Amy Roach, Georgina Rowe, Dominic Emerson, Jon Kobashigawa, Errol P. Lobo, Fardad Esmailian, Michael E. Bowdish, Joanna Chikwe Tags: Brief Communication Source Type: research

Early cardiac rehabilitation after heart transplantation in a patient with limb-girdle muscular dystrophy: A case report
Rationale: Cardiac rehabilitation (CR) after heart transplantation (HT) decreases the mortality rate and increases exercise capacity of patients. Dilated cardiomyopathy develops in most patients with muscular dystrophy (MD), leading to advanced heart failure, necessitating the use of left ventricular assist devices or HT. As the clinical outcomes of left ventricular assist devices and HT in patients with myopathy differ from those in patients without myopathy, CR adapted to patients with MD should be considered. Patient concerns: A 39-year-old man with limb-girdle muscular dystrophy developed dilated cardiomyopa...
Source: Medicine - July 29, 2022 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Amyloid myopathy: expanding the clinical spectrum of transthyretin amyloidosis —case report and literature review
AbstractWe identified two patients with transthyretin (ATTR) amyloid myopathy (one ATTR variant amyloidosis, ATTRv; one wild-type ATTR amyloidosis, ATTRwt). Myopathy was the initial manifestation in ATTRwt, whereas it followed neuropathy and cardiomyopathy in ATTRv. The ATTRwt patient showed muscular tracer uptake on99mTc-DPD planar scintigraphy at the time of initial diagnosis, consistent with ATTR amyloid myopathy. The ATTRv patient underwent heart transplantation because of progressive heart failure. Within the next two years, progressive myopathic symptoms and extracardiac tracer uptake on99mTc-DPD planar scintigraphy ...
Source: Journal of Nuclear Cardiology - May 17, 2022 Category: Nuclear Medicine Source Type: research

Major Adverse Dystrophinopathy Event Score as Marker of Cumulative Morbidity and Risk for Mortality in Boys with Duchenne Muscular Dystrophy
Accurate assessments of heart failure (HF) severity in Duchenne Muscular Dystrophy (DMD) is challenging due to overlapping symptoms from cardiomyopathy, respiratory insufficiency, and skeletal myopathy. We developed an ordinal scale of multiorgan clinical variables and events graded for severity that reflect cumulative disease burden-the Major Adverse Dystrophinopathy Event (MADE) score. We hypothesized that a higher MADE score would be associated with increased mortality in DMD. We used the CINRG Duchenne Natural History Study (DNHS) dataset for MADE score validation.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: B.D. Kaufman, A. Garcia, Z. He, M. Buu, C. Tesi-Rocha, J.W. Day, D.N. Rosenthal, H. Gordish-Dressman, C. Almond, T. Duong Tags: (200) Source Type: research

Successful Heart Transplantation in a Patient with Neonatal Marfan Syndrome
We describe a case of a teenage girl with NMS who developed inotrope-dependent heart failure secondary to dilated cardiomyopathy requiring heart transplantation.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: S. Hussain, G. Geddes, R. Darragh, J.J. Parent Tags: (1285) Source Type: research

A Comparison of Short-Term Morbidity and Mortality Among Inpatient Lung Transplant Recipients Transplanted for COVID-19 and Other Restrictive Lung Diseases
Patients with respiratory failure (RF) who are hospitalized at the time of lung transplant (LTx) have higher post-LTx morbidity and mortality than those who are well enough to remain at home. Complications may be even worse in patients transplanted for COVID-19 (C19), as they are commonly critically ill having endured prolonged mechanical ventilation, ECMO support, myopathy, malnutrition, and superimposed infections. In a retrospective cohort study, we compared inpatient lung transplant recipients (LTxRs) transplanted for C19 vs.
Source: The Journal of Heart and Lung Transplantation - April 1, 2022 Category: Transplant Surgery Authors: D. Razia, M.T. Olson, R. Walia, R.M. Bremner, M.A. Smith, S. Tokman Tags: (289) Source Type: research

A Novel SPEG mutation causing congenital myopathy with fiber size disproportion and dilated cardiomyopathy with heart transplantation
In this report, we describe two Brazilian siblings, aged 13 and 6 years, with a novel homozygous mutation (c.8872 C>T:p.Arg2958Ter) in the SPEG gene leading to a congenital myopathy. In the older sibling, the muscle biopsy showed fiber size disproportion.
Source: Neuromuscular Disorders - September 21, 2021 Category: Neurology Authors: Juliana Gurgel-Giannetti, Lucas Santos Souza, Guilherme Ferraz Messina de P ádua Andrade, Maria de Fátima Derlene, Zilda Maria Alves Meira, Beatriz Vilela Morais Azevedo, Wilson Campos Jr, Sabrina Stephanie Lana Diniz, Marina Belisario Carvalhais, Julia Tags: Case report Source Type: research

