Obesity in type 1 diabetes: an overlooked immune-metabolic issue
Expert Rev Endocrinol Metab. 2024 May 6:1-3. doi: 10.1080/17446651.2024.2351868. Online ahead of print.NO ABSTRACTPMID:38709217 | DOI:10.1080/17446651.2024.2351868 (Source: Expert Review of Endocrinology and Metabolism)
Source: Expert Review of Endocrinology and Metabolism - May 6, 2024 Category: Endocrinology Authors: Ernesto Maddaloni Dario Tuccinardi Source Type: research

From islet transplantation to beta-cell regeneration: an update on beta-cell-based therapeutic approaches in type 1 diabetes
Expert Rev Endocrinol Metab. 2024 May 1:1-11. doi: 10.1080/17446651.2024.2347263. Online ahead of print.ABSTRACTINTRODUCTION: Type 1 diabetes (T1D) mellitus is an autoimmune disease in which immune cells, predominantly effector T cells, destroy insulin-secreting beta-cells. Beta-cell destruction led to various consequences ranging from retinopathy and nephropathy to neuropathy. Different strategies have been developed to achieve normoglycemia, including exogenous glucose compensation, whole pancreas transplantation, islet transplantation, and beta-cell replacement.AREAS COVERED: The last two decades of experience have show...
Source: Expert Review of Endocrinology and Metabolism - May 2, 2024 Category: Endocrinology Authors: Asef Azad Hasan Ali Altunbas Ayse Esra Manguoglu Source Type: research

Advancements in the management of obesity: a review of current evidence and emerging therapies
This study aimed to provide a narrative overview of the past, currently available, and future treatment options that offer therapeutic and preventive advantages for obesity management.AREAS COVERED: Historically, rimonabant, and lorcaserin, were approved and used for managing non-syndromic obesity. Currently, orlistat, naltrexone/bupropion, glucagon-like peptide-1 receptor agonist (GLP-1 RA), and a few promising therapeutic agents are under investigation, including retatrutide, cagrilintide and orforglipron, which show promising weight reduction effects. We have developed a search string of the Medical Subject Headings (Me...
Source: Expert Review of Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Mohammed Altigani Abdalla Ahmed Emmanuel Ssemmondo Charlotte Mark-Wagstaff Thozhukat Sathyapalan Source Type: research

Transition from pediatrics to adult health care in girls with turner syndrome
Expert Rev Endocrinol Metab. 2024 Apr 25:1-12. doi: 10.1080/17446651.2024.2347265. Online ahead of print.ABSTRACTINTRODUCTION: Turner Syndrome is a rare condition secondary to a complete or partial loss of one X chromosome, leading to a wide spectrum of clinical manifestations. Short stature, gonadal dysgenesis, cardiovascular malformations, and dysmorphic features characterize its common clinical picture.AREAS COVERED: The main endocrine challenges in adolescent girls with Turner Syndrome are puberty induction (closely intertwined with growth) and fertility preservation. We discuss the most important clinical aspects that...
Source: Expert Review of Endocrinology and Metabolism - April 26, 2024 Category: Endocrinology Authors: Chiara Sabbadin Loris Marin Jacopo Manso Chiara Mozzato Valentina Camozzi Alessandra Andrisani Cinzia Sacchetti Caterina Mian Carla Scaroni Laura Guazzarotti Filippo Ceccato Source Type: research

Methods to predict heart failure in diabetes patients
Expert Rev Endocrinol Metab. 2024 Apr 15:1-16. doi: 10.1080/17446651.2024.2342812. Online ahead of print.ABSTRACTINTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the leading causes of cardiovascular disease and powerful predictor for new-onset heart failure (HF).AREAS COVERED: We focus on the relevant literature covering evidence of risk stratification based on imaging predictors and circulating biomarkers to optimize approaches to preventing HF in DM patients.EXPERT OPINION: Multiple diagnostic algorithms based on echocardiographic parameters of cardiac remodeling including global longitudinal strain/strain rate ar...
Source: Expert Review of Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Alexander E Berezin Tetiana A Berezina Uta C Hoppe Michael Lichtenauer Alexander A Berezin Source Type: research