Dissolution Profiles of Immediate Release Products of Various Drugs in Biorelevant Bicarbonate Buffer: Comparison with Compendial Phosphate Buffer
ConclusionsMany IR products showed differences in the dissolution profiles between biorelevant BCB and compendial PPB. With the floating lid method, BCB is as simple and easy to use as PPB. Biorelevant BCB is recommended for dissolution testing. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 23, 2024 Category: Drugs & Pharmacology Source Type: research
Assessment of Tunable Resistive Pulse Sensing (TRPS) Technology for Particle Size Distribution in Vaccine Formulations – A Comparative Study with Dynamic Light Scattering
ConclusionThis analysis shows that TRPS can be used as an orthogonal technique in addition to conventional DLS based methods for more precise and in-depth characterization. Both techniques are efficient in size characterization and produce comparable results, however the choice will depend on the type of formulation and size range to be evaluated. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 22, 2024 Category: Drugs & Pharmacology Source Type: research
Selective Delivery of Clindamycin Using a Combination of Bacterially Sensitive Microparticle and Separable Effervescent Microarray Patch on Bacteria Causing Diabetic Foot Infection
ConclusionThis research offers proof of concept demonstrating the improved dermatokinetic profile of CLY encapsulated in a bacteria sensitive MP form and delivered via MP-CLY-SEMAP. The results of this research can be developed for future research by testing MP-CLY-SEMAPin vivo in appropriate animal models.Graphical Abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 18, 2024 Category: Drugs & Pharmacology Source Type: research
Antimicrobial Activity Classification of Imidazolium Derivatives Predicted by Artificial Neural Networks
ConclusionsThe study concludes that the MLP neural network, along with CART and PCA, is a robust tool for predicting the antimicrobial activity class of imidazolium chlorides against Klebsiella pneumoniae. CART and PCA, used in this study, allowed input variable reduction without significant information loss. High classification accuracy and associated metrics affirm the method ’s potential utility in pre-synthesis assessments, offering valuable insights for antimicrobial compound design. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 17, 2024 Category: Drugs & Pharmacology Source Type: research
Machine Learning Exploration of the Relationship Between Drugs and the Blood –Brain Barrier: Guiding Molecular Modification
ConclusionsThe machine learning models developed can accurately predict BBB permeability, and many drug molecules are likely to have increased BBB penetration if the number of Hydrogen Bond Donors and Acceptors are reduced. These findings suggest that molecular modifications can enhance the efficacy of CNS drugs and provide practical strategies for drug design and development. This is particularly relevant for improving drug penetration of the BBB.Graphical Abstract (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 11, 2024 Category: Drugs & Pharmacology Source Type: research
A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution
ConclusionThe study demonstrated the potential of the radial diffusion-based model to describe dissolution of drug powders. In contrast, the classic Nernst-Brunner equation could under-estimate drug dissolution rate, largely due to the underlying assumption of translational diffusion. Moreover, the study indicated that not all surfaces on a drug particle contribute to dissolution. Therefore, relying on the experimentally-determined specific surface area for predicting drug dissolution is not advisable. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 8, 2024 Category: Drugs & Pharmacology Source Type: research
Combating Alcohol Adduct Impurity in Immunosuppressant Drug Product Manufacturing: A Scientific Investigation for Enhanced Process Control
ConclusionsManufacturing Process II, selectively locates Tacrolimus within the micellar core of HCO-60, this prevent direct contact of ethanol with Tacrolimus which minimizes impurity alcohol adduct formation. This research contributes to the understanding of tacrolimus formulations, offering ways to safeguard product integrity and stability during manufacturing and storage. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Antibiotic Development: Lessons from the Past and Future Opportunities
AbstractThe challenge of antimicrobial resistance is broadly appreciated by the clinical and scientific communities. To assess progress in the development of medical countermeasures to combat bacterial infections, we deployed information gleaned from clinical trials conducted from 2000 to 2021. Whereas private sector interest in cancer grew dramatically over this period, activity to combat bacterial infections remained stagnant. The comparative ambivalence to antimicrobial resistance is reflected in the number of investigative drugs under clinical investigation, their stage of development and most troublingly, a declining ...
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Development and Validation of Matrix of Chemistry, Manufacturing, and Control (MoCMC) System for Intramammary Drug Products (IMM)
ConclusionThis research showed that theMoCMC approach can be used as a tool for intra batch variabilities, genericsversus brand products comparisons, post-approval formulations changes, manufacturing changes, and formulation variabilities. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
Combating Alcohol Adduct Impurity in Immunosuppressant Drug Product Manufacturing: A Scientific Investigation for Enhanced Process Control
ConclusionsManufacturing Process II, selectively locates Tacrolimus within the micellar core of HCO-60, this prevent direct contact of ethanol with Tacrolimus which minimizes impurity alcohol adduct formation. This research contributes to the understanding of tacrolimus formulations, offering ways to safeguard product integrity and stability during manufacturing and storage. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