Mild form of Danon disease: two case reports
Danon disease (OMIM: 300257) is an X-linked dominant lysosomal storage disease characterized by the triad of cardiomyopathy, myopathy, and mental retardation [1]. The causative gene is lysosome-associated membrane protein-2 (LAMP-2), which plays an important role in autophagosome-lysosome fusion in autophagy [2]. Typically, cardiomyopathy is remarkably severe in male patients, requiring heart transplantation; otherwise, it is lethal by their mid-twenties [1,3,4]. We herein report two unrelated male patients showing mild manifestations of Danon disease.
Source: Neuromuscular Disorders - August 2, 2021 Category: Neurology Authors: Toshio Yasui, Utako Nagaoka, Yasushi Oya, Akinori Uruha, Jun Karashima, Asuka Funai, Kazuhito Miyamoto, Shiro Matsubara, Keizo Sugaya, Kazushi Takahashi, Michio Inoue, Mariko Okubo, Kazuma Sugie, Ichizo Nishino Tags: Case report Source Type: research

Favorable Outcomes after Heart Transplantation in Barth Syndrome
Barth Syndrome (BTHS) is a rare, X-linked disease characterized by cardioskeletal myopathy and neutropenia. Comparative outcomes after heart transplantation have not been reported.
Source: The Journal of Heart and Lung Transplantation - July 10, 2021 Category: Transplant Surgery Authors: Yu Li, Justin Godown, Carolyn L. Taylor, Anne I. Dipchand, Valerie M. Bowen, Brian Feingold Tags: Original Clinical Science Source Type: research

Prevalence and clinical outcomes of dystrophin ‐associated dilated cardiomyopathy without severe skeletal myopathy
ConclusionsDMD-associated DCM without severe skeletal myopathy is characterized by incomplete penetrance but high risk of MACE, including progression to end-stage heart failure and ventricular arrhythmias. DCM onset is the major determinant of prognosis with similar survival regardless of the presence of skeletal myopathy.
Source: European Journal of Heart Failure - June 9, 2021 Category: Cardiology Authors: Maria A. Restrepo ‐Cordoba, Karim Wahbi, Anca R. Florian, Juan Jiménez‐Jáimez, Luisa Politano, Michael Arad, Vicente Climent‐Paya, Ana Garcia‐Alvarez, Rasmus B. Hansen, José M. Larrañaga‐Moreira, Milos Kubanek, Luis R. Lopes, And Tags: Research Article Source Type: research

Immediate Post-Discharge Comprehensive Rehabilitation Program Expedites Heart Transplant Recovery and Reduces Readmission
Recovery of strength and endurance post heart transplant (HTx) has remained relatively slow. Factors that limit early rehabilitation include sternotomy precautions and corticosteroid myopathy. We propose that specialized, comprehensive rehabilitation program (COLTT) can be initiated immediately after discharge to (1) improve functional outcomes (2) decrease hospital readmission.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: J. Chapa, C. DiPerna, P. Lueck, L. Tucker, C. Hage, M. Guglin, M. Jones, K. Ballut, R. Rao Tags: (627) Source Type: research

Cardiac Transplantation in Danon Disease
Danon disease is a rare X-linked dominant cardioskeletal myopathy caused by mutations in the lysosome-associated membrane protein-2 (LAMP-2) gene. Currently, there are no disease modifying therapies for Danon disease. The purpose of this study is to characterize individuals with Danon disease who undergo cardiac transplantation and describe their outcomes.
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: K.N. Hong, C. Battikha, A. Lin, S. John, M. Brambatti, A. Garcia-Alvarez, L. Garcia-Guereta, C. Diez, L. Perez-Gomez, P. Garcia-Pavia, M. Taylor, E. Adler Tags: (666) Source Type: research

Severe Myopathy Following Heart Transplantation in a Patient with Danon Disease
A patient with Danon disease develops a severe myopathy with rhabdomyolysis following heart transplantation (HT).
Source: The Journal of Heart and Lung Transplantation - March 20, 2021 Category: Transplant Surgery Authors: J. Guzman Bofarull, L. Castrillo, J. Milisenda, A. Garc ía Álvarez, M. Castel, E. Sandoval, T. López Sobrino, M. Farrero, F. Pérez-Villa Tags: (1236) Source Type: research