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Therapy: Immunotherapy
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Total 29516 results found since Jan 2013.
Re-routing the GPS directing immunotherapy in endometrial cancer
Clin Cancer Res. 2023 Sep 12. doi: 10.1158/1078-0432.CCR-23-1953. Online ahead of print.ABSTRACTMMR status alone is insufficient to guide the use of PD-(L)1 monotherapy in endometrial cancer patients. Additional biomarkers, including TMB and CPS score may help to identify patients with pMMR tumors with a high probability of benefit from PD-(L)1 monotherapy, and those with dMMR tumors who might require combination strategies.PMID:37698948 | DOI:10.1158/1078-0432.CCR-23-1953
Source: Clinical Cancer Research - September 12, 2023 Category: Cancer & Oncology Authors: Rhea Jangra Neesha C Dhani Source Type: research
Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma
CONCLUSIONS: Seven MiAg-related genes were identified to be significantly associated with the prognosis of patients diagnosed with LUAD. Moreover, the identified MiAg DEGs might affect the immunotherapy strategy of patients with LUAD.PMID:37698683 | DOI:10.1007/s00432-023-05390-x
Source: Clinical Lung Cancer - September 12, 2023 Category: Cancer & Oncology Authors: Xiangzhi Meng Weijian Song Boxuan Zhou Mei Liang Yushun Gao Source Type: research
Modern therapies of nonsmall cell lung cancer
J Appl Genet. 2023 Sep 12. doi: 10.1007/s13353-023-00786-4. Online ahead of print.ABSTRACTLung cancer (LC), particularly nonsmall cell lung cancer (NSCLC), is one of the most prevalent types of neoplasia worldwide, regardless of gender, with the highest mortality rates in oncology. Over the years, treatment for NSCLC has evolved from conventional surgery, chemotherapy, and radiotherapy to more tailored and minimally invasive approaches. The use of personalised therapies has increased the expected efficacy of treatment while simultaneously reducing the frequency of severe adverse effects (AEs). In this review, we discuss es...
Source: J Appl Genet - September 12, 2023 Category: Genetics & Stem Cells Authors: Andrzej Jachowski Miko łaj Marcinkowski Jakub Szyd łowski Oskar Grabarczyk Zuzanna Nogaj Łaz Marcin Andrzej P ławski Pawe ł Piotr Jagodziński Bartosz Kazimierz S łowikowski Source Type: research
Integrated clustering signature of genomic heterogeneity, stemness and tumor microenvironment predicts glioma prognosis and immunotherapy response
CONCLUSIONS: This study identified risk hub genes and established a risk model by analyzing the genomic heterogeneity, stemness, and immune microenvironment of glioma. Our findings will facilitate the diagnosis and prediction of glioma prognosis and may lead to potential treatment strategies for glioma.PMID:37698534 | DOI:10.18632/aging.205018
Source: Aging - September 12, 2023 Category: Biomedical Science Authors: Yangyang Wu Meng Mao Lin-Jian Wang Source Type: research
Modern therapies of nonsmall cell lung cancer
J Appl Genet. 2023 Sep 12. doi: 10.1007/s13353-023-00786-4. Online ahead of print.ABSTRACTLung cancer (LC), particularly nonsmall cell lung cancer (NSCLC), is one of the most prevalent types of neoplasia worldwide, regardless of gender, with the highest mortality rates in oncology. Over the years, treatment for NSCLC has evolved from conventional surgery, chemotherapy, and radiotherapy to more tailored and minimally invasive approaches. The use of personalised therapies has increased the expected efficacy of treatment while simultaneously reducing the frequency of severe adverse effects (AEs). In this review, we discuss es...
Source: J Appl Genet - September 12, 2023 Category: Genetics & Stem Cells Authors: Andrzej Jachowski Miko łaj Marcinkowski Jakub Szyd łowski Oskar Grabarczyk Zuzanna Nogaj Łaz Marcin Andrzej P ławski Pawe ł Piotr Jagodziński Bartosz Kazimierz S łowikowski Source Type: research
Prognostic and immunological roles of IL18RAP in human cancers
In this study, based on bioinformatics analysis, we discovered that IL18RAP is related to the human tumor microenvironment and promotes various immune cells infiltration. Additionally, the multiple immunofluorescence staining revealed that with the increased expression of IL18RAP, the number of infiltrated M1 macrophages increased. This finding was confirmed by coculture migration analysis using three human cancer cell lines (MDA-MB-231, U251, and HepG2) with IL18RAP knockdown. We discovered a positive link between IL18RAP and the majority of immunostimulators, immunoinhibitors, major histocompatibility complex (MHC) molec...
