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Total 89143 results found since Jan 2013.

Breastfeeding After Organ Transplantation
Breastfeeding Medicine, Ahead of Print.
Source: Breastfeeding Medicine - December 18, 2019 Category: Perinatology & Neonatology Authors: Philip O. Anderson Source Type: research

Human Milk to Prevent and Heal Gastrointestinal Tract Injury in Children After Bone Marrow Transplantation
Breastfeeding Medicine,Volume 13, Issue S1, Page S-18-S-19, April 2018.
Source: Breastfeeding Medicine - April 1, 2018 Category: Perinatology & Neonatology Authors: Stella M. Davies Source Type: research

Potential Immunomodulatory Benefits of Human Milk in the Management of Transplants
Breastfeeding Medicine, Ahead of Print.
Source: Breastfeeding Medicine - February 20, 2019 Category: Perinatology & Neonatology Authors: Arthur I. Eidelman Source Type: research

A Pilot Study of Human Milk to Reduce Intestinal Inflammation After Bone Marrow Transplant
Breastfeeding Medicine, Ahead of Print.
Source: Breastfeeding Medicine - March 26, 2019 Category: Perinatology & Neonatology Authors: Pooja Khandelwal Heidi Andersen Lindsey Romick-Rosendale Cynthia B. Taggart Miki Watanabe Adam Lane Christopher E. Dandoy Kelly E. Lake Bridget A. Litts Ardythe L. Morrow Martin L. Lee David B. Haslam Stella M. Davies Source Type: research

Is a Matched Unrelated Donor Search Needed for All Allogeneic Transplant Candidates?
ConclusionsRace, haplotype frequency and disease status at the time of MUD search influence probability to identify a MUD and receive a transplant. Patients with low likelihood to receive a MUD transplant may proceed to a haploidentical transplant as soon as indicated, as this approach does not appear to compromise transplant outcomes.DisclosuresKonopleva: Stemline Therapeutics: Research Funding. Oran: AROG pharmaceuticals: Research Funding; Celgene: Consultancy, Research Funding; ASTEX: Research Funding. Champlin: Otsuka: Research Funding; Sanofi: Research Funding.
Source: Blood - November 21, 2018 Category: Hematology Authors: Ciurea, S. O., Borges Bittencourt, M. C., Milton, D. R., Cao, K., Kongtim, P., Rondon, G., Chen, J., Konopleva, M. Y., Ramos Perez, J. M., Elshazly, M., Aljadayeh, M., Alvarez, M., Im, J. S., Alatrash, G., Mehta, R. S., Popat, U., Bashir, Q., Oran, B., Ho Tags: 732. Clinical Allogeneic Transplantation: Results: Poster II Source Type: research

The Rome Transplant Network model compared to the Italian Bone Marrow Donor Registry activity for unrelated donor search process and transplant efficiency for hematologic malignancy.
CONCLUSIONS: Both PQ and HR HLA at the start of the process represents a useful tool to address the search towards the best and timely donor choice. Moreover, establishing a specific donor policy significantly improves the transplant efficiency. PMID: 28608367 [PubMed - as supplied by publisher]
Source: Transfusion - June 13, 2017 Category: Hematology Authors: Picardi A, Arcese W, Pollichieni S, Di Piazza F, Mangione I, Gallina AM, Cerretti R, Cudillo L, De Angelis G, Mengarelli A, Dentamaro T, Tirindelli MC, Chierichini A, Ferrari A, Marciano R, Andreani M, Bonifazi F, Sacchi N Tags: Transfusion Source Type: research

