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Drug: Penicillin

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Total 1616 results found since Jan 2013.

Penicillin Allergy
Allergy to penicillin can occur via any of the 4 types of Gel-Coombs hypersensitivity reactions, producing distinct clinical histories and physical examination findings. Treatments include penicillin discontinuation, and depending on the type of reaction, epinephrine, antihistamines, and/or glucocorticoids. Most beta-lactams may be safely used in penicillin-allergic patients, with the possible exception of first-generation and second-generation cephalosporins. Penicillin testing includes skin testing, patch testing, and graded challenge. The selection of the type of testing depends on the clinical setting, equipment availa...
Source: Primary Care: Clinics in Office Practice - February 26, 2023 Category: Primary Care Authors: Estelle A. Green, Kelan Fogarty, Faoud T. Ishmael Source Type: research

Study protocol for PREPARE: a phase II feasibility/safety randomised controlled trial on PeRiopErative Penicillin AlleRgy TEsting
Introduction Patient-reported antibiotic allergy labels (AALs) are common. These labels have been demonstrated to have a negative impact on use of appropriate antibiotics and patient-related health outcomes. These patients are more likely to receive suboptimal antibiotics, have increased rates of surgical site infections and are more likely to be colonised with multidrug-resistant organisms. Increasing recognition that antibiotic allergy forms a key part of good antimicrobial stewardship has led to calls for greater access to antibiotic allergy assessment. PREPARE is a pilot randomised controlled trial of beta-lactam aller...
Source: BMJ Open - February 24, 2023 Category: General Medicine Authors: De Luca, J. F., James, F., Vogrin, S., Chua, K., Fletcher, L., Nazareth, J., Guha, R., Hardidge, A., Douglas, N., Carruthers, J., Stewardson, A., Cheng, A. C., Johnson, D., Douglass, J., Peel, T., Trubiano, J. Tags: Open access, Immunology (including allergy) Source Type: research

Deconstructing adverse reactions to Amoxicillin-Clavulanic Acid: the importance of time of onset
CONCLUSION: Allergy diagnosis was confirmed in a minority of the whole study population, but 5 times more frequently in those reporting immediate reactions, making this classification useful in risk stratification. Late-positive IDT for CL has no diagnostic value and its late reading could be retrieved from the diagnosis work-up.PMID:36811840 | DOI:10.18176/jiaci.0896
Source: Journal of Investigational Allergology and Clinical Immunology - February 22, 2023 Category: Allergy & Immunology Authors: N P Freundt-Serpa M Salas-Cassinello A Gonzalo-Fern ández N March án-Pinedo I Do ña I Serrano-Garc ía A M Humanes-Navarro G Bogas M Labella L S ánchez-Morillas M J Torres M Fern ández-Rivas Source Type: research

Self-reported beta-lactam allergy in government and private hospitals in Cape Town, South Africa
CONCLUSION: Unlike HICs, self-reported BLA is low among inpatients in SA. The majority of those who self-reported BLA were low risk fortype 1 hypersensitivity, but outpatient de-labelling efforts were largely unsuccessful.PMID:36757070 | DOI:10.7196/SAMJ.2023.v113i2.16760
Source: South African Medical Journal - February 9, 2023 Category: African Health Authors: C Day M Deetlefs A O'Brien J Smith M Boyd N Embling S Patel K Moody T Ramabele A Budge T Tarwa O Jim T Maharaj S Pandy J-M Abrahams A Panieri S Verhage M Van der Merwe A Geragotellis W Amanjee C Joseph Z Zhao S Moosa M Bunting Y Pulani P Mukhari M De Paiv Source Type: research