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Drug: Penicillin

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Total 1616 results found since Jan 2013.

Association between chronic urticaria and self-reported penicillin allergy.
CONCLUSION: This link between chronic urticaria and self-reported penicillin allergy highlights the need for clinicians to inquire about self-reported penicillin allergy in patients with chronic urticaria and to consider penicillin skin testing. Furthermore, patients who report penicillin allergy might actually have chronic urticaria, indicating the importance of inquiring about chronic urticaria symptoms in patients with self-reported penicillin allergy. PMID: 26782670 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 9, 2016 Category: Allergy & Immunology Authors: Silverman S, Localio R, Apter AJ Tags: Ann Allergy Asthma Immunol Source Type: research

Allergy test outcomes in patients self-reported as having penicillin allergy: Two-year experience.
CONCLUSION: Only 28.6% of patients with self-reported penicillin allergy were confirmed to be allergic. Importantly, when the index drug is amoxicillin-clavulanic acid or flucloxacillin, the patients may tolerate amoxicillin. PMID: 27613461 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - August 31, 2016 Category: Allergy & Immunology Authors: Meng J, Thursfield D, Lukawska JJ Tags: Ann Allergy Asthma Immunol Source Type: research

Pre-Operative Penicillin Allergy Testing in Cardiac Surgery Patients.
CONCLUSION: Integrating penicillin allergy evaluation into routine pre-operative care ensured that almost all cardiac surgery patients evaluated received first-line antibiotic prophylaxis, a critical component of SSI risk reduction. Further efforts are needed to increase access to pre-operative allergy evaluation. PMID: 32217188 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 22, 2020 Category: Allergy & Immunology Authors: Plager JH, Mancini CM, Fu X, Melnitchouk S, Shenoy ES, Banerji A, Collier L, Chaudhary N, Yerneni S, Zhang Y, Blumenthal KG Tags: Ann Allergy Asthma Immunol Source Type: research

Children with reported penicillin allergy: Public health impact and safety of delabeling.
CONCLUSION: Penicillin allergy is overdiagnosed, often incorrectly, and the label is frequently first applied during childhood. Targeting children for the removal of the incorrect penicillin allergy label provides a mechanism to reduce the use of broader-spectrum and less effective antibiotics. PMID: 32224207 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 25, 2020 Category: Allergy & Immunology Authors: Vyles D, Antoon JW, Norton A, Stone CA, Trubiano J, Radowicz A, Phillips EJ Tags: Ann Allergy Asthma Immunol Source Type: research

Piperacillin-Tazobactam Allergies: An Exception to Usual Penicillin Allergy.
CONCLUSIONS: There is growing utilization of PT and corresponding cases of suspected allergies. The majority of suspected PT allergies had increased risk for recurrent infections. Unlike other penicillin allergy, there is a high rate of genuine PT allergy (up to 30%) and a poor NPV of ST (up to 70%). DPT remains the gold standard for accurate diagnosis, and all patients with a suspected allergy should undergo thorough allergy workup. PMID: 33474862 [PubMed]
Source: Allergy, Asthma and Immunology Research - January 23, 2021 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Intrapartum antibiotic exposure for group B Streptococcus treatment did not increase penicillin allergy in children.
CONCLUSION: To the authors' knowledge, this is the first study to evaluate intrapartum exposure to penicillin for GBS treatment and subsequent development of penicillin allergy in the child. In contrast to other atopic diseases, intrapartum antibiotic exposure does not alter the risk of penicillin allergy. Parents and obstetricians should be reassured when using penicillin for prevention of neonatal GBS. PMID: 26815706 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 28, 2016 Category: Allergy & Immunology Authors: May SM, Hartz MF, Joshi AY, Park MA Tags: Ann Allergy Asthma Immunol Source Type: research

A survey of inpatient practitioner knowledge of penicillin allergy at 2 community teaching hospitals.
CONCLUSION: There is an overall limited understanding of the management of patients with a history of penicillin allergy in the hospital setting, where collaborative efforts between allergy and nonallergy health care practitioners are sparse. The expansion of a multidisciplinary approach may optimize antimicrobial prescribing in this subset of patients. PMID: 28539186 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 20, 2017 Category: Allergy & Immunology Authors: Staicu ML, Soni D, Conn KM, Ramsey A Tags: Ann Allergy Asthma Immunol Source Type: research