Source: Aging - September 12, 2023 Category: Biomedical Science Authors: Wu Chen Tianbao Song Fan Zou Yuqi Xia Ji Xing Weimin Yu Ting Rao Xiangjun Zhou Chenglong Li Jinzhuo Ning Sheng Zhao Yuan Ruan Fan Cheng Source Type: research
Radiomics Correlation to CD68+ Tumor-Associated Macrophages in Clear Cell Renal Cell Carcinoma
CONCLUSION: Our study demonstrates the potential of using CT radiomics derived imaging markers as a surrogate for assessment of TAM in ccRCC for real time treatment response monitoring and patient selection for targeted therapies and immunotherapies.PMID:37699367 | DOI:10.1159/000534078
Source: Oncology - September 12, 2023 Category: Cancer & Oncology Authors: Alexander Shieh Steven Y Cen Bino A Varghese Darryl Hwang Xiaomeng Lei Ali Setayesh Imran Siddiqi Manju Aron Anishka Dsouza Inderbir S Gill William Wallace Vinay Duddalwar Source Type: research
Pan-Cancer Analysis of the Prognostic and Immunological Role of SMG5: A biomarker for cancers
CONCLUSION: SMG5 is differentially expressed in several cancers and is significantly associated with prognosis, immune microenvironment and immune checkpoints in LGG patients. Therefore, SMG5 could be a potential pan-cancer biomarker and an immunotherapeutic target for LGG.PMID:37699361 | DOI:10.1159/000533421
Source: Oncology - September 12, 2023 Category: Cancer & Oncology Authors: Leteng Yang Jie Wei Xiaoya Ma Huan Zhang Tianbo Jin Source Type: research
Activation and differentiation of cognate T cells by a dextran-based antigen-presenting system for cancer immunotherapy
This article is protected by copyright. All rights reserved.PMID:37698527 | DOI:10.1002/eji.202350528
Source: European Journal of Immunology - September 12, 2023 Category: Allergy & Immunology Authors: Dhrubajyoti Mahata Debangshu Mukherjee Debarati Biswas Shyam Basak Aditya Jyoti Basak Imlilong Jamir Nidhi Pandey Huma Khatoon Dibyendu Samanta Amit Basak Gayatri Mukherjee Source Type: research
Radiomics Correlation to CD68+ Tumor-Associated Macrophages in Clear Cell Renal Cell Carcinoma
CONCLUSION: Our study demonstrates the potential of using CT radiomics derived imaging markers as a surrogate for assessment of TAM in ccRCC for real time treatment response monitoring and patient selection for targeted therapies and immunotherapies.PMID:37699367 | DOI:10.1159/000534078
Source: Oncology - September 12, 2023 Category: Cancer & Oncology Authors: Alexander Shieh Steven Y Cen Bino A Varghese Darryl Hwang Xiaomeng Lei Ali Setayesh Imran Siddiqi Manju Aron Anishka Dsouza Inderbir S Gill William Wallace Vinay Duddalwar Source Type: research
Pan-Cancer Analysis of the Prognostic and Immunological Role of SMG5: A biomarker for cancers
CONCLUSION: SMG5 is differentially expressed in several cancers and is significantly associated with prognosis, immune microenvironment and immune checkpoints in LGG patients. Therefore, SMG5 could be a potential pan-cancer biomarker and an immunotherapeutic target for LGG.PMID:37699361 | DOI:10.1159/000533421
Source: Oncology - September 12, 2023 Category: Cancer & Oncology Authors: Leteng Yang Jie Wei Xiaoya Ma Huan Zhang Tianbo Jin Source Type: research
Unlocking therapeutic potential: integration of drug repurposing and immunotherapy for various disease targeting
Am J Transl Res. 2023 Aug 15;15(8):4984-5006. eCollection 2023.ABSTRACTDrug repurposing, also known as drug repositioning, entails the application of pre-approved or formerly assessed drugs having potentially functional therapeutic amalgams for curing various disorders or disease conditions distinctive from their original remedial indication. It has surfaced as a substitute for the development of drugs for treating cancer, cardiovascular diseases, neurodegenerative disorders, and various infectious diseases like Covid-19. Although the earlier lines of findings in this area were serendipitous, recent advancements are based ...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Vishakha Anand Pawar Anuradha Tyagi Chaitenya Verma Kanti Prakash Sharma Sekhu Ansari Indra Mani Shailesh Kumar Srivastva Pradeep Kumar Shukla Antresh Kumar Vinay Kumar Source Type: research
Matrine improves the hepatic microenvironment and reverses epithelial-mesenchymal transition in hepatocellular carcinoma by inhibiting the Wnt-1/ β-catenin signaling pathway
CONCLUSIONS: Matrine can reverse EMT, alleviate intrahepatic inflammation, and counteract immune depletion by inhibiting the Wnt-1/β-catenin signaling pathway in HCC.PMID:37692966 | PMC:PMC10492086
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Jianfei Shi Hua Zhang Guangjie Han Jinfeng Wang Xin Han Man Zhao Xiaoling Duan Lili Mi Ning Li Xiaolei Yin Cuizhen Li Fei Yin Source Type: research
Developing a novel necroptosis-related signature to evaluate the prognostic and therapeutic characteristics of esophageal cancer
CONCLUSION: A necroptosis-related prognostic signature was developed to study the tumor microenvironment, mutational burden, clinical features, and the treatment response of ESCA patients. This may contribute to precision medicine for ESCA.PMID:37692951 | PMC:PMC10492067
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Mingzhi Chen Tianzhen Hua Lanjie Yang Chunzhen Li Shuhua Xu Ji Zhu Tiejun Zhao Source Type: research
