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Total 73464 results found since Jan 2013.
Dietary palm oil enhances SREBP2-mediated cholesterol biosynthesis through inducing endoplasmic reticulum stress in muscle of large yellow croaker ( < em > Larimichthys crocea < /em > )
Br J Nutr. 2023 Sep 13:1-27. doi: 10.1017/S0007114523001344. Online ahead of print.ABSTRACTSterol regulatory element-binding protein 2 (SREBP2) is considered to be a major regulator to control cholesterol homeostasis in mammals. However, the role of SREBP2 in teleost remains poorly understand. Here, we explored the molecular characterization of SREBP2 and identified SREBP2 as a key modulator for 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and 7-dehydrocholesterol reductase (DHCR7) which were rate-limiting enzymes of cholesterol biosynthesis. Moreover, dietary palm oil (PO) in vivo or palmitic acid (PA) treatmen...
Source: The British Journal of Nutrition - September 12, 2023 Category: Nutrition Authors: Zengqi Zhao Baolin Li Qiang Chen Xiaojun Xiang Xiang Xu Shangzhe Han Wencong Lai Yueru Li Wei Xu Kangsen Mai Qinghui Ai Source Type: research
AI pitfalls and what not to do: Mitigating bias in AI
We describe these pitfalls by framing them in the larger AI lifecycle from problem definition, dataset selection and curation, model training and deployment emphasizing that bias exists across a spectrum and is a sequela of a combination of both human and machine factors.PMID:37698583 | DOI:10.1259/bjr.20230023
Source: The British Journal of Radiology - September 12, 2023 Category: Radiology Authors: Judy Wawira Gichoya Kaesha Thomas Leo Anthony Celi Nabile Safdar Imon Banerjee John D Banja Laleh Seyyed-Kalantari Hari Trivedi Saptarshi Purkayastha Source Type: research
Artificial intelligence in mental healthcare: a scoping review
Br J Radiol. 2023 Sep 12:20230213. doi: 10.1259/bjr.20230213. Online ahead of print.ABSTRACTArtificial intelligence is disrupting the field of mental healthcare through applications in computational psychiatry, which leverages quantitative techniques to inform our understanding, detection, and treatment of mental illnesses. This paper provides an overview of artificial intelligence technologies in modern mental healthcare and surveys recent advances made by researchers, focusing on the nascent field of digital psychiatry. We also consider the ethical implications of artificial intelligence playing a greater role in mental ...
Source: The British Journal of Radiology - September 12, 2023 Category: Radiology Authors: Kevin W Jin Qiwei Li Yang Xie Guanghua Xiao Source Type: research
AI in medical imaging grand challenges: translation from competition to research benefit and patient care
Br J Radiol. 2023 Sep 12:20221152. doi: 10.1259/bjr.20221152. Online ahead of print.ABSTRACTArtificial intelligence (AI), in one form or another, has been a part of medical imaging for decades. The recent evolution of AI into approaches such as deep learning has dramatically accelerated the application of AI across a wide range of radiologic settings. Despite the promises of AI, developers and users of AI technology must be fully aware of its potential biases and pitfalls, and this knowledge must be incorporated throughout the AI system development pipeline that involves training, validation, and testing. Grand challenges ...
Source: The British Journal of Radiology - September 12, 2023 Category: Radiology Authors: Samuel Armato Karen Drukker Lubomir Hadjiiski Source Type: research
Successes and challenges in extracting information from DICOM image databases for audit and research
Br J Radiol. 2023 Sep 12:20230104. doi: 10.1259/bjr.20230104. Online ahead of print.ABSTRACTIn radiography, much valuable associated data (metadata) is generated during image acquisition. The current setup of picture archive and communication systems (PACS) can make extraction of this metadata difficult, especially as it is typically stored with the image. The aim of this work is to examine the current challenges in extracting image metadata and to discuss the potential benefits of using this rich information. This work focuses on breast screening, though the conclusions are applicable to other modalities.The data stored i...
