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Updated Imaging Findings in Congenital Zika Syndrome: A Disease Story That is Still Being Written
In congenital Zika virus syndrome (CZS), the most frequent radiological findings are calcifications in the cortical–white matter junction and malformations of cortical development (pachygyria or polymicrogyria, which occur predominantly in the frontal lobes, or a simplified gyral pattern), ventriculomegaly, enlargement of the cisterna magna and the extra-axial subarachnoid space, corpus callosum abnormalities, and reduced brain volume. This syndrome can also result in a decrease in the brainstem and cerebellum volumes and delayed myelination. Infants with CZS may show venous thrombosis and lenticulostriate vasculopathies...
Source: Topics in Magnetic Resonance Imaging - February 1, 2019 Category: Radiology Tags: Review Articles Source Type: research

Nonmicrocephalic Infants with Congenital Zika Syndrome Suspected Only after Neuroimaging Evaluation Compared with Those with Microcephaly at Birth and Postnatally: How Large Is the Zika Virus "Iceberg"? PEDIATRICS
CONCLUSIONS: In microcephaly at birth, except for polymicrogyria, all patients showed abnormalities described in the literature. In postnatal microcephaly, the only abnormalities not seen were a simplified gyral pattern and calcifications outside the cortico-subcortical junction. Infants with normocephaly presented with asymmetric frontal polymicrogyria, calcifications in the cortico-subcortical junction, mild ventriculomegaly, and delayed myelination.
Source: American Journal of Neuroradiology - July 12, 2017 Category: Radiology Authors: Aragao, M. F. V. V., Holanda, A. C., Brainer-Lima, A. M., Petribu, N. C. L., Castillo, M., van der Linden, V., Serpa, S. C., Tenorio, A. G., Travassos, P. T. C., Cordeiro, M. T., Sarteschi, C., Valenca, M. M., Costello, A. Tags: PEDIATRICS Source Type: research

Serial Head and Brain Imaging of 17 Fetuses With Confirmed Zika Virus Infection in Colombia, South America.
CONCLUSION: Our analysis suggests a period of at least 15 weeks between maternal Zika virus infection in pregnancy and development of microcephaly and highlights the importance of serial and detailed neuroimaging. PMID: 28594771 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - June 6, 2017 Category: OBGYN Authors: Parra-Saavedra M, Reefhuis J, Piraquive JP, Gilboa SM, Badell ML, Moore CA, Mercado M, Valencia D, Jamieson DJ, Beltran M, Sanz-Cortes M, Rivera-Casas AM, Yepez M, Parra G, Ospina Martinez M, Honein MA Tags: Obstet Gynecol Source Type: research

Spectrum of Spinal Cord, Spinal Root, and Brain MRI Abnormalities in Congenital Zika Syndrome with and without Arthrogryposis PEDIATRICS
CONCLUSIONS: Most infants had some degree of spinal cord thickness reduction, predominant in the thoracic segment (without arthrogryposis) or in the entire spinal cord (with arthrogryposis). The conus medullaris anterior roots were reduced in both groups (thinner in arthrogryposis). A prominent anterior median fissure of the spinal cord was absent in infants without arthrogryposis. Brain stem hypoplasia was present in all infants with arthrogryposis, periventricular calcifications, in the majority, and polymicrogyria was absent.
Source: American Journal of Neuroradiology - May 15, 2017 Category: Radiology Authors: Aragao, M. F. V. V., Brainer-Lima, A. M., Holanda, A. C., van der Linden, V., Vasco Aragao, L., Silva Junior, M. L. M., Sarteschi, C., Petribu, N. C. L., Valenca, M. M. Tags: PEDIATRICS Source Type: research

Neuroimaging findings of congenital Zika virus infection: a pictorial essay
AbstractZika virus (ZIKV) is a mosquito-borne arbovirus from the Flaviviridae family. It had caused several epidemics since its discovery in 1947, but there was no significant attention to this virus until the recent outbreak in Brazil in 2015. The main concern is the causal relationship between prenatal ZIKV infection and congenital microcephaly, which has been confirmed recently. Moreover, ZIKV may cause other central nervous system abnormalities such as brain parenchymal atrophy with secondary ventriculomegaly, intracranial calcification, malformations of cortical development (such as polymicrogyria, and lissencephaly-p...
Source: Japanese Journal of Radiology - January 9, 2017 Category: Radiology Source Type: research

Prenatal brain MRI of fetuses with Zika virus infection
Conclusion Severe cerebral damage was observed in our series, with indirect findings suggesting that the germinal matrix is the principal target for Zika virus. The lesions are very similar to severe forms of congenital cytomegalovirus and lymphocytic choriomeningitis virus infections.
Source: Pediatric Radiology - April 17, 2016 Category: Radiology Source Type: research