Outcome of patients activating an unrelated donor search for severe acquired aplastic anemia
This study analyzes the outcome of ATG‐refractory SAA patients activating a VUD search. Of 179 patients, 68 had at least one HLA‐A, –B and –DR matched donor identified and underwent HSCT while 50 also with a donor were not transplanted because of early death (8), late response to IST (34), transplant refusal (1) or other (7). Conversely, 61 had no matched donor, 13 of those ultimately received a mismatched HSCT. All but one received marrow stem cells. Among patients aged <17 years, those with at least one matched donor had a significant higher 4‐year survival as compared to others (79%+/‐6% versus 53%+/‐10...
Source: American Journal of Hematology - June 27, 2013 Category: Hematology Authors: Sébastien Maury, Marie‐Lorraine Balère‐Appert, Simona Pollichieni, Rosi Oneto, Ibrahim Yakoub‐Agha, Franco Locatelli, Jean‐Hugues Dalle, Edoardo Lanino, Alain Fischer, Andrea Pession, Anne Huynh, Walter Barberi, Mohamad Mohty, Antonio Risitano, Tags: Research Article Source Type: research

Using Haplogictm & Recipient Ancestry: The Likelihood of Identifying an 8/8 HLA-Matched Unrelated Donor Can be Accurately Predicted at the Time of the Preliminary Search Markedly Improving Search Efficiency & Speed to Allograft: An 830 Patient Analysis
Background: As many searches are urgent, a strategy to rapidly& efficiently establish if a suitable unrelated donor (URD) can be identified is needed. The standard URD HLA-match requirement at our center is 8/8 HLA-A,B,C,DRB1 alleles. The National Marrow Donor Program (NMDP) provides a computerized % chance of 8/8& individual locus HLA-match predictions (HapLogic ™) for URDs on the NMDP search based on available HLA-typing& ancestry of the patient (pt)& URD. We hypothesized that the likelihood of an 8/8 URD could be accurately estimated by devising a Search Prognosis Categorization (SPC) based upon the number of potentia...
Source: Biology of Blood and Marrow Transplantation - February 22, 2017 Category: Hematology Authors: Eric Davis, Sean M. Devlin, Candice Cooper, Melissa Nhaissi, Jennifer Paulson, Deborah S. Wells, Andromachi Scaradavou, Sergio A. Giralt, Esperanza B. Papadopoulos, Nancy A. Kernan, Courtney Byam, Juliet N. Barker Source Type: research

Comparison of Search Prognosis Algorithms Demonstrates the Value of HapLogicTM-Based Assessment in Predicting the Likelihood of Identifying 8/8 HLA-Allele Matched Unrelated Donors (URD) & Receiving an 8/8 URD Transplant
Using preliminary search National Marrow Donor Program (NMDP) HapLogic ™ predictions, we have developed a search prognosis algorithm that accurately predicts the likelihood of patients having an 8/8 HLA-matched URD (Davis et al, BBMT 2018). An alternative approach is to categorize search prognosis by patient HLA genotype frequency& ancestry (Wadsworth et al, BMT 2016). We compared these search prognosis assessment methods.
Source: Biology of Blood and Marrow Transplantation - January 24, 2020 Category: Hematology Authors: Eric Davis, Sean M. Devlin, Candice Cooper, Melissa Nhaissi, Deborah S. Wells, Sergio A. Giralt, Esperanza B. Papadopoulos, Ioannis Politikos, Juliet N. Barker Tags: 451 Source Type: research

Influence of the HLA characteristics of Italian patients on donor search outcome in unrelated hematopoietic stem cell transplantation
In this study, we retrospectively analyzed 315 Italian patients who started a search for a MUD, in order to assess the distribution of human leukocyte antigen (HLA) alleles and haplotypes in this population of patients and to evaluate the probability of finding a donor. Comparing two groups of patients based on whether or not a 10/10 HLA‐matched donor was available, we found that patients who had a fully‐matched MUD possessed at least one frequent haplotype more often than the others (45.6% vs 14.3%; P = 0.000003). In addition, analysis of data pertaining to the HLA class I alleles distribution showed that, in the ...
Source: Tissue Antigens - April 18, 2014 Category: Allergy & Immunology Authors: M. Testi, M. Andreani, F. Locatelli, W. Arcese, M. Troiano, M. Battarra, J. Gaziev, G. Lucarelli Tags: Original article Source Type: research

