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Clinician Response to Pharmacogenetic Clinical Decision Support Alerts
The objective of this study was to characterize clinician response following standardization of pharmacogenetic (PGx) clinical decision support alerts at University of Florida (UF) Health. A retrospective analysis of all PGx alerts that fired at a tertiary academic medical center from August 2020 through May 2022 was performed. Alert acceptance rate was calculated and compared across six gene-drug pairs, patient care setting, and clinician specialty. The disposition of the triggering medication was compared to the alert response and evaluated for congruence. There were a total of 818 alerts included for analysis of alert r...
Source: Clinical Pharmacology and Therapeutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Lauren K Lemke Emily J Cicali Roy Williams Khoa A Nguyen Larisa H Cavallari Kristin Wiisanen Source Type: research
Artificial Intelligence for Quantitative Modeling in Drug Discovery and Development: An Innovation & amp; Quality (IQ) Consortium Perspective on Use Cases and Best Practices
Clin Pharmacol Ther. 2023 Sep 16. doi: 10.1002/cpt.3053. Online ahead of print.ABSTRACTRecent breakthroughs in Artificial Intelligence (AI) and Machine Learning (ML) have ushered in a new era of possibilities across various scientific domains. One area where these advancements hold significant promise is model-informed drug discovery and development (MID3). To foster a wider adoption and acceptance of these advanced algorithms, the Innovation & Quality (IQ) Consortium initiated the AI/ML working group (WG) in 2021 with the aim of promoting their acceptance among the broader scientific community as well as by regulatory...
Source: Clinical Pharmacology and Therapeutics - September 16, 2023 Category: Drugs & Pharmacology Authors: Nadia Terranova Didier Renard Mohamed H Shahin Sujatha Menon Youfang Cao Cornelis E C A Hop Sean Hayes Kumpal Madrasi Sven Stodtmann Thomas Tensfeldt Pavan Vaddady Nicholas Ellinwood James Lu Source Type: research
Championing the Mom: The Role of a Mother's Support Group in Academic Anesthesia Practice
Anesth Analg. 2023 Oct 1;137(4):777-781. doi: 10.1213/ANE.0000000000006575. Epub 2023 Sep 5.NO ABSTRACTPMID:37712469 | DOI:10.1213/ANE.0000000000006575
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Kinza A Berical Talia S Vogel Jill M Robinson Anna M Ward Jeanine Wiener-Kronish Source Type: research
Assuring the Groundwork for Success: Mentorship, Sponsorship, and Allyship for Practicing Anesthesiologists
Anesth Analg. 2023 Oct 1;137(4):754-762. doi: 10.1213/ANE.0000000000006646. Epub 2023 Sep 5.ABSTRACTThe challenges facing the health care industry in the post-coronavirus disease 2019 (COVID-19) pandemic world are numerous, jeopardizing wellness, and performance. Maintaining engagement and fulfillment of anesthesiologists in their work is now a critical issue in various practice settings: academic, private practice, and corporate medicine. In this article, we offer insights on how mentorship, sponsorship, and allyship are important in the advancement of the anesthesiology workforce including women and underrepresented mino...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Mofya S Diallo Crystal C Wright Alice A Tolbert Coombs Thomas R Vetter Source Type: research
Pro-Con Debate: Consideration of Race, Ethnicity, and Gender Is Detrimental to Successful Mentorship
Anesth Analg. 2023 Oct 1;137(4):747-753. doi: 10.1213/ANE.0000000000006502. Epub 2023 Sep 5.ABSTRACTAnesthesiology remains a specialty with low representation of women or members of racial and ethnic groups considered underrepresented in medicine (UiM). In the United States, women account for 33% of anesthesiology residents, while physicians identifying as Black, African American, Latinx, American Indian, or Alaska Native account for approximately 10%. Underrepresentation of these groups is even more pronounced in academic anesthesiology, especially at the senior ranks and roles, such as department chairs. Leaders in the f...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Alicia B Barclay Kenneth Moran Dmitry Tumin Kimberley R Nichols Source Type: research
The Anesthesiology Physician-Scientist Pipeline: Current Status and Recommendations for Future Growth-An Initiative of the Anesthesia Research Council
Anesth Analg. 2023 Oct 1;137(4):728-742. doi: 10.1213/ANE.0000000000006520. Epub 2023 Sep 5.ABSTRACTThe limited number and diversity of resident physicians pursuing careers as physician-scientists in medicine has been a concern for many decades. The Anesthesia Research Council aimed to address the status of the anesthesiology physician-scientist pipeline, benchmarked against other medical specialties, and to develop strategic recommendations to sustain and expand the number and diversity of anesthesiology physician-scientists. The working group analyzed data from the Association of American Medical Colleges and the Nationa...
