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Molecules, Vol. 27, Pages 4285: High Expression Level of & alpha;2-3-Linked Sialic Acids on Salivary Glycoproteins of Breastfeeding Women May Help to Protect Them from Avian Influenza Virus Infection
Molecules, Vol. 27, Pages 4285: High Expression Level of α2-3-Linked Sialic Acids on Salivary Glycoproteins of Breastfeeding Women May Help to Protect Them from Avian Influenza Virus Infection Molecules doi: 10.3390/molecules27134285 Authors: Li Ding Yimin Cheng Wei Guo Siyue Sun Xiangqin Chen Tiantian Zhang Hongwei Cheng Jiayue Hao Yunhua Lu Xiurong Wang Zheng Li Terminal sialic acids (Sia) on soluble glycoprotein of saliva play an important role in the clearance of influenza virus. The aim of this study is to investigate the alteration of sialylation on the salivary proteins of women...
Source: Molecules - July 3, 2022 Category: Chemistry Authors: Li Ding Yimin Cheng Wei Guo Siyue Sun Xiangqin Chen Tiantian Zhang Hongwei Cheng Jiayue Hao Yunhua Lu Xiurong Wang Zheng Li Tags: Article Source Type: research

Hepatic and neurobiological effects of foetal and breastfeeding and adulthood exposure to methylmercury in Wistar rats.
Abstract Methylmercury (MeHg) is an organic bioaccumulated mercury derivative that strongly affects the environment and represents a public health problem primarily to riparian communities in South America. Our objective was to investigate the hepatic and neurological effects of MeHg exposure during the phases foetal and breast-feeding and adult in Wistar rats. Wistar rats (n = 10) were divided into 3 groups. Control group received mineral oil; The simple exposure (SE) group was exposed only in adulthood (0.5 mg/kg/day); and double exposure (DE) was pre-exposed to MeHg 0.5 mg/kg/day during pregnancy and breast...
Source: Chemosphere - March 13, 2020 Category: Chemistry Authors: Rosa-Silva HTD, Panzenhagen AC, Schmidtt V, Alves Teixeira A, Espitia-Pérez P, de Oliveira Franco Á, Mingori M, Torres-Ávila JF, Schnorr CE, Hermann PRS, Moraes DP, Almeida RF, Moreira JCF Tags: Chemosphere Source Type: research

INFERYS Rescoring: boosting peptide identifications and scoring confidence of database search results
Rapid Commun Mass Spectrom. 2021 May 20:e9128. doi: 10.1002/rcm.9128. Online ahead of print.ABSTRACTDatabase search engines for bottom-up proteomics largely ignore peptide fragment ion intensities during the automated scoring of tandem mass spectra against protein databases. Recent advances in deep learning allow the accurate prediction of peptide fragment ion intensities. Using these predictions to calculate additional intensity-based scores help to overcome this drawback. Here, we describe a processing workflow termed INFERYS™ Rescoring for the intensity-based rescoring of Sequest HT search engine results in Thermo Sci...
Source: Rapid Communications in Mass Spectrometry : RCM - May 20, 2021 Category: Chemistry Authors: Daniel P Zolg Siegfried Gessulat Carmen Paschke Michael Graber Magnus Rathke-Kuhnert Florian Seefried Kai Fitzemeier Frank Berg Daniel Lopez-Ferrer David Horn Christoph Henrich Andreas Huhmer Bernard Delanghe Martin Frejno Source Type: research

Understanding the Target Search by Multiple Transcription Factors on Nucleosomal DNA
In this study, by developing a theoretical model based on a discrete-state stochastic approach, we investigated the target search mechanism of multiple TFs on nucleosomal DNA. Experimental kinetic rate constants of different TFs are taken as input to estimate the Mean-First-Passage time to recognize the binding motifs by two TFs on a dynamic nucleosome model. The theory systematically analyzes when the TFs search their binding motifs hierarchically and when simultaneously by proceeding via the formation of a protein-protein complex. Our results, validated by extensive Monte Carlo simulations, elucidate the molecular basis ...
Source: Chemphyschem - January 5, 2023 Category: Chemistry Authors: Sujeet Kumar Mishra Arnab Bhattacherjee Source Type: research

Effects on pregnancy and breastfeeding on DDT residues warrant further attention.
PMID: 24953523 [PubMed - as supplied by publisher]
Source: Chemosphere - June 19, 2014 Category: Chemistry Authors: Manaca MN, Grimalt JO, Sunyer J, Mandomando I, Gonzalez R, Sacarlal J, Dobaño C, Alonso PL, Menendez C Tags: Chemosphere Source Type: research

Vitamin D, Breastfeeding and Food Allergy.
Abstract In as much as many infants develop allergic symptoms early in infancy, and exposure to allergens may be important in the development of food allergies, there is great interest in maternal dietary strategies during pregnancy and lactation that may prevent food allergies, and thus reduce the burden of disease. Vitamin D levels are known to be associated with atopic disease development in early infancy; however, existing data are controversial. The aim of this review was to investigate any possible effect of vitamin D on the onset of neonatal allergy via breast feeding. PMID: 26242702 [PubMed - in process]
Source: Mini Reviews in Medicinal Chemistry - August 9, 2015 Category: Chemistry Authors: Tsabouri S, Challa A, Giapros V, Chaliasos N Tags: Mini Rev Med Chem Source Type: research

Evidential significance of automotive paint trace evidence using a pattern recognition based infrared library search engine for the Paint Data Query Forensic Database.
Abstract A prototype library search engine has been further developed to search the infrared spectral libraries of the paint data query database to identify the line and model of a vehicle from the clear coat, surfacer-primer, and e-coat layers of an intact paint chip. For this study, search prefilters were developed from 1181 automotive paint systems spanning 3 manufacturers: General Motors, Chrysler, and Ford. The best match between each unknown and the spectra in the hit list generated by the search prefilters was identified using a cross-correlation library search algorithm that performed both a forward and ba...
Source: Talanta - July 31, 2016 Category: Chemistry Authors: Lavine BK, White CG, Allen MD, Fasasi A, Weakley A Tags: Talanta Source Type: research

A technical review of three clinical trials register resources indicates where improvements to the search interfaces are needed
This article is protected by copyright. All rights reserved.
Source: Research Synthesis Methods - February 11, 2021 Category: Chemistry Authors: Chris Cooper, Rachel Court, Eleanor Kotas, Ute Schauberger Tags: RESEARCH ARTICLE Source Type: research