Prospective assessment of diagnostic tests for pediatric penicillin allergy, from clinical history to challenge tests ✰,✰✰,✰✰✰.
CONCLUSION: Conventional predictors of allergy to penicillin performed weakly. The authors propose straightforward penicillin provocation testing in controlled, experienced centers for the diagnosis of non-severe penicillin allergy in children. PMID: 29803713 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 24, 2018 Category: Allergy & Immunology Authors: Ibáñez MD, Del Río PR, Lasa EM, Joral A, Ruiz-Hornillos J, Muñoz C, Traseira CG, Escudero C, Olaguibel Rivera JM, Garriga-Baraut T, González-de-Olano D, Rosado A, Sanchez-García S, Bustamante SP, Vilchez MAP, Montaño PP, Morillo RC, Iglesia EM, Vil Tags: Ann Allergy Asthma Immunol Source Type: research

Inpatient Beta-lactam test-dose Protocol promotes Antimicrobial Stewardship in Patients with History of Penicillin Allergy.
CONCLUSION: The antibiotic choice in patients admitted to the hospital with a reported penicillin allergy can be improved by better evaluation of the allergy history and the use of a risk stratification guideline. PMID: 30465860 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - November 19, 2018 Category: Allergy & Immunology Authors: Sacco KA, Cochran BP, Epps K, Parkulo M, Gonzalez-Estrada A Tags: Ann Allergy Asthma Immunol Source Type: research

Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy.
CONCLUSION: The implementation of an inpatient antibiotic prescribing guideline for patients with penicillin or cephalosporin allergy was associated with an almost 7-fold increase in the number of test doses to β-lactams without increased adverse drug reactions. Patients assessed with guideline-driven test doses were observed to have significantly decreased alternative antibiotic exposure. PMID: 26070805 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - June 9, 2015 Category: Allergy & Immunology Authors: Blumenthal KG, Shenoy ES, Varughese CA, Hurwitz S, Hooper DC, Banerji A Tags: Ann Allergy Asthma Immunol Source Type: research

Skin testing only with penicillin G in children with a history of penicillin allergy.
CONCLUSION: Among children with a history of penicillin allergy, skin testing only with penicillin G followed by a 3-dose graded challenge to the incriminated penicillin is safe and yields a good NPV. This approach could be useful when PPL is unavailable. PMID: 24856884 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 22, 2014 Category: Allergy & Immunology Authors: Picard M, Paradis L, Bégin P, Paradis J, Des Roches A Tags: Ann Allergy Asthma Immunol Source Type: research

Penicillin allergy: optimizing diagnostic protocols, public health implications, and future research needs
Purpose of review: Unverified penicillin allergy is being increasingly recognized as a public health concern. The ideal protocol for verifying true clinically significant IgE-mediated penicillin allergy needs to use only commercially available materials, be well tolerated and easy to perform in both the inpatient and outpatient settings, and minimize false-positive determinations. This review concentrates on articles published in 2013 and 2014 that present new data relating to the diagnosis and management of penicillin allergy. Recent findings: Penicillin allergy can be safely evaluated at this time, in patients with an ap...
Source: Current Opinion in Allergy and Clinical Immunology - June 26, 2015 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Bernard Y.-H. Thong Source Type: research

Systematic review of professional liability when prescribing beta-lactams for patients with a known penicillin allergy.
CONCLUSION: The cases with published legal outcomes found limited professional liability for clinicians who prescribed either cephalosporins or carbapenems to a patient with a known penicillin allergy. These results may decrease the litigation fears of providers and risk managers within healthcare systems. PMID: 29551402 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - March 15, 2018 Category: Allergy & Immunology Authors: Jeffres MN, Hall-Lipsy EA, King ST, Cleary JD Tags: Ann Allergy Asthma Immunol Source Type: research

Drug allergy is associated with the development of extraintestinal manifestations in patients with ulcerative colitis.
Authors: Toledo-Maurino JJ Abstract Summary: Drug allergies are developed by antibody or cell-mediated reactions as immunologic mechanisms. It has been demonstrated that hypersensitivity reaction to certain allergens may play a role in the pathogenesis of inflammatory bowel disease (IBD) focused on food allergies. A total of 256 patients with UC were divided in two groups: 203 patients with active UC and 53 in remission UC were included in the present study. In the present study we found that 11.7% had allergy to at least one drug distributed. The most frequent drug-allergies were sulfonamides in 2.8% and penicilli...
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Achieving The Quadruple Aim To Deliver Value-Based Allergy Care In An Ever-Evolving Healthcare System.
CONCLUSION: As healthcare systems continue to evolve, allergists and immunologists will play a key role in optimizing value by translating emerging evidence into practice and communicating novel approaches to prevent and treat allergic diseases. PMID: 32289524 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - April 10, 2020 Category: Allergy & Immunology Authors: Iglesia EGA, Greenhawt M, Shaker MS Tags: Ann Allergy Asthma Immunol Source Type: research