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Specialty: Biochemistry

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Total 24 results found since Jan 2013.

Comparison of acid and water-soluble chitosan doped fibrous cellulose hemostat wet laid nonwoven web for hemorrhage application.
Abstract Fibrous hemostat was produced using wet laying technique comprising of acid and water soluble chitosan with fibrous cellulose. The hemostatic efficiency and their structural properties were evaluated using blood clotting time, whole blood adhesion and analytical characterization techniques. The maximum concentration of chitosan utilised for the production of nonwoven was 1.5 w/v % upon which increased the viscosity of the solution. The absorption of phosphate buffer solution was found to be 1117% for acid soluble chitosan based nonwoven whereas for water soluble chitosan based nonwoven was 997%. Increase...
Source: International Journal of Biological Macromolecules - January 14, 2020 Category: Biochemistry Authors: Hemamalini T, Vikash N, Brindha P, Abinaya M, Dev VRG Tags: Int J Biol Macromol Source Type: research

An Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel.
Abstract We have developed a new hydrogel hemostat composed of hyaluronan (HA) conjugated with inorganic polyphosphate (PolyP). A hemostatic hydrogel, HAX-PolyP, was formed rapidly by mixing aldehyde-modified HA and hydrazide-modified HA conjugated with PolyP (HA-PolyP). Although the gelation rate decreased with increasing PolyP content, the gelation time was below 5 min. In addition, the hydrogel swelling volume decreased with increasing PolyP content, but the degradation rate did not depend on PolyP content and the hydrogel underwent complete degradation through hydrolysis over 3 weeks in phosphate buffered sali...
Source: Biomacromolecules - July 9, 2018 Category: Biochemistry Authors: Sakoda M, Kaneko M, Ohta S, Qi P, Ichimura S, Yatomi Y, Ito T Tags: Biomacromolecules Source Type: research

Physico-mechanical and biological evaluation of an injectable m-TG cross-linked thrombin loaded amended gelatin hemostat to heal liver trauma
The objective of this study was to evaluate the activation of a coagulation system both in vitro and in vivo. We assessed detailed physical characteristics of a microbial transglutaminase (m-TG) crosslinked thrombin (TB) laden Gelatin (Gel) hemostat sealant in vitro and its hemostatic efficacy for controlling bleeding caused by liver trauma in rats as well as its efficacy for organ regeneration after making a critical defect. The prepared hemostat gel showed almost seven times higher absorbance behavior than a negative control. Thrombogenicity of the prepared gel was determined based on platelet adhesion, whole blood clott...
Source: International Journal of Biological Macromolecules - March 30, 2021 Category: Biochemistry Authors: Thanh Lan Chu Garima Tripathi Bae Sang Ho Byong-Taek Lee Source Type: research

Starch-derived absorbable polysaccharide hemostat enhances bone healing via BMP-2 protein.
In this study, we used a model of rabbit parietal bone defect and a mouse osteoblast cell line MC3T3-E1 to evaluate the effects of SAPH on bone healing. We found that SAPH significantly decreased bone healing scores, reduced defective area of parietal bone, and increased the areas of bone trabeculae and cavitas medullaris. In addition, SAPH enhanced MC3T3-E1 osteoblasts proliferation, up-regulated the expressions of alkaline phosphatase (ALP) and osteocalcin and increased the level of bone morphogenetic protein 2 (BMP-2) in MC3T3-E1 osteoblasts. These SAPH-induced benefits in MC3T3-E1 osteoblasts were significantly abolish...
Source: Acta Histochemica - February 2, 2017 Category: Biochemistry Authors: Niu W, Wang Y, Liu Y, Zhang B, Liu M, Luo Y, Zhao P, Zhang Y, Wu H, Ma L, Li Z Tags: Acta Histochem Source Type: research

Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding.
Abstract Lethal bleeding due to street accidents, natural calamities, orthopedic/dental surgeries, organ transplantation and household injuries, is the leading cause of morbidity and mortality. In the current study, zinc oxide (ZnO) was incorporated in TEMPO-oxidized cellulose nanofiber (TOCN) and polyethylene glycol (PEG) polymer system for hemorrhage control by freeze drying method. SEM and XRD data showed the presence of ZnO in the porous structure. FT-IR analysis showed that, successful conjugation occurs among the TOCN and PEG. The results revealed that, the incorporation of ZnO and higher concentrations of P...
Source: International Journal of Biological Macromolecules - December 8, 2018 Category: Biochemistry Authors: Shefa AA, Taz M, Hossain M, Kim YS, Lee SY, Lee BT Tags: Int J Biol Macromol Source Type: research

Recombinant batroxobin-coated nonwoven chitosan as hemostatic dressing for initial hemorrhage control.
In conclusion, hemostasis can be improved by combining a chitosan-based nonwoven dressing with other agents, and rBat-coated chitosan-based nonwoven dressings have enormous potential to improve blood coagulation. PMID: 29514041 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - March 4, 2018 Category: Biochemistry Authors: Seon GM, Lee MH, Kwon BJ, Kim MS, Koo MA, Seomun Y, Kim JT, Kim TH, Park JC Tags: Int J Biol Macromol Source Type: research

