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Hemostatic Efficacy and Biocompatibility Evaluation of a Novel Absorbable Porous Starch Hemostat
CONCLUSION: According to our study, Ca2+CPSM could effectively achieve hemostasis in the standard rat liver injury model and exhibited good blood compatibility and in vivo tissue compatibility. These finding suggested that Ca2+CPSM as a new kind of APSH had its extensive clinical application value.PMID:34551638 | DOI:10.1177/15533506211046100
Source: Surgical Innovation - September 23, 2021 Category: Surgery Authors: Jianjun Zhu Zhuona Wu Wenzhong Sun Zhiyun Meng Xiaoxia Zhu Hui Gan Ruolan Gu Xuan Guo Guifang Dou Source Type: research

Fabrication of chitosan@calcium alginate microspheres with porous core and compact shell, and application as a quick traumatic hemostat
Publication date: Available online 24 June 2020Source: Carbohydrate PolymersAuthor(s): Xiaowei Wu, Zonghao Tang, Xiaoming Liao, Zhengchao Wang, Haiqing Liu
Source: Carbohydrate Polymers - June 27, 2020 Category: Biomedical Science Source Type: research

Thermal Treatment Stimulus on Erythrocyte Compatibility and Hemostatic Behaviour of One-Dimensional Bioactive Nano-Structures.
This study identifies the role and significance of heat treatment parameters on blood compatibility and hemostatic performances. Bioactive nanomaterials step-annealed at 550 °C and 600 °C enhances the biocompatibility due to the liberation of nitrate content. This also develops the anisotropic structures such as needle-like and rod-like appearances that positively improve the erythrocyte compatibility. Different stable crystalline phases such as NaCaPO4 , Na2 Ca2 Si3 O9 and Na1.8 Ca1.1 Si6 O14 were observed for all the bioactive materials, while in the case of 800 °C phase transition of Na3 CaPSiO7 was perceived along w...
Source: Biomed Res - May 2, 2020 Category: Research Authors: Chitra S, Bargavi P, Chandran RR, Balakumar S Tags: J Biomed Mater Res A Source Type: research

Hemostasis and Bone Regeneration Using Chitosan/Gelatin-BCP Bi-layer Composite Material
The aim of the study was to determine the hemostatic activity of a composite bi-layered topical hemostat composed of electrospun gelatin loaded with bi-phasic calcium phosphate and chitosan layer and its effect on bone formation. Morphology of the composite hemostat and its individual components were observed using scanning electron microscopy. In vitro biocompatibility of the topical hemostat tested using preosteoblasts cells (MC3t3-E1) showed no adverse toxicity. Confocal microscopy of seeded cells showed good cell adhesion while 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated 15% incre...
Source: ASAIO Journal - July 30, 2019 Category: Medical Devices Tags: Tissue Engineering/ Biomaterials Source Type: research

Fabrication of porous starch microspheres by electrostatic spray and supercritical CO2 and its hemostatic performance.
Abstract Effective control of bleeding is critical to saving lives whether on the battle field or in civilian life. Microporous starch (MS) is a promising hemostat for its extensive sources, huge surface area and good biocompatibility. However, the hemostatic performance of MS is limited because of its complex preparation process and lack of effective component to activate coagulation factors. Herein, porous starch microspheres modified by calcium (Ca-PSM) with dense shell and honeycomb micro-porous core were prepared by electrostatic spray and supercritical CO2 for the first time. The topological morphology of Ca...
Source: International Journal of Biological Macromolecules - November 4, 2018 Category: Biochemistry Authors: Chen J, Chen S, Cheng W, Lin J, Hou S, Liu H, Chen Q Tags: Int J Biol Macromol Source Type: research

Dabbling in Dentistry
Most people will experience dental pain or a dental complication at some point in their lives. Dental pain is an incredibly common complaint by people of all ages, especially those who lack dental insurance and suitable hygiene habits. Sometimes, though, poor dentition or injury is simply a result of bad luck. Patients often present to the ED hoping to find a dentist and an answer to their problems.   Your first thought? “I am not a dentist. What am I going to do?” You’re right to an extent. We are not dentists, and often feel we have little to offer patients for acute issues that require equipment we don’t have...
Source: The Procedural Pause - July 1, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs