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Total 71 results found since Jan 2013.

Acceptability of Artificial Intelligence in Poultry Processing and Classification Efficiencies of Different Classification Models in the Categorisation of Breast Fillet Myopathies
Breast meat from modern fast-growing big birds is affected with myopathies such as woody breast (WB), white striping, and spaghetti meat (SM). The detection and separation of the myopathy-affected meat can be carried out at processing plants using technologies such as bioelectrical impedance analysis (BIA). However, BIA raw data from myopathy-affected breast meat are extremely complicated, especially because of the overlap of these myopathies in individual breast fillets and the human error associated with the assignment of fillet categories. Previous research has shown that traditional statistical techniques such as ANOVA...
Source: Frontiers in Physiology - September 22, 2021 Category: Physiology Source Type: research

Rosuvastatin and Colchicine combined myotoxicity: lessons to be learnt
AbstractStatins and colchicine co-administration consists of a potentially catastrophic drug –drug interaction since it provokes myotoxicity, myopathy and various degrees of rhabdomyolysis. Lipophilic statins and colchicine are biotransformed in the liver, primarily via CYP3A4 enzyme system leading to elevated blood levels of both agents and resulting in increased potential for combined m yotoxicity. Hence, it would be of great clinical importance not only the awareness of this devastating complication but also the more advantageous type of statin that we should choose to achieve the recommended therapeutic goals regardi...
Source: CEN Case Reports - May 24, 2021 Category: Urology & Nephrology Source Type: research

Identification of a novel MICU1 nonsense variant causes myopathy with extrapyramidal signs in an Iranian consanguineous family
ConclusionsOur finding along with previous studies provides more evidence on the clinical presentation of the disease caused by pathogenic mutations inMICU1. Finding more variants and expanding the spectrum of the disease increases the diagnostic rate of molecular testing in screening of this kind of diseases and in turn improves the quality of counseling for at risk couples and helps them to minimize the risks of having affected children.
Source: Molecular and Cellular Pediatrics - May 9, 2021 Category: Cytology Source Type: research

A machine learning-based clinical tool for diagnosing myopathy using multi-cohort microarray expression profiles
Myopathies are a heterogenous collection of disorders characterized by dysfunction of skeletal muscle. In practice, myopathies are frequently encountered by physicians and precise diagnosis remains a challenge...
Source: Journal of Translational Medicine - November 30, 2020 Category: Research Authors: Andrew Tran, Chris J. Walsh, Jane Batt, Claudia C. dos Santos and Pingzhao Hu Tags: Research Source Type: research

High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin.
CONCLUSION: These findings suggest that high dose simvastatin and rosuvastatin impair cognitive functions via decreasing BDNF, NGF and irisin levels in the hippocampus. PMID: 33010350 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - September 29, 2020 Category: Neurology Authors: Okudan N, Belviranli M Tags: Brain Res Bull Source Type: research

Sarcoidosis and the Nervous System
This article provides an overview and update on the neurologic manifestations of sarcoidosis. RECENT FINDINGS The 2018 Neurosarcoidosis Consortium diagnostic criteria emphasize that biopsy is key for diagnosis and determines the level of diagnostic certainty. Thus, definite neurosarcoidosis requires nervous system biopsy and probable neurosarcoidosis requires biopsy from extraneural tissue. Without biopsy, possible neurosarcoidosis can be diagnosed if the clinical, imaging, and laboratory picture is compatible and other causes are ruled out. Recent large retrospective studies from the United States and France establishe...
Source: CONTINUUM: Lifelong Learning in Neurology - June 1, 2020 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Evaluation via Supervised Machine Learning of the Broiler Pectoralis Major and Liver Transcriptome in Association With the Muscle Myopathy Wooden Breast
The muscle myopathy wooden breast (WB) has recently appeared in broiler production and has a negative impact on meat quality. WB is described as hard/firm consistency found within the pectoralis major (PM). In the present study, we use machine learning from our PM and liver transcriptome dataset to capture the complex relationships that are not typically revealed by traditional statistical methods. Gene expression data was evaluated between the PM and liver of birds with WB and those that were normal. Two separate machine learning algorithms were performed to analyze the data set including the sequential minimal optimizati...
Source: Frontiers in Physiology - February 24, 2020 Category: Physiology Source Type: research