High-performance information search filters for acute kidney injury content in PubMed, Ovid Medline and Embase
Conclusions PubMed, Ovid Medline and Embase can be filtered for articles relevant to AKI in a reliable manner. These high-performance information filters are now available online and can be used to better identify AKI content in large bibliographic databases.
Source: Nephrology Dialysis Transplantation - March 27, 2014 Category: Urology & Nephrology Authors: Hildebrand, A. M., Iansavichus, A. V., Haynes, R. B., Wilczynski, N. L., Mehta, R. L., Parikh, C. R., Garg, A. X. Tags: Acute Kidney Injury Source Type: research

A novel tool for the identification of correlations in medical data by faceted search
We describe the details of the use case of transplant medicine and the resulting technical architecture of the faceted search application.
Source: Computers in Biology and Medicine - April 14, 2017 Category: Bioinformatics Authors: Danilo Schmidt, Oliver Staeck, Klemens Budde, Daniel Sonntag, Hans-J ürgen Profitlich, Matthias Ihle Source Type: research

Validation of an Algorithm to Predict the Likelihood of an 8/8 HLA-Matched Unrelated Donor at Search Initiation
• HapLogic™ provides reliable 8/8 and individual locus HLA-match predictions for unrelated donors (URDs).• A novel Search Prognosis patient categorization can accurately predict 8/8 HLA-matched URD likelihood at search initiation.• Rapid recognition of poor, very poor or futile searches can facilitate immediate pursuit of alternative graft sources.
Source: Biology of Blood and Marrow Transplantation - December 26, 2017 Category: Hematology Authors: Eric Davis, Sean Devlin, Candice Cooper, Melissa Nhaissi, Jennifer Paulson, Deborah Wells, Andromachi Scaradavou, Sergio Giralt, Esperanza Papadopoulos, Nancy A. Kernan, Courtney Byam, Juliet N. Barker Source Type: research

Outcomes of strategic alternative donor selection or suspending donor search based on Japan Marrow Donor Program coordination status.
Abstract In allogeneic hematopoietic stem cell transplantation (allo-HSCT) from unrelated donors, delays in donor search are adversely associated with patient outcome. However, the optimal duration for either waiting for an unrelated donor or selecting alternative sources remains undetermined. Using data from the Japan Marrow Donor Program (JMDP) registry, we retrospectively analyzed 349 adult patients who had searched for unrelated donors. Two hundred and three patients received allo-HSCT from JMDP donors (Group A) with a median of 140 days required to identify a donor, 60 received allo-HSCT from alternative sou...
Source: International Journal of Hematology - January 27, 2018 Category: Hematology Authors: Kawashima N, Nishiwaki S, Shimizu N, Kamoshita S, Watakabe K, Yokohata E, Kurahashi S, Ozawa Y, Miyamura K Tags: Int J Hematol Source Type: research

Improved accuracy of clinical HLA genotyping by next-generation DNA sequencing affects unrelated donor search results for hematopoietic stem cell transplantation.
Abstract Matching of human leukocyte antigen (HLA) genes is critically important in hematopoietic stem cell transplantation (HSCT). HLA genes are highly polymorphic and HLA matching has historically been limited by technologies that are unable to unambiguously determine HLA genotypes. Next generation DNA sequencing (NGS) overcomes these limitations by enabling near full-gene sequences with phase determination for heterozygous alleles. Here we examine the efficacy and utility of HLA-NGS in the clinical setting. In a 54-sample validation study and 955 patient samples subsequently tested using HLA-NGS, we observed si...
Source: Human Immunology - October 11, 2018 Category: Allergy & Immunology Authors: Allen ES, Yang B, Garrett J, Ball ED, Maiers M, Morris GP Tags: Hum Immunol Source Type: research