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Charles W Emala Vivianne L Tawfik Meghan B Lane-Fall Paloma Toledo Cynthia A Wong Monica S Vavilala Lee A Fleisher Margaret Wood Source Type: research
Effect of work from home and employee mental health through mediating role of workaholism and work-family balance
This study provides real-world guidance to human resource managers on how to prioritize composite-level interventions at all levels of the university to create highly satisfied employees, provide a good working environment, and improve employees' mental health.ORIGINALITY/VALUE: Many researches have been done on the relationship between work-from-home and employee mental health, but relatively few have looked at how work-life balance and workaholism play a role in how work-from-home affects employees' mental health. This study fills a need in the academic and practitioner literature by investigating the relationship betwee...
Source: The International Journal of Social Psychiatry - September 15, 2023 Category: Psychiatry Authors: Chitra Krishnan Shailender Singh Mubashir Majid Baba Source Type: research
Assessment of Sleep Among Lebanese University Medical Trainees During Clinical Years and Association With Shifts, Psychological Stress, and Fatigue
Conclusions: The frequency of significant sleep disturbance among the medical students and residents was found to be high. Academic year, night shifts, stress, fatigue, and hypnotic use were associated with sleep disturbance.Prim Care Companion CNS Disord 2023;25(5):23m03492.Author affiliations are listed at the end of this article.PMID:37713725 | DOI:10.4088/PCC.23m03492
Source: Primary Care - September 15, 2023 Category: Primary Care Authors: Sana Chahine Jad Kassem Samira Wanna Elio Almawy Helene Matar Pascale Salameh Source Type: research
Off-Label Reduced Dose Apixaban in Older Adults With Atrial Fibrillation and Associated Outcomes
CONCLUSION AND RELEVANCE: Older adults with nonvalvular AF are commonly prescribed lower-than-recommended doses of apixaban. However, no significant association was found between empiric off-label reduced dosing and stroke or bleeding outcomes.PMID:37712551 | DOI:10.1177/10600280231199137
Source: The Annals of Pharmacotherapy - September 15, 2023 Category: Drugs & Pharmacology Authors: Ashley M Campbell Elizabeth Pae Eunice Lee Timothy Jacisin Alina Price Jessica DeAngelo Source Type: research
Navigating the Path to Careers in Academic Pharmacy Administration
Am J Pharm Educ. 2023 Sep;87(9):100046. doi: 10.1016/j.ajpe.2022.09.006. Epub 2023 Mar 15.ABSTRACTThe purpose of this commentary is to discuss the qualifications, responsibilities, and keys to success for pharmacy faculty considering a department (or division) chair (head) or dean (including assistant or associate dean) position. The perspectives are those of a department chair, vice dean, and past dean of colleges of pharmacy with extensive experience in pharmacy administration. The qualifications for these administrative positions vary by institution, particularly with respect to the institution's focus on research. Beca...
