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Performance of the 2017 European Alliance of Associations for Rheumatology/American College of Rheumatology Classification Criteria in Patients With Idiopathic Inflammatory Myopathy and Anti –Melanoma Differentiation–Associated Protein 5 Positivity
ConclusionIn this cohort of patients with anti –MDA-5–positive IIM, the diagnosis could not be classified by the EULAR/ACR criteria in almost 30% of patients. We suggest incorporating anti–MDA-5 antibody positivity as a criterion into existing criteria sets or developing specific criteria for patients with anti–MDA-5–positive IIM.
Source: Arthritis and Rheumatology - July 26, 2022 Category: Rheumatology Authors: Ho So, Jacqueline So, Tommy Tsz ‐On Lam, Victor Tak‐Lung Wong, Roy Ho, Wai Ling Li, Chi Chiu Mok, Chak Sing Lau, Lai‐Shan Tam Tags: Brief Report Source Type: research

Performance of the 2017 EULAR/ACR classification criteria in anti ‐MDA5 associated idiopathic inflammatory myopathy
ConclusionsAlmost 30% of patients with clinical anti-MDA5 associated IIM could not be classified by the EULAR/ACR criteria. Modification of the existing criteria incorporating anti-MDA5 antibody or development of a new specific set of criteria for “anti-MDA5 syndrome” are suggested.
Source: Arthritis and Rheumatology - April 25, 2022 Category: Rheumatology Authors: Ho So, Jacqueline So, Tommy Tsz ‐On Lam, Victor Tak‐Lung Wong, Roy Ho, Wai Ling Li, Chi Chiu Mok, Chak Sing Lau, Lai‐Shan Tam Tags: Brief Report Source Type: research

A common missense variant of LILRB5 is associated with statin intolerance and myalgia
ConclusionThis study presents a novel immunogenetic factor associated with statin intolerance, an important risk factor for cardiovascular outcomes. The results suggest that true statin-induced myalgia and non-specific myalgia are distinct, with a potential role for the immune system in their development. We identify a genetic group that is more likely to be intolerant to their statins.
Source: European Heart Journal - August 29, 2017 Category: Cardiology Source Type: research

Propofol as a Risk Factor for ICU-Acquired Weakness in Septic Patients with Acute Respiratory Failure.
CONCLUSIONS: Propofol exposure may increase the risk of ICUAW in septic patients. An interaction through sodium channel inactivation is hypothesized. PMID: 28091345 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - January 15, 2017 Category: Neurology Authors: Abdelmalik PA, Rakocevic G Tags: Can J Neurol Sci Source Type: research

Development and validation of algorithms for the detection of statin myopathy signals from electronic medical records.
This article is protected by copyright. All rights reserved. PMID: 27706800 [PubMed - as supplied by publisher]
Source: Clinical Pharmacology and Therapeutics - October 4, 2016 Category: Drugs & Pharmacology Authors: Chan SL, Tham MY, Tan SH, Loke C, Foo B, Fan Y, Ang PS, Brunham LR, Sung C Tags: Clin Pharmacol Ther Source Type: research

Graphic Mining of High ‐Order Drug Interactions and Their Directional Effects on Myopathy Using Electronic Medical Records
We propose to study a novel pharmacovigilance problem for mining directional effects of high ‐order drug interactions on an adverse drug event (ADE). Our goal is to estimate each individual risk of adding a new drug to an existing drug combination. In this proof‐of‐concept study, we analyzed a large electronic medical records database and extracted myopathy‐relevant case control dru g co‐occurrence data. We applied frequent itemset mining to discover frequent drug combinations within the extracted data, evaluated directional drug interactions related to these combinations, and identified directional drug interact...
Source: CPT: Pharmacometrics and Systems Pharmacology - August 25, 2015 Category: Drugs & Pharmacology Authors: L Du, A Chakraborty, C ‐W Chiang, L Cheng, SK Quinney, H Wu, P Zhang, L Li, L Shen Tags: Original Article Source Type: research

SLCO1B1 Polymorphisms and Statin-Induced Myopathy
Clinical scenario Statins are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors which reduce the risk of coronary events and death by lowering blood concentrations of low density lipoprotein cholesterol (LDL-c).1,2,3,4 They are generally regarded as safe and well tolerated. However, some patients experience adverse muscle symptoms; these are mostly relatively mild but, in rare cases, severe muscle damage with renal failure (rhabdomyolysis) may occur (reviewed in 5,6). Recently, an autoimmune form of necrotising myositis has also been identified as a rare statin-associated myopathy (reviewed in 7). There ...
Source: PLOS Currents Evidence on Genomic Tests - December 4, 2013 Category: Genetics & Stem Cells Authors: Alison Stewart Source Type: research

SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof of Concept Study Using the Clinical Practice Research Datalink (CPRD).
Abstract The study aimed to determine whether patients with statin-induced myopathy could be identified using the United Kingdom Clinical Practice Research Datalink (CPRD), DNA obtained, and thereby replicate previously reported associations of statin myopathy with the SLCO1B1 c.521T>C and COQ2 rs4693075 polymorphisms.Seventy seven statin-myopathy patients (serum CPK>4xULN) and 372 statin-tolerant controls were identified and recruited. Multiple logistic regression analysis showed SLCO1B1 c.521T>C SNP to be a significant risk factor (p=0.009) with an odds ratio per variant allele of 2.06 (1.32-3.15) for a...
Source: Clinical Pharmacology and Therapeutics - August 13, 2013 Category: Drugs & Pharmacology Authors: Carr DF, O'Meara H, Jorgensen AL, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M Tags: Clin Pharmacol Ther Source Type: research

Development of a detection algorithm for statin‐induced myopathy using electronic medical records
ConclusionWe report on a detection algorithm with high predictability for SIM using EMRs. Combined use of exclusion criteria for disease, medical practice data and time course of CK values contributes to better prediction of SIM. The utility of the proposed algorithm should be further confirmed in a larger study.
Source: Journal of Clinical Pharmacy and Therapeutics - March 26, 2013 Category: Drugs & Pharmacology Authors: K. Sai, T. Hanatani, Y. Azuma, K. Segawa, M. Tohkin, H. Omatsu, H. Makimoto, M. Hirai, Y. Saito Tags: Original Article Source Type: research