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Total 17 results found since Jan 2013.

Policy Implications of the Southern and Central Africa International Center of Excellence for Malaria Research: Ten Years of Malaria Control Impact Assessments in Hypo-, Meso-, and Holoendemic Transmission Zones in Zambia and Zimbabwe
Am J Trop Med Hyg. 2022 Oct 11;107(4_Suppl):68-74. doi: 10.4269/ajtmh.21-1288. Print 2022 Oct 11.ABSTRACTThe International Centers of Excellence for Malaria Research (ICEMR) were established by the National Institute of Allergy and Infectious Diseases more than a decade ago to provide multidisciplinary research support to malaria control programs worldwide, operating in endemic areas and contributing technology, expertise, and ultimately policy guidance for malaria control and elimination. The Southern and Central Africa ICEMR has conducted research across three main sites in Zambia and Zimbabwe that differ in ecology, ent...
Source: Am J Trop Med Hyg - October 13, 2022 Category: Infectious Diseases Authors: Amy Wesolowski Matthew M Ippolito Mary E Gebhardt Ellen Ferriss Jessica L Schue Tamaki Kobayashi Mike Chaponda Jean-Bertin Kabuya Mbanga Muleba Monicah Mburu Japhet Matoba Michael Musonda Ben Katowa Mukuma Lubinda Harry Hamapumbu Limonty Simubali Twig Mud Source Type: research

The Transcriptome of the Salivary Glands of Amblyomma aureolatum Reveals the Antimicrobial Peptide Microplusin as an Important Factor for the Tick Protection Against Rickettsia rickettsii Infection
Conclusion In conclusion, our data show that R. rickettsii exerts a modulatory effect on the transcriptional profile the SG of A. aureolatum. Moreover, RNAi experiments demonstrated that the knockdown of one microplusin increases the susceptibility of ticks to infection, suggesting that this is one important factor for the control of R. rickettsii. The functional characterization of the additional CDSs modulated by infection is warranted and might reveal other factors that interfere with the acquisition and/or transmission of this tick-borne pathogen. Ethics Statement All procedures involving vertebrate animals were car...
Source: Frontiers in Physiology - May 2, 2019 Category: Physiology Source Type: research

Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali
Conclusion Bioinformatics and data science training programs in developing countries necessitate incremental and collaborative strategies for their feasible and sustainable development. The progress described here covered decades of collaborative efforts centered on training and research on computationally intensive topics. These efforts laid the groundwork and platforms conducive for hosting a bioinformatics and data science training program in Mali. Training programs are perhaps best facilitated through Africa’s university systems as they are perhaps best positioned to maintain core resources during lapses in sho...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

Insects and associated arthropods analyzed during medicolegal death investigations in Harris County, Texas, USA: January 2013- April 2016
This study also highlights the importance of potential sources of uncertainty in preparation and interpretation of forensic entomology reports from different scene types.
Source: PLoS One - June 12, 2017 Category: Biomedical Science Authors: Michelle R. Sanford Source Type: research

Dietary shifts have consequences for the repertoire of allergens produced by the European house dust mite
This study aimed to evaluate the effects of mite‐rearing media on allergen production. Mites were adapted to feed on culture media supplemented with proteins, lipids, carbohydrates or beard shavings, and collected to quantify major allergens (Der p 1 and 2) by immunodetection, transcription of allergen genes by real‐time quantitative polymerase chain reaction, and allergen‐related enzymatic activities. All culture media significantly affected the content of major allergens. Modification of macronutrients in the diet produced minor effects on the transcription of allergen genes, but significantly altered mite allergen...
Source: Medical and Veterinary Entomology - April 21, 2017 Category: Veterinary Research Authors: J. C. VIDAL ‐QUIST, F. ORTEGO, S. ROMBAUTS, P. CASTAÑERA, P. HERNÁNDEZ‐CRESPO Tags: Original Article Source Type: research

The influence of household pets on the composition and quantity of allergenic mite fauna within Irish homes: a preliminary investigation
Abstract Allergenic mites are responsible for inducing hypersensitive reactions in genetically predisposed people worldwide. Mites in dust from 30 Irish homes with pets (dogs, n = 23; cats, n = 7) were compared with those in 30 homes without pets. House dust mites constituted 78% of all mites recorded, with Dermatophagoides pteronyssinus (Acariformes: Pyroglyphidae) representing 57–72% of mites in furniture and mattresses in both home types compared with only 22% of mites in pet beds. Although storage mites accounted for just 13% of all mites recorded, they represented 46% of mites recorded in pet beds. Median levels of ...
Source: Medical and Veterinary Entomology - November 17, 2015 Category: Veterinary Research Authors: D. CLARKE, E. DIX, S. LIDDY, M. GORMALLY, M. BYRNE Tags: Original Article Source Type: research

Allergen expression in the European house dust mite Dermatophagoides pteronyssinus throughout development and response to environmental conditions
Abstract House dust mites are a major source of allergy worldwide. While diagnosis and treatment based on mite extracts have remarkably advanced, little information exists on the expression of allergens in mites. We have studied gene expression of eight Dermatophagoides pteronyssinus (Trouessart) (Acari: Pyroglyphidae) allergens (Der p 1, 2, 3, 4, 5, 7, 10 and 21). All allergens showed higher transcription in nymphs compared with larvae or adults, with the only exception of Der p 10. The transcription of Der p 4 and Der p 10, together with the transcription and protein ratios Der p 1 to Der p 2, were higher in males than i...
Source: Medical and Veterinary Entomology - December 1, 2014 Category: Veterinary Research Authors: J. C. VIDAL‐QUIST, F. ORTEGO, M. LOMBARDERO, P. CASTAÑERA, P. HERNÁNDEZ‐CRESPO Tags: Original Article Source Type: research

Mite species identification in the production of allergenic extracts for clinical use and in environmental samples by ribosomal DNA amplification
Abstract. The identification of allergy‐causing mites is conventionally based on morphological characters. However, molecular taxonomy using ribosomal DNA (rDNA) may be particularly useful in the analysis of mite cultures and purified mite fractions in the production of allergenic extracts. Full‐length internal transcribed spacers (ITS1 and ITS2) were obtained from Dermatophagoides farinae, Dermatophagoides pteronyssinus, Dermatophagoides microceras and Euroglyphus maynei (Astigmata: Pyroglyphidae), Glycyphagus domesticus and Lepidoglyphus destructor (Astigmata: Glycyphagidae), Tyrophagus fanetzhangorum, Tyrophagus put...
Source: Medical and Veterinary Entomology - March 1, 2014 Category: Veterinary Research Authors: B. BEROIZ, F. COUSO‐FERRER, F. ORTEGO, M. J. CHAMORRO, C. ARTEAGA, M. LOMBARDERO, P. CASTAÑERA, P. HERNÁNDEZ‐CRESPO Tags: Original Article Source Type: research