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Total 5140 results found since Jan 2013.

Viruses, Vol. 15, Pages 1952: Real-World Experience of the Comparative Effectiveness and Safety of Combination Therapy with Remdesivir and Monoclonal Antibodies versus Remdesivir Alone for Patients with Mild-to-Moderate COVID-19 and Immunosuppression: A Retrospective Single-Center Study in Aichi, Japan
Hiroshige Mikamo The coronavirus disease (COVID-19) pandemic continues to threaten global public health. Remdesivir and monoclonal antibodies have shown promise for COVID-19 treatment of patients who are immunocompromised, including those with cancer, transplant recipients, and those with autoimmune disorder. However, the effectiveness and safety of this combination therapy for patients who are immunosuppressed remain unclear. We compared the efficacy and safety of combination therapy and remdesivir monotherapy for patients with mild-to-moderate COVID-19 who were immunosuppressed. Eighty-six patients treated in July 2...
Source: Viruses - September 19, 2023 Category: Virology Authors: Jun Hirai Nobuaki Mori Daisuke Sakanashi Wataru Ohashi Yuichi Shibata Nobuhiro Asai Hideo Kato Mao Hagihara Hiroshige Mikamo Tags: Article Source Type: research

Relationship between clinical symptom profiles and COVID-19 infection status during delta-dominant period versus omicron-dominant period – analysis of real-world data collected in Hiroshima Prefecture, Japan
COVID-19, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) spread rapidly around the world after December 2019, when the first case was diagnosed in Wuhan City, Hubei Province, China. As of 5 March 2023, over 759 million confirmed cases and over 6.8 million deaths have been reported globally [1]. In Japan, the first domestic case of COVID-19 transmission was reported on January 16, 2020 [2], and the pandemic has now entered its fourth year. Throughout this time, governments around the world have taken various preventative measures in response to the pandemic, from mask wearing and social distancing ...
Source: International Journal of Infectious Diseases - September 15, 2023 Category: Infectious Diseases Authors: Lola Mamazairovna Hujamberdieva, Odgerel Chimed-Ochir, Yui Yumiya, Junko Tanaka, Hiroki Ohge, Masao Kuwabara, Eisaku Kishita, Tatsuhiko Kubo Source Type: research

Viruses, Vol. 15, Pages 1914: Nonlinear and Multidelayed Effects of Meteorological Drivers on Human Respiratory Syncytial Virus Infection in Japan
In this study, we aimed to characterize the nonlinear and multidelayed effects of multiple meteorological drivers on human respiratory syncytial virus (HRSV) infection epidemics in Japan. The prefecture-specific weekly time-series of the number of newly confirmed HRSV infection cases and multiple meteorological variables were collected for 47 Japanese prefectures from 1 January 2014 to 31 December 2019. We combined standard time-series generalized linear models with distributed lag nonlinear models to determine the exposure–lag–response association between the incidence relative risks (IRRs) of ...
Source: Viruses - September 12, 2023 Category: Virology Authors: Keita Wagatsuma Iain S. Koolhof Reiko Saito Tags: Article Source Type: research

Analysis of the short-term outcomes after esophagectomy for esophageal cancer during the COVID-19 pandemic using data from a nationwide Japanese database
ConclusionsEsophagectomy was performed during the pandemic despite limited medical resources by a systematic endeavor of the entire surgical department in Japan, without increasing the incidence rate of worse outcome.
Source: Esophagus - September 11, 2023 Category: Gastroenterology Source Type: research

Impact of visiting restrictions on Edinburgh postnatal depression scale screening scores at one month postpartum during the spread of COVID-19: a single-center case-control study in Japan
This study aimed to evaluate whether “visiting restrictions” implemented due to the coronavirus disease 2019 (COVID-19) pandemic are a risk factor for postpartum depression using the Edinburgh Postnatal Depres...
Source: BMC Pregnancy and Childbirth - September 9, 2023 Category: OBGYN Authors: Sho Kudo, Harumichi Banno, Taro Itou, Hiroshi Kawamura, Daisuke Inoue, Nozomu Takahashi, Makoto Orisaka and Yoshio Yoshida Tags: Research Source Type: research

Investigation of the individual genetic evolution of SARS-CoV-2 in a small cluster during the rapid spread of the BF.5 lineage in Tokyo, Japan
There has been a decreasing trend in new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases and fatalities worldwide. The virus has been evolving, indicating the potential emergence of new variants and uncertainties. These challenges necessitate continued efforts in disease control and mitigation strategies. We investigated a small cluster of SARS-CoV-2 Omicron variant infections containing a common set of genomic mutations, which provided a valuable model for investigating the transmission mechanism of genetic alterations. We conducted a study at a medical center in Japan during the Omicron surge (sub-line...
Source: Frontiers in Microbiology - September 6, 2023 Category: Microbiology Source Type: research

Effect of a Family Pharmacist System on Medication Adherence of Patients with Dyslipidemia during a COVID-19 Epidemic
In this study, using anonymously processed receipt data from 700 insurance pharmacies in our group, we evaluated medication adherence in patients taking statin drugs before, during the first and second years of coronavirus disease 2019 (COVID-19) epidemic in terms of medication persistence and medication possession, and compared the results between the family pharmacist group (FP group) and non-family pharmacist group (NoFP group). The odds ratios of good medication adherence (medication persistence and medication possession) rates for the FP group relative to the NoFP group were 1.446 [95% confidence interval (CI): 1.210-...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 4, 2023 Category: Drugs & Pharmacology Authors: Mamoru Maeda Yoshitaka Hasegawa Ryota Tsukioka Miya Oishi Source Type: research