What Causes Respiratory Failure?
Discussion The respiratory system is a complex system. The upper airways must remain patient. The lower airways must interface with the vascular system. The musculoskeletal system must provide mechanical function and the central nervous system must provide overall control. Respiratory failure occurs when the overall system cannot support the body’s necessarily ventilation, oxygenation or both. Children are at higher risk of respiratory failure. They have few intrinsic lung parenchyma problems, but have very small airways that increase the airflow resistance by themselves but then have to contend with problems such as...
Source: PediatricEducation.org - December 2, 2019 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Immune-Mediated Myopathies
This article summarizes the clinical features, diagnostic evaluation, and management of the common immune-mediated myopathies: dermatomyositis, antisynthetase syndrome, immune-mediated necrotizing myopathy, and overlap myositis. RECENT FINDINGS The identification of myositis-specific autoantibodies has improved the characterization of the subtypes of myositis and associated clinical phenotypes, as the severity of muscle involvement, extramuscular manifestations, and risk of malignancy may vary among the subtypes of autoimmune myopathies. SUMMARY The understanding and diagnostic accuracy of the subtypes of autoimmune ...
Source: CONTINUUM: Lifelong Learning in Neurology - December 1, 2019 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Sporadic Inclusion Body Myositis and Other Rimmed Vacuolar Myopathies
This article reviews the clinical, laboratory, and histopathologic features of sporadic inclusion body myositis (IBM) and explores its pathogenic overlap with inherited myopathies that have IBM-like pathology. RECENT FINDINGS Sporadic IBM is the most common acquired muscle disease in patients older than 50 years of age and is becoming more prevalent because of the increasing age of the population, the emerging development of more inclusive diagnostic criteria, and the advent of a diagnostic autoantibody. No effective therapy is known, and the pathogenic mechanism remains unclear. Some pathogenic insight can be gleaned f...
Source: CONTINUUM: Lifelong Learning in Neurology - December 1, 2019 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Congenital Muscular Dystrophy and Congenital Myopathy
This article summarizes the clinical and genetic aspects of these disorders. RECENT FINDINGS Historically, diagnoses of congenital muscular dystrophy and congenital myopathy have been made by clinical features and histopathology; however, recent advances in genetics have changed diagnostic practice by relying more heavily on genetic findings. This article reviews the clinical and genetic features of the most common congenital muscular dystrophies including laminin subunit alpha 2 (LAMA2)–related (merosin deficient), collagen VI–related, and α-dystroglycan–related congenital muscular dystrophies and reviews the mo...
Source: CONTINUUM: Lifelong Learning in Neurology - December 1, 2019 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Toxic Myopathies
This article reviews the pathogenesis, clinical features, and management of toxic myopathy related to common medications, critical illness, and illicit substances. RECENT FINDINGS Muscle symptoms are common among statin users and are usually reversible after discontinuation of the statin; rarely, however, statins trigger an immune-mediated necrotizing myopathy that persists and requires immunomodulatory therapy. Autoantibodies targeting 3-hydroxy-3-methylglutaryl coenzyme A reductase can distinguish the toxic and immune-mediated forms. Immune checkpoint inhibitors, increasingly used in the treatment of advanced cancer, ...
Source: CONTINUUM: Lifelong Learning in Neurology - December 1, 2019 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Mitochondrial and Metabolic Myopathies
This article provides an overview of mitochondrial and metabolic biology, the genetic mechanisms causing mitochondrial diseases, the clinical features of mitochondrial diseases, lipid myopathies, and glycogen storage diseases, all with a focus on those syndromes and diseases associated with myopathy. Over the past decade, advances in genetic testing have revolutionized patient evaluation. The main goal of this review is to give the clinician the basic understanding to recognize patients at risk of these diseases using the standard history and physical examination. RECENT FINDINGS Primary mitochondrial disease is the cur...
Source: CONTINUUM: Lifelong Learning in Neurology - December 1, 2019 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Inspiratory muscle training for advanced heart failure with lamin-related muscular dystrophy
Publication date: Available online 29 October 2019Source: Journal of Cardiology CasesAuthor(s): Masanobu Taya, Eisuke Amiya, Masaru Hatano, Hisataka Maki, Yumiko Hosoya, Junichi Ishida, Chie Bujo, Masaki Tsuji, Yuto Konishi, Kazuhiko Yokota, Nobuhiko Haga, Issei KomuroAbstractRespiratory muscle weakness is often complicated in patients with heart failure. Its presence further worsens the clinical course of heart failure. However, the effect and appropriate method of inspiratory muscle training has not previously been elucidated.A 55-year-old man with dilated cardiomyopathy was admitted for intractable heart failure. His he...
Source: Journal of Cardiology Cases - October 30, 2019 Category: Cardiology Source Type: research

Statin Induced Necrotizing Autoimmune Myopathy: An uncommon complication of a commonly used medication
We report a case of statin induced necrotizing autoimmune myopathy (SINAM), a rare variant of statin-induced myopathy.A 64-year-old gentleman on atorvastatin presented with muscle weakness, initial laboratory results showed elevated liver function tests, a creatine phosphokinase (CPK) of 8200 IU/L and positive urine myoglobin. Despite discontinuing atorvastatin, his CPK remained persistently elevated. Muscle biopsy was consistent with necrotizing myopathy. Anti - HMG CoA reductase antibody was strongly positive. Steroids followed by intravenous immunoglobulin were given. His muscle weakness, CPK, and liver functions gradua...
Source: Journal of the Saudi Heart Association - August 15, 2019 Category: Cardiology Source Type: research