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Understanding the increasing incidence of neuroendocrine tumors
Expert Rev Endocrinol Metab. 2023 Jul 19:1-9. doi: 10.1080/17446651.2023.2237593. Online ahead of print.ABSTRACTINTRODUCTION: Neuroendocrine tumors (NETs) are a diverse group of tumors with origins from different primary sites such as gastro-entero-pancreatic, lung and endocrine tissue. Worldwide, their incidence has increased in recent decades. Advances in imaging and better clinical awareness are traditionally attributed to this trend; however, other factors such as genetic and environmental contributors are appreciated as well.AREAS COVERED: The purpose of this article is to review the worldwide epidemiologic trends in ...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Surabhi Pathak Jason S Starr Halfdanarson Thorvardur Mohamad Bassam Sonbol Source Type: research

Melatonin modulates tumor metabolism and mitigates metastasis
Expert Rev Endocrinol Metab. 2023 Sep-Nov;18(4):321-336. doi: 10.1080/17446651.2023.2237103. Epub 2023 Jul 19.ABSTRACTINTRODUCTION: Melatonin, originally isolated from the mammalian pineal gland, was subsequently identified in many animal cell types and in plants. While melatonin was discovered to inhibit cancer more than 5 decades ago, its anti-cancer potential has not been fully exploited despite its lack of serious toxicity over a very wide dose range, high safety margin, and its efficacy.AREAS COVERED: This review elucidates the potential mechanisms by which melatonin interferes with tumor growth and metastasis, includ...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Russel J Reiter Ramaswamy Sharma Dun-Xian Tan Gang Huang Luis Gustavo de Almeida Chuffa George Anderson Source Type: research

Understanding the increasing incidence of neuroendocrine tumors
Expert Rev Endocrinol Metab. 2023 Jul 19:1-9. doi: 10.1080/17446651.2023.2237593. Online ahead of print.ABSTRACTINTRODUCTION: Neuroendocrine tumors (NETs) are a diverse group of tumors with origins from different primary sites such as gastro-entero-pancreatic, lung and endocrine tissue. Worldwide, their incidence has increased in recent decades. Advances in imaging and better clinical awareness are traditionally attributed to this trend; however, other factors such as genetic and environmental contributors are appreciated as well.AREAS COVERED: The purpose of this article is to review the worldwide epidemiologic trends in ...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Surabhi Pathak Jason S Starr Halfdanarson Thorvardur Mohamad Bassam Sonbol Source Type: research

Melatonin modulates tumor metabolism and mitigates metastasis
Expert Rev Endocrinol Metab. 2023 Jul 19:1-16. doi: 10.1080/17446651.2023.2237103. Online ahead of print.ABSTRACTINTRODUCTION: Melatonin, originally isolated from the mammalian pineal gland, was subsequently identified in many animal cell types and in plants. While melatonin was discovered to inhibit cancer more than 5 decades ago, its anti-cancer potential has not been fully exploited despite its lack of serious toxicity over a very wide dose range, high safety margin, and its efficacy.AREAS COVERED: This review elucidates the potential mechanisms by which melatonin interferes with tumor growth and metastasis, including i...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Russel J Reiter Ramaswamy Sharma Dun-Xian Tan Gang Huang Luis Gustavo de Almeida Chuffa George Anderson Source Type: research

Understanding the increasing incidence of neuroendocrine tumors
Expert Rev Endocrinol Metab. 2023 Jul 19:1-9. doi: 10.1080/17446651.2023.2237593. Online ahead of print.ABSTRACTINTRODUCTION: Neuroendocrine tumors (NETs) are a diverse group of tumors with origins from different primary sites such as gastro-entero-pancreatic, lung and endocrine tissue. Worldwide, their incidence has increased in recent decades. Advances in imaging and better clinical awareness are traditionally attributed to this trend; however, other factors such as genetic and environmental contributors are appreciated as well.AREAS COVERED: The purpose of this article is to review the worldwide epidemiologic trends in ...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Surabhi Pathak Jason S Starr Halfdanarson Thorvardur Mohamad Bassam Sonbol Source Type: research