Fabrication of porous starch microspheres by electrostatic spray and supercritical CO2 and its hemostatic performance.
Abstract Effective control of bleeding is critical to saving lives whether on the battle field or in civilian life. Microporous starch (MS) is a promising hemostat for its extensive sources, huge surface area and good biocompatibility. However, the hemostatic performance of MS is limited because of its complex preparation process and lack of effective component to activate coagulation factors. Herein, porous starch microspheres modified by calcium (Ca-PSM) with dense shell and honeycomb micro-porous core were prepared by electrostatic spray and supercritical CO2 for the first time. The topological morphology of Ca...
Source: International Journal of Biological Macromolecules - November 4, 2018 Category: Biochemistry Authors: Chen J, Chen S, Cheng W, Lin J, Hou S, Liu H, Chen Q Tags: Int J Biol Macromol Source Type: research

Rational design of porous starch/hyaluronic acid composites for hemostasis.
Abstract Effective hemorrhage control is pivotal for decreasing the trauma death both in civilian and military but has proven to be dauntingly challenging, especially for solid viscera and artery trauma. Here we report the fabrication of a novel starch-based hemostat, sodium trimethaphosphate (STMP)-crosslinked starch/hyaluronic acid (HA) (ScSH) porous composites. Aiming at hemostatic potential, physicochemical properties, cytocompatibility, hemocompatibility, histocompatibility and hemostatic performance of ScSH composites have been studied. As it turned out, the incorporation of HA greatly improved the water abs...
Source: International Journal of Biological Macromolecules - May 5, 2020 Category: Biochemistry Authors: Wang Y, Liu G, Wu L, Qu H, Song D, Huang H, Wu C, Xu M Tags: Int J Biol Macromol Source Type: research

A Nanostructured Synthetic Collagen Mimic for Hemostasis.
In this report, we utilize this nanofiber forming collagen mimetic peptide as a synthetic biomimetic matrix useful in thrombosis. We demonstrate that nanofibrous KOD synthetic collagen matrices adhere platelets, activate them (indicated by soluble P-selectin secretion), and clot plasma and blood similar to animal derived collagen and control surfaces. In addition to the thrombotic potential, THP-1 monocytes incubated with our KOD collagen mimetic showed minimal proinflammatory cytokine (TNF-α or IL-1β) production. Together, the data presented demonstrates the potential of a novel synthetic collagen mimetic as a hemostat....
Source: Biomacromolecules - April 2, 2014 Category: Biochemistry Authors: Kumar VA, Taylor NL, Jalan AA, Hwang LK, Wang BK, Hartgerink JD Tags: Biomacromolecules Source Type: research

Black hemostatic sponge based on facile prepared cross-linked graphene
In this study, we demonstrate for the first time the remarkable hemostatic performance of a cross-linked graphene sponge (CGS) as a superb hemostat. The CGS can absorb plasma immediately (<40ms) to form a blood cell layer and promote subsequent clotting. The interaction between the interface of the CGS and blood cells reveals that the fast blood coagulation is primarily attributed to the enrichment of hemocytes and platelets on the wound surface. An in vitro dynamic whole-blood clotting test further highlights the effectiveness of the CGS. Considering the facile preparation, low cost, nontoxicity and long shelf life...
Source: Colloids and Surfaces B: Biointerfaces - May 12, 2015 Category: Biochemistry Source Type: research

Graphene-kaolin composite sponge for rapid and riskless hemostasis
Publication date: 1 September 2018 Source:Colloids and Surfaces B: Biointerfaces, Volume 169 Author(s): Yuping Liang, Congcong Xu, Guofeng Li, Tianchi Liu, Jun F. Liang, Xing Wang Kaolin is an effective and safe hemostatic agent for hemostasis. However, its ontic powder is difficult to use in actual practice. To develop a wieldy and powerful hemostat, composite strategy is usually a good choice. Herein, we developed a graphene-kaolin composite sponge (GKCS), synthesized with graphene oxide sheets, linker molecules and kaolin powders through a facile hydrothermal reaction. SEM observations support that GKCS has a porous st...
Source: Colloids and Surfaces B: Biointerfaces - May 17, 2018 Category: Biochemistry Source Type: research

Porous electrospun starch rich polycaprolactone blend nanofibers for severe hemorrhage.
Abstract Starch nanofiber based hemostat was prepared by electrospinning process for biomedical applications. Bead free uniform starch nanofiber along with polycaprolactone polymer was produced using new solvent combination. The swelling of the PCL/starch mat was 240% higher compared to pristine PCL mat. The blood clotting time of the developed PCL/starch mat was 156 s and the contact angle was 30.8°. The results suggest that the developed nanofibers exhibited good hemostatic potential with quick rate of clotting to control blood loss in traumatic injuries. PMID: 29964114 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - June 29, 2018 Category: Biochemistry Authors: Giri Dev VR, Hemamalini T Tags: Int J Biol Macromol Source Type: research

Efficient antibacterial dextran-montmorillonite composite sponge for rapid hemostasis with wound healing.
Abstract Montmorillonite (MMT) powder, as the most effective hemostats in natural silicates, is restricted for commercial application due to its embolic effect. Until now, it's still a challenge to control the leakage of MMT and avoid its side-effects. Herein, poly aldehyde dextran (PDA)/MMT composite sponge (PM) with commendable tissue adhesion, antibacterial, and wound healing performances is developed for massive hemorrhage control. Based on the high degree of perfect synergism of PDA and MMT, the PM sponge can rapidly seal the wound, and promote cells aggregation and adhesion, whole coagulation system activati...
Source: International Journal of Biological Macromolecules - May 20, 2020 Category: Biochemistry Authors: Liu C, Liu C, Yu S, Wang N, Yao W, Liu X, Sun G, Song Q, Qiao W Tags: Int J Biol Macromol Source Type: research