Source: The British Journal of Radiology - September 12, 2023 Category: Radiology Authors: Alistair Mackenzie Emma Lewis John Loveland Source Type: research
Comment on: Assessment of inter-centre agreement across multidisciplinary team meetings for patients with retroperitoneal sarcoma
Br J Surg. 2023 Sep 12:znad292. doi: 10.1093/bjs/znad292. Online ahead of print.NO ABSTRACTPMID:37699077 | DOI:10.1093/bjs/znad292
Source: The British Journal of Surgery - September 12, 2023 Category: Surgery Authors: Dimitrios Moris Dan G Blazer Source Type: research
Author response to: Comment on: Assessment of inter-centre agreement across multidisciplinary team meetings for patients with retroperitoneal sarcoma
Br J Surg. 2023 Sep 12:znad293. doi: 10.1093/bjs/znad293. Online ahead of print.NO ABSTRACTPMID:37699076 | DOI:10.1093/bjs/znad293
Source: The British Journal of Surgery - September 12, 2023 Category: Surgery Authors: Fabio Tirotta Anant Desai Source Type: research
Comment on: Personal protective equipment-induced systemic hypercapnic hypoxaemia: translational implications for impaired cognitive-clinical functional performance
Br J Surg. 2023 Sep 12:znad272. doi: 10.1093/bjs/znad272. Online ahead of print.NO ABSTRACTPMID:37699073 | DOI:10.1093/bjs/znad272
Source: The British Journal of Surgery - September 12, 2023 Category: Surgery Authors: Benjamin J Ryan Source Type: research
Sexual harassment, sexual assault and rape by colleagues in the surgical workforce, and how women and men are living different realities: observational study using NHS population-derived weights
CONCLUSION: Sexual misconduct in the past 5 years has been experienced widely, with women affected disproportionately. Accountable organizations are not regarded as dealing adequately with this issue.PMID:37697690 | DOI:10.1093/bjs/znad242
Source: The British Journal of Surgery - September 12, 2023 Category: Surgery Authors: Christopher T Begeny Homa Arshad Tamzin Cuming Daljit K Dhariwal Rebecca A Fisher Marieta D Franklin Philippa M Jackson Greta M McLachlan Rosalind H Searle Carrie Newlands Source Type: research
Conceptualizing multiplicity spectrum experiences: A systematic review and thematic synthesis
DISCUSSION: This review highlights heterogeneity within multiplicity-spectrum experiences, emphasizing the need for person-centred, individualized understanding, separate from mental health conceptualizations. Therefore, training in person-centred individualized care to promote self-concept clarity is needed across health, education and social care. This systematic review is the first to synthesize voices of people with lived experience across the multiplicity spectrum, demonstrating how qualitative research can contribute to advancing our understanding of this complex phenomena with the community, acknowledging reciprocal...
Source: Clinical Psychology and Psychotherapy - September 12, 2023 Category: Psychiatry Authors: Zarah Eve Kim Heyes Sarah Parry Source Type: research
Sexual harassment, sexual assault and rape by colleagues in the surgical workforce, and how women and men are living different realities: observational study using NHS population-derived weights
CONCLUSION: Sexual misconduct in the past 5 years has been experienced widely, with women affected disproportionately. Accountable organizations are not regarded as dealing adequately with this issue.PMID:37697690 | DOI:10.1093/bjs/znad242
Source: The British Journal of Surgery - September 12, 2023 Category: Surgery Authors: Christopher T Begeny Homa Arshad Tamzin Cuming Daljit K Dhariwal Rebecca A Fisher Marieta D Franklin Philippa M Jackson Greta M McLachlan Rosalind H Searle Carrie Newlands Source Type: research
Fatigue recovery and connected factors following paediatric concussion
CONCLUSION: Our findings confirm that fatigue improves during the first 3 months postconcussion and highlights the importance of considering child and parent mental health screening when assessing patients with persisting postconcussive symptoms.PMID:37699656 | DOI:10.1136/bjsports-2023-106894
Source: British Journal of Sports Medicine - September 12, 2023 Category: Sports Medicine Authors: Fabian Fabiano Michael Takagi Nicholas Anderson Franz E Babl Silvia Bressan Cathriona Clarke Katie Davies Gavin A Davis Kevin Dunne Stephen Hearps Vera Ignjatovic Vanessa C Rausa Marc Seal Vicki Anderson Source Type: research
Sexual misconduct in surgery? STOP!
Br J Surg. 2023 Sep 12:znad267. doi: 10.1093/bjs/znad267. Online ahead of print.NO ABSTRACTPMID:37697663 | DOI:10.1093/bjs/znad267
Source: The British Journal of Surgery - September 12, 2023 Category: Surgery Authors: Malin Sund Desmond C Winter Source Type: research
Exploring the pain and disability continuum in adolescents with non-traumatic anterior knee pain: a mediation analysis using individual participant data of prospective studies
CONCLUSION: We found an effect of pain on sports-related disability at 6 months which appears to be independent of lower extremity muscle strength, or depression/anxiety and knee confidence in adolescents with non-traumatic anterior knee pain.PMID:37699655 | DOI:10.1136/bjsports-2023-107177
Source: British Journal of Sports Medicine - September 12, 2023 Category: Sports Medicine Authors: Sinead Holden Hopin Lee Marienke van Middelkoop Adolescent Knee Health Group Michael Skovdal Rathleff adolescent knee health group Source Type: research
Epidemiology of Spinocerebellar Ataxias in Europe
Cerebellum. 2023 Sep 12. doi: 10.1007/s12311-023-01600-x. Online ahead of print.ABSTRACTSpinocerebellar ataxias (SCAs) are a heterogenous group of rare neurodegenerative conditions sharing an autosomal dominant pattern of inheritance. More than 40 SCAs have been genetically determined. However, a systematic review of SCA epidemiology in Europe is still missing. Here we performed a narrative review of the literature on the epidemiology of the most common SCAs in Europe. PubMed, Embase, and MEDLINE were searched from inception until 1 April 2023. All English peer-reviewed articles published were considered and then filtered ...
Source: Cerebellum - September 12, 2023 Category: Neuroscience Authors: Filippo De Mattei Fabio Ferrandes Salvatore Gallone Antonio Canosa Andrea Calvo Adriano Chi ò Rosario Vasta Source Type: research