Source: American Journal of Pharmaceutical Education - September 15, 2023 Category: Universities & Medical Training Authors: Brian L Erstad Sharon L Youmans M Lynn Crismon Source Type: research
Impact of a Neuropsychiatric Therapeutics Course and a Case-Based Course on Pharmacy Students' Mental Health Stigma
CONCLUSION: The decreases in OMS-HC and AQ-9 scores and increases in Recovery and Empowerment scores indicate reductions in mental health stigma. Stigma among students was overall reduced after the therapeutics course and this reduction was maintained after the case-based course.PMID:37714654 | DOI:10.1016/j.ajpe.2023.100125
Source: American Journal of Pharmaceutical Education - September 15, 2023 Category: Universities & Medical Training Authors: Rajkumar J Sevak Celine Chandler May C Lui Adam M Kaye Robert F Halliwell Edward L Rogan Source Type: research
The Challenge of Curricular Overload in the Pharmacy Academy
Am J Pharm Educ. 2023 Sep;87(9):100079. doi: 10.1016/j.ajpe.2023.100079. Epub 2023 May 11.ABSTRACTThe American Association of Colleges of Pharmacy Council of Faculties commissioned a task force during the 2021-2022 academic year to examine the problem of curricular overload. As a result of this task force and the Academy-wide discussions around curricular overload, a consensus has formed around the significance of defining and addressing this challenge. Many institutions have begun work on identifying solutions to curricular overload. This theme issue will identify and describe current solutions to curriculum overload that...
Source: American Journal of Pharmaceutical Education - September 15, 2023 Category: Universities & Medical Training Authors: Katherine A Kelley Victoria L Williams Aleda M H Chen Source Type: research
Qualitative Analysis of Pre- and Post-Promotion/Tenure Review Processes Employed by US Pharmacy Schools
CONCLUSION: This analysis of PT documents revealed that pre/post-tenure reviews were more commonly employed than pre/post-promotion reviews. Documents most frequently described potential negative consequences that may result from unsatisfactory post-promotion/tenure reviews. Academic leaders should consider the implications of these trends within their own institutions and how their own policies may be improved to create clearly articulated, fair, and parallel processes for both tenure-track and non-tenure track faculty.PMID:37714303 | DOI:10.1016/j.ajpe.2023.100590
Source: American Journal of Pharmaceutical Education - September 15, 2023 Category: Universities & Medical Training Authors: Amy M Franks Ben Quattlebaum Nalin Payakachat Source Type: research
The Anesthesiology Physician-Scientist Pipeline: Current Status and Recommendations for Future Growth-An Initiative of the Anesthesia Research Council
Anesth Analg. 2023 Oct 1;137(4):728-742. doi: 10.1213/ANE.0000000000006520. Epub 2023 Sep 5.ABSTRACTThe limited number and diversity of resident physicians pursuing careers as physician-scientists in medicine has been a concern for many decades. The Anesthesia Research Council aimed to address the status of the anesthesiology physician-scientist pipeline, benchmarked against other medical specialties, and to develop strategic recommendations to sustain and expand the number and diversity of anesthesiology physician-scientists. The working group analyzed data from the Association of American Medical Colleges and the Nationa...
Source: Pain Physician - September 15, 2023 Category: Anesthesiology Authors: Charles W Emala Vivianne L Tawfik Meghan B Lane-Fall Paloma Toledo Cynthia A Wong Monica S Vavilala Lee A Fleisher Margaret Wood Source Type: research
Sex-Specific Associations Between Preoperative Hemoglobin and Outcomes After Major Noncardiac Surgery: A Retrospective Cohort Study
CONCLUSIONS: Low preoperative hemoglobin was associated with a higher risk of complications or mortality after elective noncardiac surgery in both men and women. No differences in the strength of associations between sexes were found. Further studies are needed to assess whether these associations are linear or there are sex-specific thresholds of preoperative hemoglobin concentrations below which postoperative risks begin to increase.PMID:37713328 | DOI:10.1213/ANE.0000000000006661
Source: Anesthesia and Analgesia - September 15, 2023 Category: Anesthesiology Authors: Bing-Cheng Zhao Shao-Hui Lei Jia-Ming Liu Shi-Da Qiu Zhi-Wen Yao Jian Liu Fan Deng Zhi-Hao Li Ke-Xuan Liu Source Type: research
