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Procedure: Liver Transplant

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Total 13196 results found since Jan 2013.

Search for Genetic Modifiers of PSC: Time to Increase the Number of Needles in the Haystack.
Authors: Krawczyk M, Lammert F Abstract Primary sclerosing cholangitis (PSC) belongs to the most obscure liver diseases. Patients with progressive PSC require liver transplantation as only therapeutic option. Previously several HLA- and non-HLA-associated PSC risk variants have been discovered, however their involvement in the development of PSC seems to be minor in comparison to environmental determinants. Lately, variant rs853974 at the RSPO3 gene locus has been shown to modulate the course of PSC. Here we briefly discuss the phenotypes related to this polymorphism and propose alternative directions of research t...
Source: Annals of Hepatology - October 24, 2017 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The search for noninvasive methods to identify liver fibrosis in children with nonalcoholic fatty liver disease.
Authors: Mandelia C, Kabbany MN, Conjeevaram Selvakumar PK, Alkhouri N Abstract Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity epidemic. Recent studies have clearly shown that the stage of fibrosis in adults with NAFLD is the most important histological feature in long-term outcomes and the development of liver-related complications. Despite the paucity of data regarding the natural history of pediatric NAFLD, its progression to cirrhosis and end-stage liver disease requiring liver transplantation is well documented. Given the high prevalence of NAFLD in children and adults, th...
Source: Future Medicine: Biomarkers in Medicine - March 10, 2018 Category: Internal Medicine Tags: Biomark Med Source Type: research

Search for Genetic Modifiers of PSC: Time to Increase the Number of Needles in the Haystack.
Authors: Krawczyk M, Lammert F Abstract Primary sclerosing cholangitis (PSC) belongs to the most obscure liver diseases. Patients with progressive PSC require liver transplantation as only therapeutic option. Previously several HLA- and non-HLA-associated PSC risk variants have been discovered, however their involvement in the development of PSC seems to be minor in comparison to environmental determinants. Lately, variant rs853974 at the RSPO3 gene locus has been shown to modulate the course of PSC. Here we briefly discuss the phenotypes related to this polymorphism and propose alternative directions of research t...
Source: Annals of Hepatology - June 9, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Contribution of Turkey in Liver Transplant Research: A Scopus Database Search
CONCLUSIONS: Among countries, Turkey had the most living donor liver transplants in 2019 and could serve as a model to European countries for donor shortages. Although the United States performs 5 times more liver transplants than Turkey, their publications rate was almost 22 times more. Combining a workload of performing research and publishing along with transplant surgery is together hard to master. Although Turkey has valuable experiences and has opened frontiers in transplantation, publications need to keep up with their hard work and innovations.PMID:35607793 | DOI:10.6002/ect.2021.0491
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 24, 2022 Category: Transplant Surgery Authors: Oru ç Numan Gökçe Sevil Alkan Source Type: research

A Case –Control Study of Maternal Polybrominated Diphenyl Ether (PBDE) Exposure and Cryptorchidism in Canadian Populations
Conclusions: Our results suggest that maternal exposure to BDE-99, -100, and -154 may be associated with abnormal migration of testes in the male fetus. This may be due to the anti-androgenic properties of the PBDEs. https://doi.org/10.1289/EHP522 Received: 17 May 2016 Revised: 22 September 2016 Accepted: 08 October 2016 Published: 26 May 2017 Address correspondence to C.G. Goodyer, Research Institute of McGill University Health Centre, Centre for Translational Biology, EM0.3211, 1001 Decarie Blvd., Montreal, QC, Canada H4A 3J1. Telephone: (514) 934-1934, ext. 22481. E-mail: cindy.goodyer@muhc.mcgill.ca Supplemental Mat...
Source: EHP Research - May 27, 2017 Category: Environmental Health Authors: Terrie Young Tags: Research Source Type: research

Outcomes of Children with Fetal and Lactation Immunosuppression Exposure Born to Female Transplant Recipients
Paediatr Drugs. 2022 Jul 23. doi: 10.1007/s40272-022-00525-y. Online ahead of print.ABSTRACTSolid organ transplantation (SOT) is a lifesaving procedure for those with end-stage kidney, liver, heart, lung, and intestinal diseases, including females of childbearing age who wish to proceed with pregnancy following transplantation. While there is clear risk associated with use of mycophenolate during pregnancy, the risks associated with use of other immunosuppressant agents are less well understood, and the timing of use in pregnancy may be pertinent when considering the risk versus benefit for individual patients. In addition...
Source: Paediatric Drugs - July 23, 2022 Category: Pediatrics Authors: Cameron J McKinzie Jillian P Casale Jack C Guerci Alyson Prom Christina T Doligalski Source Type: research

Interventions for preventing thrombosis in solid organ transplant recipients
CONCLUSIONS: Overall, there is a paucity of research in the field of graft thrombosis prevention. Due to a lack of high quality evidence, it remains unclear whether any therapy is able to reduce the rate of early graft thrombosis in any type of solid organ transplant. UFH may increase the risk of major bleeding in kidney transplant recipients, however this is based on low certainty evidence. There is no evidence from RCTs to guide anti-thrombotic strategies in liver, heart, lung, or other solid organ transplants. Further studies are required in comparing anticoagulants, antiplatelets to placebo in solid organ transplantati...
Source: Cochrane Database of Systematic Reviews - March 15, 2021 Category: General Medicine Authors: Vignesh Surianarayanan Thomas J Hoather Samuel J Tingle Emily R Thompson John Hanley Colin H Wilson Source Type: research