Melatonin modulates tumor metabolism and mitigates metastasis
Expert Rev Endocrinol Metab. 2023 Jul 19:1-16. doi: 10.1080/17446651.2023.2237103. Online ahead of print.ABSTRACTINTRODUCTION: Melatonin, originally isolated from the mammalian pineal gland, was subsequently identified in many animal cell types and in plants. While melatonin was discovered to inhibit cancer more than 5 decades ago, its anti-cancer potential has not been fully exploited despite its lack of serious toxicity over a very wide dose range, high safety margin, and its efficacy.AREAS COVERED: This review elucidates the potential mechanisms by which melatonin interferes with tumor growth and metastasis, including i...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Russel J Reiter Ramaswamy Sharma Dun-Xian Tan Gang Huang Luis Gustavo de Almeida Chuffa George Anderson Source Type: research

Understanding the increasing incidence of neuroendocrine tumors
Expert Rev Endocrinol Metab. 2023 Jul 19:1-9. doi: 10.1080/17446651.2023.2237593. Online ahead of print.ABSTRACTINTRODUCTION: Neuroendocrine tumors (NETs) are a diverse group of tumors with origins from different primary sites such as gastro-entero-pancreatic, lung and endocrine tissue. Worldwide, their incidence has increased in recent decades. Advances in imaging and better clinical awareness are traditionally attributed to this trend; however, other factors such as genetic and environmental contributors are appreciated as well.AREAS COVERED: The purpose of this article is to review the worldwide epidemiologic trends in ...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Surabhi Pathak Jason S Starr Halfdanarson Thorvardur Mohamad Bassam Sonbol Source Type: research

Melatonin modulates tumor metabolism and mitigates metastasis
Expert Rev Endocrinol Metab. 2023 Jul 19:1-16. doi: 10.1080/17446651.2023.2237103. Online ahead of print.ABSTRACTINTRODUCTION: Melatonin, originally isolated from the mammalian pineal gland, was subsequently identified in many animal cell types and in plants. While melatonin was discovered to inhibit cancer more than 5 decades ago, its anti-cancer potential has not been fully exploited despite its lack of serious toxicity over a very wide dose range, high safety margin, and its efficacy.AREAS COVERED: This review elucidates the potential mechanisms by which melatonin interferes with tumor growth and metastasis, including i...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Russel J Reiter Ramaswamy Sharma Dun-Xian Tan Gang Huang Luis Gustavo de Almeida Chuffa George Anderson Source Type: research

Understanding the increasing incidence of neuroendocrine tumors
Expert Rev Endocrinol Metab. 2023 Jul 19:1-9. doi: 10.1080/17446651.2023.2237593. Online ahead of print.ABSTRACTINTRODUCTION: Neuroendocrine tumors (NETs) are a diverse group of tumors with origins from different primary sites such as gastro-entero-pancreatic, lung and endocrine tissue. Worldwide, their incidence has increased in recent decades. Advances in imaging and better clinical awareness are traditionally attributed to this trend; however, other factors such as genetic and environmental contributors are appreciated as well.AREAS COVERED: The purpose of this article is to review the worldwide epidemiologic trends in ...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Surabhi Pathak Jason S Starr Halfdanarson Thorvardur Mohamad Bassam Sonbol Source Type: research

Melatonin modulates tumor metabolism and mitigates metastasis
Expert Rev Endocrinol Metab. 2023 Jul 19:1-16. doi: 10.1080/17446651.2023.2237103. Online ahead of print.ABSTRACTINTRODUCTION: Melatonin, originally isolated from the mammalian pineal gland, was subsequently identified in many animal cell types and in plants. While melatonin was discovered to inhibit cancer more than 5 decades ago, its anti-cancer potential has not been fully exploited despite its lack of serious toxicity over a very wide dose range, high safety margin, and its efficacy.AREAS COVERED: This review elucidates the potential mechanisms by which melatonin interferes with tumor growth and metastasis, including i...
Source: Expert Review of Endocrinology and Metabolism - July 19, 2023 Category: Endocrinology Authors: Russel J Reiter Ramaswamy Sharma Dun-Xian Tan Gang Huang Luis Gustavo de Almeida Chuffa George Anderson Source Type: research